Results 121 to 130 of about 5,113 (169)

Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in <i>C. elegans</i>. [PDF]

Elife
Raices M, Balmir F, Silva N, Li W, Grundy MK, Hoffman DK, Altendorfer E, Camacho CJ, Bernstein KA, Colaiacovo MP, Yanowitz JL.   +10 more
europepmc   +1 more source

DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy

Progress in Biophysics and Molecular Biology, 2021
Poly (ADP-ribosyl)ation has central functions in maintaining genome stability, including facilitating DNA replication and repair. In cancer cells these processes are frequently disrupted, and thus interfering with poly (ADP-ribosyl)ation can exacerbate inherent genome instability and induce selective cytotoxicity. Indeed, inhibitors of poly (ADP-ribose)
Nisha Pillay, Rosie M. Brady, Malini Dey, Robert D. Morgan, Stephen S. Taylor   +4 more
core   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat

Brain Research, 2003
Poly(ADP-ribose) is synthesized from nicotinamide adenine dinucleotide (NAD(+)) by poly(ADP-ribose) polymerase (PARP) and degraded by poly(ADP-ribose) glycohydrolase (PARG). Overactivation of the poly(ADP-ribose) pathway increases nicotinamide and decreases cellular NAD(+)/ATP, which leads to cell death.
Jia-He Li
exaly   +3 more sources

A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation

Analytical Biochemistry, 2004
The enzyme poly(ADP-ribose) glycohydrolase (PARG) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units. Thus, in conjunction with poly(ADP-ribose) polymerase (PARP), PARG activity regulates the extent of in vivo poly(ADP-ribosyl)ation.
Karson S Putt, Paul J Hergenrother
exaly   +3 more sources

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors [PDF]

Progress in Biophysics and Molecular Biology, 2021
Arrival of the novel SARS-CoV-2 has launched a worldwide effort to identify both pre-approved and novel therapeutics targeting the viral proteome, highlighting the urgent need for efficient drug discovery strategies.
Chris A Brosey, Panagiotis Katsonis, Shobanbabu Bommagani   +2 more
exaly   +2 more sources

Efficient synthesis of imidazo[1,5-a]pyridine sulfonamido derivative as a PARG inhibitor

Tetrahedron
Weike Su
exaly   +2 more sources

PARG Inhibitors and Functional PARG Inhibition Models

Current Protein & Peptide Science, 2016
Poly(ADP-ribose) polymerases (PARPs) family proteins catalyze poly(ADP-ribosylation) (PARylation) by conjugating ADP-ribose residues repeatedly on amino acid residues using nicotinamide adenine dinucleotide as a substrate. The inhibitors of PARP widely block DNA repair processes and are currently examined in clinical trials of cancer therapy.
Yuka, Sasaki, Miyuki, Hozumi, Hiroaki, Fujimori, Yasufumi, Murakami, Fumiaki, Koizumi, Kengo, Inoue, Mitsuko, Masutani   +6 more
openaire   +2 more sources

Cell-Based Screening for New PARP Inhibitors Utilizing PARG-Mutated Mouse Embryonic Stem Cells

2022
According to the most recent data, cancer is among the leading cause of death in the United States and accounted for more than 600,000 deaths in 2021. Around 30% of these cancer-related deaths were caused by breast, prostate, and ovarian cancers. PARP-1 inhibitors show the most promising results in treatment of these three types of cancers and have ...
Yaroslava, Karpova, Danping, Guo, Alexei V, Tulin   +2 more
openaire   +2 more sources