Results 111 to 120 of about 186,333,048 (184)

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

Nitric oxide and central autonomic control of blood pressure: a neuroanatomical study of nitric oxide and cGMP expression in the brain and spinal cord [PDF]

, 2008
Essential hypertension is defined as a chronic elevation of blood pressure of unknown cause. Though a definitive trigger for this change in blood pressure has not been established, there is a strong association with an upregulation of sympathetic output
Powers-Martin, Kellysan
core  

Corticotropin-Releasing Factor and the Brain-Gut Motor Response to Stress

Canadian Journal of Gastroenterology, 1999
The characterization of corticotropin-releasing factor (CRF) and CRF receptors, and the development of specific CRF receptor antagonists selective for the receptor subtypes have paved the way to the understanding of the biochemical coding of stress ...
Yvette Taché, Vicente Martinez, Mulugeta Million, Jean Rivier   +3 more
doaj   +1 more source

Voluntary exercise mitigates the effects of peri‐adolescent social isolation on emotion recognition and the oxytocinergic system in male mice

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract Social isolation, particularly during adolescence, is known to affect cognitive, emotional, and social behaviors as well as brain modulatory systems such as the hypothalamic oxytocinergic system. Interestingly, recent evidence indicates that exercise can exert beneficial effects on behaviors through the activation of the oxytocinergic system ...
E. Van Loveren, S. Alfos, S. F. Guu, C. Ducroix‐Crepy, S. Hernández‐Ramírez, G. Ferreira, P. Lafenetre   +6 more
wiley   +1 more source

Species differences in the density of ERα-ir cells in brain areas.

, 2013
(A) Species differences in the density of ERα-ir cells in the anterior hypothalamus (AH), bed nucleus of the striaterminalis (BST), medial preoptic area (MPOA), lateral septum (LS), ventral medial hypothalamus (VMH), arcuate nucleus of the hypothalamus ...
Zuoxin Wang (340906), Yu Wang (12152), Linxi Xu (419495), Zhibin Zhang (102722), Yongliang Pan (419496)   +4 more
core   +1 more source

Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production

, 2020
Evidence has mounted that insulin can be synthesized in various brain regions, including the hypothalamus. However, the distribution and functions of insulin-expressing cells in the hypothalamus remain elusive.
Cho, Jae Hyeon, Yong Chul Bae, Bae, Jin Young, Jaemeun Lee, James D. Johnson, Jin Young Bae, Timothy P. O’Leary, Lee, Jaemeun, Eun-Kyoung Kim, O'Leary, Timothy P., Jae Hyun Cho, Kim, Eun-Kyoung, Johnson, James D., Bae, Yong Chul, Kim, Kyungchan, Kyungchan Kim   +15 more
core   +1 more source

Life‐long cardiorespiratory consequences of early life stress on estrogen actions in female rats

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract Early‐life adversity increases risk for disease with sex‐specific effects on brain development. While the association between early‐life stress and neuropsychiatric disorders is well established, its impact on respiratory health is poorly documented, particularly in females.
Richard Kinkead, Stéphanie Fournier, Luana Tenorio‐Lopes, Danuzia Ambrozio‐Marques   +3 more
wiley   +1 more source

Distribution of MCH perikarya in the mouse hypothalamus.

, 2013
(A) Distribution of MCH/CART-positive and MCH-positive/CART-negative neurons, (respectively represented by green and red dots) on a series of line drawings of coronal sections through the mouse hypothalamus and arranged from rostral to caudal (A1 to A6).
Gabrielle Franchi-Bernard (359652), Annie La Roche (359655), Sophie Croizier (337099), Claude Colard (359653), Fabrice Poncet (359654), Pierre-Yves Risold (337103)   +5 more
core   +1 more source

Cardiovascular responses to NMDA injected into nuclei of hypothalamus or amygdala in conscious rats

, 2000
The nuclei of hypothalamus and amygdala have been shown to be involved in the central cardiovascular homeostasis. Recent studies suggest that glutamate-containing neurons have an important role in the regulation of the central cardiovascular function. In
AKICI, AHMET, ONAT, FİLİZ
core   +1 more source