Results 71 to 80 of about 186,333,048 (184)

Sexually dimorphic dynamics of thyroid axis activity during fasting in rats

Frontiers in Bioscience-Landmark, 2020
Starvation induces tertiary hypothyroidism in adult rodents. Response of the hypothalamus-pituitary-thyroid (HPT) axis to starvation is stronger in adult males than in females.
Patricia Joseph-Bravo, Iván Lazcano, Lorraine Jaimes-Hoy, Mariana Gutierrez-Mariscal, Edith Sanchez-Jaramillo, Rosa María Uribe, Jean-Louis Charli   +6 more
doaj   +1 more source

Investigation of structural and neurobiochemical differences in brains from high-performance and native hen breeds

Scientific Reports, 2023
Selection of livestock has not only led to changes in the level of their performance but also modified their behavior. As a result, within a single species, we have to deal with different behaviors of different breeds.
Kornel Kasperek, Jadwiga Jaworska-Adamu, Aleksandra Krawczyk, Karol Rycerz, Grzegorz Buszewicz, Dominika Przygodzka, Grzegorz Wójcik, Eliza Blicharska, Kamil Drabik, Anna Czech, Łukasz Wlazło, Mateusz Ossowski, Iwona Rozempolska-Rucińska   +12 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Polycystic Ovary Syndrome Pathophysiology: Integrating Systemic, CNS and Circadian Processes

Frontiers in Bioscience-Landmark
The conceptualization of polycystic ovary syndrome (PCOS) has primarily focused on hormonal alterations driven by changes within the hypothalamus and ovarian granulosa cells, with treatment by the contraceptive pill and weight loss.
George Anderson
doaj   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods.

, 2008
International audienceThe paraventricular nucleus complex (Pa) is a component of central neural circuitry that regulates several homeostatic variables.
Bardet, Sylvia, M., Northcutt, Rg, Rubenstein, Jl, Martinez-De-La-Torre, M, Puelles, L.   +4 more
core   +1 more source

The organizational effects of oxytocin on the central expression of estrogen receptor α and oxytocin in adulthood

BMC Neuroscience, 2007
Background Previous studies have demonstrated that neonatal manipulation of oxytocin (OT) has effects on the expression of estrogen receptor α (ERα) and the central production of oxytocin observed in juveniles (at weaning, 21 days of age).
Papademetriou Eros, Yoshida Shigeto, Kramer Kristin M, Cushing Bruce S   +3 more
doaj   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Time-dependent effects of training on cardiovascular control in spontaneously hypertensive rats: role for brain oxidative stress and inflammation and baroreflex sensitivity.

PLoS ONE, 2014
Baroreflex dysfunction, oxidative stress and inflammation, important hallmarks of hypertension, are attenuated by exercise training. In this study, we investigated the relationships and time-course changes of cardiovascular parameters, pro-inflammatory ...
Gustavo S Masson, Tassia S R Costa, Lidia Yshii, Denise C Fernandes, Pedro Paulo Silva Soares, Francisco R Laurindo, Cristoforo Scavone, Lisete C Michelini   +7 more
doaj   +1 more source

Suprachiasmatic Nuclei Grafts Restore the Circadian Rhythm in the Paraventricular Nucleus of the Hypothalamus [PDF]

The Journal of Neuroscience, 2004
The mammalian suprachiasmatic nucleus (SCN) controls the circadian rhythm of many physiological and behavioral events by an orchestrated output of the electrical activity of SCN neurons. We examined the propagation of output signals from the SCN into the hypothalamus, especially into the region of the paraventricular nucleus, through ...
Tousson, E., Meissl, H.
openaire   +3 more sources