Results 91 to 100 of about 27,448 (202)

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

Journal of Small Animal Practice, Volume 67, Issue 6, Page 487-491, June 2026.
This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley   +1 more source

Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons

Traffic, Volume 27, Issue 2, June 2026.
Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is poorly understood. Using live‐cell imaging to track vesicle trajectories, combined with machine learning‐based classification, the analysis reveals ...
Beatriz Aznar‐Escolano, Vera Egorova, José Villanueva, Luis Miguel Gutiérrez, Virginia González‐Vélez, Amparo Gil, Sandra Jurado   +6 more
wiley   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, Volume 604, Issue 11, Page 4338-4377, 1 June 2026.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Pituitary Neurolobectomy induces sustained hypotension in male Wistar rats and normalizes blood pressure in male spontaneously hypertensive rats

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Arginine vasopressin is primarily recognized as an osmoregulatory hormone; however, its contribution to vascular tone and blood pressure regulation under basal and hypertensive conditions remains debated. This study examined the effects of vasopressin deficiency induced by neurointermediate pituitary lobectomy in Wistar and spontaneously ...
Gloria Marcela Villanueva‐Rodríguez, Norma A. Bobadilla, J. Luis Quintanar, Claudia Verónica Rivera‐Cerecedo, David Roberto Chavira‐Ramírez, Kalman Kovacs, Andrés Quintanar‐Stephano   +6 more
wiley   +1 more source

Activity‐based anorexia enhances glutamatergic synaptic transmission and neuronal excitability within the nucleus accumbens of female mice

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Anorexia nervosa is a severe psychiatric disorder characterized by persistent food restriction and often excessive physical activity, implicating dysfunction in neural circuits governing motivation, reward, and behavioral persistence. The nucleus accumbens (NAc) is a central component of these circuits, yet synaptic and cellular adaptations ...
Lydia G. Bailey, Connor W. Christensen, Samantha E. Weed, Mohammed Moinul Islam, Amit Thakar, Jaedyn B. Brown, Shane T. Hentges, Travis E. Brown   +7 more
wiley   +1 more source

OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura, Mizuki Fujiwara, Soyoka Horie, Miona Marutani, Eri Nousou, Nanase Iki, Yuka Yamato, Yui Otonashi, Tsutomu Sasaki, Mina Fujitani, Teppei Fujikawa   +10 more
wiley   +1 more source

Relaxin and the Paraventricular Nucleus of the Hypothalamus

, 2013
The hormone relaxin regulates the release of the magnocellular hormones, oxytocin and vasopressin, from the central nervous system. Studies have yet to determine whether relaxin regulates magnocellular hormone release through the circumventricular organs alone, or whether relaxin can act on the brain regions containing the magnocellular neurons as well.
openaire   +1 more source

Substance P-expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus-airway neural pathway. [PDF]

Front Neurosci
Zhang X, Chen J, Lin C, Xiao T, Wu B, He F.   +5 more
europepmc   +1 more source

Paraventricular nucleus-locus coeruleus VGlut2 neural circuit regulates energy metabolism in mice. [PDF]

Cell Death Dis
Liu H, Li P, Yu M, Zhang X, Zhu H, He Y, Zhang Z, Li X, Teng B, Fan J, Yang W, Yin J, Hao Q, Cao G, Li H, Liu S, Li Y, Ren J, Chen Y, Du C.   +19 more
europepmc   +1 more source