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Paraoxonase 1 Gene L55M Polymorphism and Paraoxonase 1 Activity in Obstructive Sleep Apnea Patients
2018The antioxidant enzyme paraoxonase-1 (PON1) may limit oxidative stress in the development of cardiovascular diseases (CVD) and obstructive sleep apnea (OSA). The aim of the study was to determine PON1 gene L55M polymorphism in OSA-positive and OSA-negative subjects, along with paraoxonase activity of the enzyme (PON1-act).
A, Płóciniczak +8 more
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Paraoxonase 1 and Postprandial Lipemia
2008Risk factors for coronary heart disease (CHD) include decreased insulin sensitivity and glucose intolerance, hypertension, increased body fat mass, unfavorable body fat distribution, the prothrombotic state and dyslipidemia. A clustering of these metabolic disturbances is also seen in Insulin Resistance and the metabolic syndrome.
A. Alipour +7 more
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Misunderstandings about paraoxonase-1
2022[No Abstract Available]
Mackness, Michael, Sozmen, Eser Y.
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Paraoxonase-1 and Cardiovascular Disease
2008The oxidation of low-density lipoprotein (LDL) in the artery wall is responsible for the initiation and progression of atherosclerosis. High-density lipoprotein (HDL) on the other hand is protective against atherosclerosis development and can attenuate the oxidation of LDL.
B. Mackness, M.I. Mackness
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Macrophage paraoxonase 1 (PON1) binding sites
Biochemical and Biophysical Research Communications, 2008Paraoxonase 1 (PON1), an HDL-associated esterase, is known to possess anti-oxidant and anti-atherogenic properties. PON1 was shown to protect macrophages from oxidative stress, to inhibit macrophage cholesterol biosynthesis, and to stimulate HDL-mediated cholesterol efflux from the cells. The aim of the present study was to characterize macrophage PON1
Michal, Efrat, Michael, Aviram
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Serum paraoxonase 1 and butyrylcholinesterase in dogs with hyperadrenocorticism
The Veterinary Journal, 2015The aim of this study was to evaluate serum activities of paraoxonase 1 (PON1) using three substrates; (1) 4-nitrophenylacetate (PON1n), (2) phenylacetate (PON1p), and (3) 5-thiobutyl butyrolactonase (PON1t), and butyrylcholinesterase (BChE) in dogs with hyperadrenocorticism (HAC).
Asta, Tvarijonaviciute +5 more
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Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma
Molecular Biology Reports, 2010Paraoxonase is an HDL-associated enzyme that plays a preventive role against oxidative stres. Previous studies suggested that involved an amino acid substitution at position 192 gives rise to two alloenzymes with a low activity (Q allele) and a high activity (R allele) towards paraoxon.
Arzu, Ergen +4 more
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The synthesis and analysis of S-nitorsylated paraoxonase 1
Biochemical and Biophysical Research Communications, 2014Post-translational modification (PTM) of proteins plays a crucial role in health and disease by affecting numerous aspects of protein structure, function, stability and subcellular localization. Protein S-nitrosylation is one type of PTM that involves the covalent modification of cysteine sulfhydryl groups with nitric oxide (NO) and has a regulatory ...
Soliman, Khatib +4 more
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The Role of Paraoxonase 1 in the Detoxification of Homocysteine Thiolactone
2009The thioester homocysteine (Hcy)-thiolactone, product of an error-editing reaction in protein biosynthesis, forms when Hcy is mistakenly selected by methionyl-tRNA synthetase. Accumulating evidence suggests that Hcy-thiolactone plays an important role in atherothrombosis.
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