Results 151 to 160 of about 3,357,233 (168)

PARG inhibition halts cholangiocarcinoma progression via the Hippo pathway and enhances response to chemotherapy and immunotherapy

Journal of Hepatology
Hui Li, Ye Qinghai, Peiyi Xie
exaly  

2,4-DIOXO-1,4-DIHYDROQUINAZOLINE DERIVATIVES AS PARG INHIBITORS FOR THE TREATMENT OF CANCER

2023
LÜCKING ULRICH, GOUTOPOULOS ANDREAS, XU ZAIXU, SOTIRIOU SOTIRIOS, IACOVINO LUCA, FREUDENMANN ALENA, QUEROLLE OLIVIER   +6 more
openaire   +2 more sources

2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

2016
MCGONAGLE ALISON E, JORDAN ALLAN, WASZKOWYCZ BOHDAN, HUTTON COLIN, WADDELL IAN, HITCHIN JAMES R, SMITH KATE MARY, HAMILTON NIALL M   +7 more
openaire   +2 more sources

Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation

NAR Cancer
Anthony Tighe, Bethany Barnes, Richard Unwin   +2 more
exaly  

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

EMBO Journal
Hendrik Johannes Kuiken, Jos Jonkers, Roderick Beijersbergen   +2 more
exaly  

NOVEL PARG INHIBITORS

LÜCKING ULRICH, QUEROLLE OLIVER, GOUTOPOULOS ANDREAS, XU ZAIXU, IACOVINO LUCA, FREUDENMANN ALENA   +5 more
openaire   +1 more source

PARG inhibition induces nuclear aggregation of PARylated PARP1

Structure
Ranjit Bindra, Ranjini Sundaram, Sateja Paradkar   +2 more
exaly  

352 (PB340): Covalent PARG inhibitors show sustained target engagement and superior anticancer activity

European Journal of Cancer
S. Patra, M. Pothuganti, P. Brahmam, G. Kummari, J. Kapaka, V. Sankeshi, A. Kayet, G. Merikapudi, S. Viswanadha   +8 more
openaire   +1 more source

COMBINATION THERAPY WITH A PARG INHIBITOR

NEILAN CLAIRE L, MUNOZ DELGADO DIANA MARCELA, WHITE MICHAEL ANTHONY, MASKEY REEJA   +3 more
openaire   +1 more source

NOVEL BICYCLO HETEROARYL PARG INHIBITORS

LÜCKING ULRICH, QUEROLLE OLIVIER, GOUTOPOULOS ANDREAS, IACOVINO LUCA, ROSSETTI GIACOMO, GYSIN MARINA, MALATTIA MARTA, KONSTANTINOVA IRENA, ZENKE FRANK, BOCQUET NICOLAS, BASHIR TARIG, KOK HANNA, JIN TIAN   +12 more
openaire   +1 more source