Results 151 to 160 of about 5,113 (169)

Abstract B022: FORX-428: A best-in class PARG inhibitor with promising anti-tumor activity in preclinical cancer models

Molecular Cancer Therapeutics
Abstract The formation of poly (ADP-ribose) (PAR) chains from NAD+ catalyzed by PARP enzymes is a pivotal posttranslational modification at sites of DNA lesions or stalled replication forks and serves as a scaffold to recruit DNA repair proteins.
Frank Tadashi. Zenke, Ulrich Lücking, Olivier Querolle, Andreas Goutopoulos, Luca Iacovino, Marta Malattia, Alessandro Potenza, Nicolas Bocquet, Alena Freudenmann, Serena Bologna, Vasilis Dionellis, Giacomo Rossetti, Marina Gysin, Hanna Kok, Roxanne Lourman, Jason Clochard, Anika Kuster, Irena Konstantinova, Sotirios Sotiriou, Thanos Halazonetis, Jens Würthner, Tarig Bashir   +21 more
openaire   +1 more source

PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy

Journal of Hepatology, 2022
Zheng Chen, Qiang Zhou, Shufeng Liu
exaly  

Novel cell-permeable PARG inhibitors are selective and sensitize cells to alkylating DNA damage

European Journal of Cancer, 2016
D. James, E. Fairweather, L. Griffiths, G. Hopkins, A. Jordan, A. McGonagle, K. Smith, A. Stowell, I. Waddell, D. Ogilvie   +9 more
openaire   +1 more source

PARG Promotes Esophagus Cancer Cell Metastasis by Activation of the Wnt/β-Catenin Pathway

Biochemical Genetics, 2023
Yalan Wang, Yan Jiaxin, Wang Yalan
exaly  

The interplay of TARG1 and PARG protects against genomic instability

Cell Reports, 2023
Anne R Wondisford, Ivan Ahel
exaly  

Relationship of PARG with PARP, VEGF and b-FGF in colorectal carcinoma

Chinese Journal of Cancer Research: Official Journal of China Anti-Cancer Association, Beijing Institute for Cancer Research, 2009
Ya-Lan Wang
exaly  

Mono‐galloyl glucose derivatives are potent poly(ADP‐ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP‐1‐dependent cell death

British Journal of Pharmacology, 2008
Laura Formentini, Stefano Menichetti, Lisa Giovannelli   +2 more
exaly  

Correction: Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

2019
Gogola, Ewa, Duarte, Alexandra A, de Ruiter, Julian R, Wiegant, Wouter W, Schmid, Jonas A, de Bruijn, Roebi, James, Dominic I, Llobet, Sergi Guerrero, Vis, Daniel J, Annunziato, Stefano, van den Broek, Bram, Barazas, Marco, Kersbergen, Ariena, van de Ven, Marieke, Tarsounas, Madalena, Ogilvie, Donald J, van Vugt, Marcel, Wessels, Lodewyk F A, Bartkova, Jirina, Gromova, Irina, Andújar-Sánchez, Miguel, Bartek, Jiri, Lopes, Massimo, van Attikum, Haico, Borst, Piet, Jonkers, Jos, Rottenberg, Sven   +26 more
openaire   +2 more sources

PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion

FASEB Journal, 2005
Salvatore Cuzzocrea, Rosanna Di Paola, Emanuela Mazzon   +2 more
exaly  

Targeting PARG reduces M2 polarization critical for PARP inhibitor resistance in ovarian cancer

Gynecologic Oncology
Rosemarie Martinez Borrero, Antons Martincuks, Hua Yu, Lorna Rodriguez-Rodriguez   +3 more
openaire   +1 more source