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Correction to: "MBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug: Phase 1, First-In-Human, Randomized Trial".

J Clin Endocrinol Metab
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Oxidation of parathyroid hormone

Clinica Chimica Acta, 2020
Parathyroid hormone (PTH) is the key hormone regulating calcium homeostasis and, as such, is an important diagnostic and prognostic marker. Although the measurement of PTH has greatly improved over the past few decades, oxidation status thereof is unaccounted for in currently used assays. PTH can be oxidized on methionine residues located at amino acid
Stan R. Ursem, Marc G. Vervloet, Renate T. de Jongh, Annemieke C. Heijboer   +3 more
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Parathyroid hormone

2021
Parathyroid hormone is an essential regulator of extracellular calcium and phosphate. PTH enhances calcium reabsorption while inhibiting phosphate reabsorption in the kidneys, increases the synthesis of 1,25-dihydroxyvitamin D, which then increases gastrointestinal absorption of calcium, and increases bone resorption to increase calcium and phosphate ...
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BIOSYNTHESIS OF PARATHYROID HORMONE

Annals of the New York Academy of Sciences, 1977
Figure 11 summarizes our present concepts of the biosynthetic sequence for parathyroid hormone, deduced largely from observations in vitro. Many aspects of the presumed process whereby preproparathyroid hormone is converted via proparathyroid hormone to the hormone remain unclarified and require much further study, as is true for many other prehormones.
Joel F. Habener, Alexander Rich, Henry M. Kronenberg, John T. Potts   +3 more
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Parathyroid Hormone and Phosphaturia

Calcified Tissue Research, 1975
In 1911, Greenwald reported that urinary phosphate was significantly decreased in parathyroidectomized dogs (3). He was the first to suggest a link between the observed drop in phosphate excretion and the removal of the parathyroid glands. Sixty-four years later, the mechanism by which parathyroid hormone (PTH) enhances phosphaturia is still largely ...
R. J. Midgett, A. B. Borle, T. Uchikawa
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Parathyroid hormone and parathyroid hormone-related peptide, and their receptors

Biochemical and Biophysical Research Communications, 2005
Parathyroid hormone (PTH) has a central role in the regulation of serum calcium and phosphate, while parathyroid hormone-related peptide (PTHrP) has important developmental roles. Both peptides signal through the same receptor, the PTH/PTHrP receptor (a class B G-protein-coupled receptor).
Harald Jüppner, Thomas J. Gardella, Robert C. Gensure   +2 more
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