Results 191 to 200 of about 12,704 (204)

DNA replication and recovery from replication stress are regulated by PARG catalytic activity and PARG-PCNA condensate formation

Poly(ADP-Ribosyl)ation (PARylierung) ist eine posttranslationale Proteinmodifikation, die eine dynamische Reaktion auf DNA-Schäden und Replikationsstress erlaubt. Die koordinierten Aktivitäten von Poly(ADP-Ribose)-Polymerase 1 (PARP1) und Poly(ADP-Ribose)-Glycohydrolase (PARG) gewährleisten, dass PAR-Ketten eine vorübergehende Modifikation darstellen ...
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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Cancer Cell, 2018
Ewa Gogola, Wouter W Wiegant, Daniel J Vis   +2 more
exaly  

PARG

2011
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PARG

2005
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“PARG Inhibitors’ Success: A Long Way to Go!”

Current Enzyme Inhibition, 2015
Anuradha Pandey, Pooja Makhija, Prakash G.Chandak, Anil Bhanudas Gaikwad   +3 more
openaire   +1 more source

Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity

Experimental Cell Research, 2007
Ralph G Meyer, Mirella L Meyer-Ficca
exaly  

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

Cancer Cell, 2019
Nisha Pillay, Anthony Tighe, Louisa Nelson   +2 more
exaly  

The RHCE*Ce(501A) allele encodes the PARG antigen (RH60)

Transfusion, 2017
Erwin A, Scharberg, Gabi, Rink, Sabine, Roth, Susanne, Seyboth, Ekkehard, Richter, Birgit S, Gathof, Jürgen, Burkhart, Peter, Bugert   +7 more
openaire   +2 more sources

PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways

Cell Death and Disease, 2013
exaly  

PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer

Proceedings of the National Academy of Sciences of the United States of America
Ramya Ravindranathan, Özge Sezin SOMUNCU, Alexandre Balieiro da Costa   +2 more
exaly