Results 141 to 150 of about 5,226 (177)
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Paraoxon inhibits fertilization of mouse gametes in vitro
Bulletin of Environmental Contamination and Toxicology, 1994Potential exposure of mammals to organophosphate pesticides and their metabolites is recognized (Frank et al. 1991). Organophosphates have been implicated frequently in suboptimal reproductive performance in males and females of various species. Studies have shown that altered androgen metabolism (Krause, 1977), pathological changes in testes and ...
K C, Chou, R M, Cook
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Paraoxon-induced myopathy: Muscle specificity and acetylcholine involvement
Experimental Neurology, 1976Abstract Treatment of rats with Paraoxon, an organophosphorous cholinesterase (ChE) inhibitor, produces a progressive myopathy in skeletal muscle. The earliest stage of lesion development is characterized histologically by heavy trichrome staining of central nuclei with splitting fibers.
L, Wecker, W D, Dettbarn
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Oximes as pretreatment before acute exposure to paraoxon
Journal of Applied Toxicology, 2019AbstractOrganophosphates, useful agents as pesticides, also represent a serious danger due to their high acute toxicity. There is indication that oximes, when administered before organophosphate exposure, can protect from these toxic effects. We have tested at equitoxic dosage (25% of LD01) the prophylactic efficacy of five experimental (K‐48, K‐53, K ...
Dietrich E. Lorke +4 more
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Functionalized graphene oxide for the fabrication of paraoxon biosensors
Analytica Chimica Acta, 2014There is an increasing need to develop biosensors for the detection of harmful pesticide residues in food and water. Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon ...
Hangyu Zhang +4 more
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Paraoxon deethylation in the metabolism of parathion
Pesticide Biochemistry and Physiology, 1972Abstract Monoethyl paraoxon has been shown to be a major in vivo urinary metabolite of parathion with several rat strains. The metabolite was identified by radiometric, chromatographic, and infrared analyses. Rats given monoethyl paraoxon excreted only a portion of the dose whereas practically all diethyl phosphoric acid was recovered in the urine.
Henry T. Appleton, Tsutomu Nakatsugawa
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Catalytic Antibody Mediated Hydrolysis of Paraoxon
The Journal of Organic Chemistry, 1996Brian J., Lavey, Kim D., Janda
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Worker Poisonings Due to Paraoxon Residues
Journal of Occupational and Environmental Medicine, 1977R C, Spear +3 more
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Renal effects of paraoxon in the rat
Bulletin of Environmental Contamination and Toxicology, 1974E, Bowens, J E, Pearson, R L, Williams
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Metoclopramide protection of cholinesterase from paraoxon inhibition.
Veterinary and human toxicology, 2003This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times.
Georg A, Petroianu +4 more
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