Results 131 to 140 of about 5,226 (177)

Biophysical aspects of cyclodextrin interaction with paraoxon

Magnetic Resonance in Chemistry, 2013
Cyclodextrins are torus‐shaped polymers of glucose that can bind organophosphorous compounds such as nerve agents and pesticides. We demonstrate here that cyclodextrin can bind up to two paraoxon molecules with a Kav of 6775 M‐1. Molecular modeling shows that the paraoxon appears to bind in polar opposite orientation and have an average binding energy ...
Sunil-Datta, Soni, Jayendra B, Bhonsle, Gregory E, Garcia   +2 more
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Paraoxon inhibits GABA uptake in brain synaptosomes

Toxicology in Vitro, 2007
To investigate possible effect of paraoxon (10(-9)-10(-3)M) on GABA uptake, we used rat cerebral cortex synaptosomes. K(m) and V(max) of GABA uptake were determined in presence of paraoxon (10(-3)M). Acetylcholine and its antagonists (atropine and mecamylamine) were used for evaluating cholinergic-dependency of uptake.
Asghar, Ghasemi, Ahmad, Sadidi, Moslem, Mohammadi, Ali, Khoshbaten, Alireza, Asgari   +4 more
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Paraoxon Analogs as Haptens

1973
The use of parathion and other similar insecticides is known to be hazardous to crop-dusters and other personnel exposed to them. Accidental poisoning was, until now, treated by pharmaceutical means only. We have decided to check whether prophylactic protection can be achieved in a completely different manner, i.e., by the use of parathion analogs as ...
R. Corett, A. Kalir, E. Katz, R. Shahar, M. Torten   +4 more
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Toxicokinetics of methyl paraoxon in the dog

Archives of Toxicology, 1987
The toxicokinetics of methyl paraoxon, the active metabolite of the organophosphorus insecticide methyl parathion, were studied in non-anaesthetized dogs after intravenous (2.5 mg/kg) and oral (15 mg/kg) administration of methyl paraoxon. After intravenous administration, distribution and elimination occurred very rapidly and using the data from 5 min ...
E, De Schryver, L, De Reu, F, Belpaire, J, Willems   +3 more
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Paraoxon imprinted biopolymer based QCM sensor

Materials Chemistry and Physics, 2013
Abstract In this study, a novel quartz crystal microbalance (QCM) based on the modification of paraoxon imprinted polymer (TCM-Cd(II)-paraoxon) film onto a quartz crystal sensor has been developed for the determination of paraoxon. The sensor is based on a molecular imprinted polymer (MIP) which can be synthesized using paraoxon as a template ...
Özkütük, Ebru Birlik, Emir Diltemiz, Sibel, Özalp, Elif, Gedikbey, Tevfik, Ersöz, Arzu   +4 more
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The toxicological significance of paraoxon deethylation

Pesticide Biochemistry and Physiology, 1977
Abstract The in vivo formation of deethylation and hydrolytic products of paraoxon degradation after parathion or paraoxon administration was nearly equal in control male rats, and the relative abundance of metabolites was not appreciably altered by pretreatment of rats with enzymeinducing agents.
H.T. Appleton, T. Nakatsugawa
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Paraoxon-induced desensitization and its reversal by tetrodotoxin

General Pharmacology: The Vascular System, 1988
1. Paraoxon (10 microM for 20 min) induced a desensitization of the taenia caecum of the guinea-pig for contractions produced by a number of cholinomimetics. 2. Tetrodotoxin (0.3 microM) reversed the desensitization suggesting involvement of Na+ channels.
A L, Gardner, L K, Choo, F, Mitchelson
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Regional blood flow during paraoxon infusion in rabbits

Archiv f�r Toxikologie, 1982
In anaesthetized and artificially ventilated rabbits an intravenous infusion of paraoxon (0.8 mg/kg) was given over 30 min. The effects on cardiac output, blood flow to various vascular beds, and on the mass discharge of the postganglionic sympathetic efferents to the spleen and kidney were monitored. Immediately following paraoxon infusion atropine (0.
R, Kullmann, J, Reinsberg, M, Amirmanssouri   +2 more
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Organophosphorus pesticide (Paraoxon) analysis using solid state sensors

Sensors and Actuators B: Chemical, 1996
A comparison of two new solid-state biosensors for organophosphorus pesticide analysis is presented, both of which employ the inhibiting action of these toxic compounds versus the enzyme butyrylcholinesterase. The indicating sensor used was a graphite electrode, or a FET, coated with an ion-selective polymeric membrane sensitive to pH containing ...
CAMPANELLA, Luigi, C. Colapicchioni, FAVERO, Gabriele, SAMMARTINO, Maria Pia, TOMASSETTI, Mauro   +4 more
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In vitro enhancement of aniline metabolism by paraoxon

Toxicology and Applied Pharmacology, 1972
Paraoxon in concentrations from 2 × 10−5 m to 1 × 10−3 m enhanced the in vitro microsomal metabolism of aniline in livers obtained from rats, mice, rabbits, dogs and man. Paraoxon is several thousand times more potent as an enhancing agent than acetone. Enhancement of drug metabolism by acetone is inhibited by SKF 525A, but enhancement of metabolism by
J T, Stevens, J J, McPhillips, R E, Stitzel   +2 more
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