Results 31 to 40 of about 361,612 (191)

Role of the hypothalamic paraventricular nucleus in anxiety disorders

Stress and Brain, 2022
The hypothalamic paraventricular nucleus (PVN) expresses multiple neuropeptides and plays an essential role in several physiological processes. Among the brain areas directly projecting to the PVN are deep brain structures closely related to instinctive ...
Chen Wu, Mario A. Zetter
doaj   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the Medial Prefrontal Cortex

Advanced Science, EarlyView.
This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li, Yi‐Ge Guo, Xing Xu, Gui‐Lin Meng, Han Li, Liu‐Wei Chu, Xin‐Yuan Chen, Xiao‐Yun Guo, Tao Xu, Ti‐Fei Yuan, Ji Hu, Xiao‐Na Zhu   +11 more
wiley   +1 more source

Presença de receptores serotonérgicos no núcleo paraventricular do hipotálamo e sua participação no controle neural da ingestão de alimentos em pombos (Columba livia) [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Mestrado em NeurociênciasInvestigação do possível envolvimento de receptores serotonérgicos presentes no Núcleo Paraventricular do Hipotálamo na regulação de ...
Silva, Aderley Serenita Sartori da
core  

Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding

Nature Communications, 2021
Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior ...
Daniel J. Christoffel, Jessica J. Walsh, Boris D. Heifets, Paul Hoerbelt, Sophie Neuner, Gordon Sun, Vinod K. Ravikumar, Hemmings Wu, Casey H. Halpern, Robert C. Malenka   +9 more
doaj   +1 more source

PBN-PVT projections modulate negative affective states in mice

eLife, 2022
Long-lasting negative affections dampen enthusiasm for life, and dealing with negative affective states is essential for individual survival. The parabrachial nucleus (PBN) and thalamic paraventricular nucleus (PVT) are critical for modulating affective ...
Ya-Bing Zhu, Yan Wang, Xiao-Xiao Hua, Ling Xu, Ming-Zhe Liu, Rui Zhang, Peng-Fei Liu, Jin-Bao Li, Ling Zhang, Di Mu   +9 more
doaj   +1 more source

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

Advanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee, Jaeyoung Yoo, Young A. Kim, Zhuodu Wei, Yunseo Lee, Woo‐Jeong Shon, Je Kyung Seong, Seunghee Lee   +7 more
wiley   +1 more source

Distribuição de neurônios imunorreativos à triptofano hidroxilase no tronco encefálico e diencéfalo de pombos (Columba livia) e sua co-localização com serotonina [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasA distribuição de pericários e processos neuronais contendo triptofano hidroxilase (TPH) no tronco encefálico e ...
Meneghelli, Cristiane
core  

Connectivity from OR37 expressing olfactory sensory neurons to distinct cell types in the hypothalamus

Frontiers in Neural Circuits, 2012
Olfactory sensory neurons which express a member from the OR37 subfamily of odorant receptor genes are wired to the main olfactory bulb in a unique monoglomerular fashion; from these glomeruli an untypical connectivity into higher brain centers exists ...
Andrea eBader, Bettina eKlein, Heinz eBreer, Joerg eStrotmann   +3 more
doaj   +1 more source

Neural and molecular investigation into the paraventricular thalamic-nucleus accumbens circuit for pain sensation and non-opioid analgesia

Pharmacological Research, 2023
The paucity of medications with novel mechanisms for pain treatment combined with the severe adverse effects of opioid analgesics has led to an imperative pursuit of non-opioid analgesia and a better understanding of pain mechanisms.
Guangchao Zhang, Mengqiao Cui, Ran Ji, Shiya Zou, Lingzhen Song, Bingqian Fan, Li Yang, Di Wang, Suwan Hu, Xiao Zhang, Tantan Fang, Xiaolu Yu, Jun-Xia Yang, Dipesh Chaudhury, He Liu, Ankang Hu, Hai-Lei Ding, Jun-Li Cao, Hongxing Zhang   +18 more
doaj   +1 more source