Results 161 to 169 of about 5,113 (169)

Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity

Experimental Cell Research, 2007
Ralph G Meyer, Mirella L Meyer-Ficca, Myron K Jacobson   +2 more
exaly  

352 (PB340): Covalent PARG inhibitors show sustained target engagement and superior anticancer activity

European Journal of Cancer
S. Patra, M. Pothuganti, P. Brahmam, G. Kummari, J. Kapaka, V. Sankeshi, A. Kayet, G. Merikapudi, S. Viswanadha   +8 more
openaire   +1 more source

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

EMBO Journal
Christina Andronikou, Kamila Burdová, Cor Lieftink   +2 more
exaly  

Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure

Frontiers in Pharmacology, 2019
Yingbin Fu, Zhuoying Zeng, Linqing Yang   +2 more
exaly  

355 (PB343): Preclinical Candidate SYN608 - a Novel PARG Inhibitor with Excellent Anti-tumor Activity

European Journal of Cancer
S. Shi, X. Tang, H. He, C. Ge, Y. Cui, Y. Xie, C. Kan, S. Liu   +7 more
openaire   +1 more source

PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways

Cell Death and Disease, 2013
exaly  

Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation

NAR Cancer
Camilla Coulson-Gilmer, Samantha Littler, Bethany M Barnes   +2 more
exaly  

PARG inhibition halts cholangiocarcinoma progression via the Hippo pathway and enhances response to chemotherapy and immunotherapy

Journal of Hepatology
Yongsheng Xiao, Qinghai Ye, Peiyi Xie
exaly  

P15-5 Study of novel dual-target inhibitors on tubulin and PARG against castration-resistant prostate cancer

Annals of Oncology
openaire   +1 more source