, 2013 The family Paramyxoviridae consists of a group of large, enveloped, negative-sense, single-stranded RNA viruses and contains many important human and animal pathogens. Molecular and biochemical characterization over the past decade has revealed an extraordinary breadth of biological diversity among this family of viruses.
Katharine N, Bossart +2 more
openaire +3 more sources
Reengineering paramyxovirus tropism
Virology, 2004 Receptor specificity is a critical determinant of viral tropism, but the capacity of viruses to switch to alternative receptors has not been extensively studied. Here, we engineered the attachment protein of an attenuated measles virus and generated truly retargeted viruses that are blind to the native receptors CD46 and SLAM, but which propagate ...
Hadac, Elizabeth M. +3 more
openaire +2 more sources
Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. [PDF]
, 2017 Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respiratory infections in humans. Two glycoproteins coordinate the infection of host cells, an attachment protein (G), which binds to cell surface receptors, and a fusion (F ...
Jardetzky, Theodore S +9 more
core +2 more sources
Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea)
Viruses, 2019 Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection.
Ian H Mendenhall +7 more
doaj +1 more source
Glycoprotein Interactions in Paramyxovirus Fusion [PDF]
Future Virology, 2009 The Paramyxoviridae are enveloped, negative-stranded RNA viruses, some of which recognize sialic acid-containing receptors, while others recognize specific proteinaceous receptors. The major cytopathic effect of paramyxovirus infection is membrane fusion-induced syncytium formation.
Ronald M, Iorio +2 more
openaire +2 more sources
Cospeciation of coronavirus and paramyxovirus with their bat hosts in the same geographical areas
BMC Ecology and Evolution, 2021 Background Bat-borne viruses are relatively host specific. We hypothesize that this host specificity is due to coevolution of the viruses with their hosts.
Jie Liang, Chunchao Zhu, Libiao Zhang
doaj +1 more source
Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus [PDF]
, 2019 Interferon response suppression by the respiratory syncytial virus relies on two unique nonstructural proteins, NS1 and NS2, that interact with cellular partners through high-order complexes.
Alonso, Leonardo Gabriel +9 more
core +1 more source
Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. [PDF]
PLoS Pathogens, 2016 Paramyxovirus spread generally involves assembly of individual viral particles which then infect target cells. We show that infection of human bronchial airway cells with human metapneumovirus (HMPV), a recently identified paramyxovirus which causes ...
Farah El Najjar +6 more
doaj +1 more source
The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit [PDF]
, 2019 Paramyxoviruses can establish persistent infections both in vitro and in vivo, some of which lead to chronic disease. However, little is known about the molecular events that contribute to the establishment of persistent infections by RNA viruses.
Busse, DC +11 more
core +6 more sources
Paramyxo- and Coronaviruses in Rwandan Bats
Tropical Medicine and Infectious Disease, 2019 A high diversity of corona- and paramyxoviruses have been detected in different bat species at study sites worldwide, including Africa, however no biosurveillance studies from Rwanda have been reported.
Wanda Markotter +9 more
doaj +1 more source