Results 131 to 140 of about 6,510 (175)

RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining. [PDF]

Exp Mol Med
Hussain M, Khadka P, Pekhale K, Kulikowicz T, Gray S, May A, Croteau DL, Bohr VA.   +7 more
europepmc   +1 more source

Screening the Pandemic Response Box identifies novel ligands of the Staphylococcus aureus protein arginine kinase, McsB. [PDF]

Mol Biol Rep
Chetty R, Delport A, Mthembu S, Veale CGL, Hewer R.   +4 more
europepmc   +1 more source

Bifendate inhibits cell PARthanatos by activating the MEK/ERK pathway. [PDF]

Biochem Biophys Rep
Hu AM, Chen M, Zhu CC, Zhu ZM, Xu XH.
europepmc   +1 more source

O-GlcNAcylation of the tumor suppressor LATS1 drives mitotic progression via PLK1. [PDF]

J Biol Chem
Meng L, Wang Y, Zhou W, Wu S, Li J.
europepmc   +1 more source

Protocol for synthesizing and purifying short-length poly(ADP)ribose polymer using fast protein liquid chromatography. [PDF]

STAR Protoc
Neeharika S, Hanuman DS, Rajakumara E.
europepmc   +1 more source

Liquid‒liquid phase separation and poly(ADP‒ribosyl)ation in the context of ultraviolet radiation-induced stress in mammalian cells. [PDF]

Biophys Rev
Mejías D, Seballos V, Lafon-Hughes L.
europepmc   +1 more source

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Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat

Brain Research, 2003
Poly(ADP-ribose) is synthesized from nicotinamide adenine dinucleotide (NAD(+)) by poly(ADP-ribose) polymerase (PARP) and degraded by poly(ADP-ribose) glycohydrolase (PARG). Overactivation of the poly(ADP-ribose) pathway increases nicotinamide and decreases cellular NAD(+)/ATP, which leads to cell death.
Xi-Chun M, Lu, Edmond, Massuda, Qian, Lin, Weixing, Li, Jia-He, Li, Jie, Zhang   +5 more
exaly   +3 more sources

DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy

Progress in Biophysics and Molecular Biology, 2021
Poly (ADP-ribosyl)ation has central functions in maintaining genome stability, including facilitating DNA replication and repair. In cancer cells these processes are frequently disrupted, and thus interfering with poly (ADP-ribosyl)ation can exacerbate inherent genome instability and induce selective cytotoxicity. Indeed, inhibitors of poly (ADP-ribose)
Nisha Pillay, Rosie M. Brady, Malini Dey, Robert D. Morgan, Stephen S. Taylor   +4 more
openaire   +4 more sources

Efficient synthesis of imidazo[1,5-a]pyridine sulfonamido derivative as a PARG inhibitor

Tetrahedron
Chao Kan, Chongxun Ge, Song Liu, Song Shi, Hu He, Weike Su   +5 more
exaly   +2 more sources