Results 81 to 90 of about 6,510 (175)

Supplementary Figure S6. PARG overexpression rescues HuR's regulation of PARPi response from Posttranscriptional Regulation of <i>PARG</i> mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors

, 2023
<p>PARG rescue in HuR silenced cells restores PARPi resistance. Small-molecule inhibition of HuR prevents its cytoplasmic accumulation, abrogates PARG mRNA regulation and increases PARPi sensitivity, independent of DDR status.</p>
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand   +17 more
openaire   +1 more source

Nitrosative stress and pharmacological modulation of heart failure [PDF]

, 2005
Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and ...
Liaudet, L., Pacher, P., Schulz, R., Szabo, C.   +3 more
core   +1 more source

The genome sequence of Pseudoplusia includens single nucleopolyhedrovirus and an analysis of p26 gene evolution in the baculoviruses [PDF]

, 2015
Background: Pseudoplusia includens single nucleopolyhedrovirus (PsinSNPV-IE) is a baculovirus recently identified in our laboratory, with high pathogenicity to the soybean looper, Chrysodeixis includens (Lepidoptera: Noctuidae) (Walker, 1858). In Brazil,
Báo, Sônia Nair, Castro, Maria Elita Batista de, Craveiro, Saluana Rocha, Grynberg, Priscila, Inglis, Peter W., Melo, Fernando Lucas, Ribeiro, Bergmann Morais, Ribeiro, Zilda Maria de Araújo, Togawa, Roberto Coiti   +8 more
core   +2 more sources

The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]

, 2015
The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika, Nikiforov, Andrey, Ziegler, Mathias   +2 more
core   +2 more sources

A poli(ADP-ribóz) polimeráz-2 szerepének vizsgálata a SIRT1 aktivációjában, az energiaháztartásban és a sejtek NAD+ koncentrációjának modulálásában = Investigation of the role of poly(ADP-ribose) polymerase-2 in SIRT1 activation, energy expenditure and the modulation of cellular NAD+ concentrations [PDF]

, 2011
A projekt során a poli(ADP-ribóz polimeráz (PARP) enzimek metabolikus szerepét vizsgálatuk. A PARP-1-/- egerekben a harántcsíkolt izomban és a barna zsírszövetben emelkedett biológiai oxidációt tapasztaltunk.
Bai, Péter, Brunyánszki, Attila, Hegedűs, Csaba, Kovács, Katalin, Virág, László   +4 more
core  

A foszforilációs-defoszforilációs jelátviteli útvonalak kölcsönhatásai a szabad gyökök által kiváltott jelátviteli pályákkal = Cross-talk between phosphorylation-dephosphorylation and free radical-mediated signal transduction pathways [PDF]

, 2006
A peroxinitrit humán keratinocita (HaCaT) sejtekben intracelluláris kalcium mobilizációt okoz. Igazoltuk a kalcium mobilizáció szerepét mind az apoptotikus, mind a nekrotikus sejthalálban.
Bai, Péter, Bakó, Éva, Gergely, Pál, Módis, László, Sipka, Sándor, Szűcs, Kornélia, Virág, László, Zákány, Róza   +7 more
core  

ARTD2 activity is stimulated by RNA [PDF]

, 2017
ADP-ribosyltransferases (ARTs) are important enzymes that regulate the genotoxic stress response and the maintenance of genome integrity. ARTD1 (PARP1) and ARTD2 (PARP2) are homologous proteins that modify themselves and target proteins by the addition ...
Bär, Dominik, Hottiger, Michael O., Léger, Karolin, Santoro, Raffaella, Savić, Nataša   +4 more
core  

Új mechanizmusok azonosítása az oxidatív stressz indukálta mitokondrium-függő nekrotikus sejthalálban = Identification of novel mechanisms in the oxidative stress induced mitochondria-related necrotic cell death [PDF]

, 2013
Oxidatív stress körülményei között kimutattuk, hogy a PARP enzim gátlása növeli az MKP-1 expresszióját (ez a foszfatáz felelős elsődlegesen a JNK és p38 MAPK inaktivációjáért), ezért szerepet játszhat a PARP gátlás mediálta mitokondriális védelem ...
Bognár, Zita, Gallyas, Ferenc, Kovács, Krisztina, Ohmacht, Róbert, Radnai, Balázs, Rácz, Boglárka, Sümegi, Balázs, Tucsek, Zsuzsanna, Veres, Balázs   +8 more
core  

Effect of putative PARG inhibitors identified by an in silico approach on Trypanosoma cruzi infection

, 2019
Fil: Fernandez Villamil, Silvia Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N.
Svagzdys, Ailin, Vilchez Larrea, Salomé Catalina, Alberca, Lucas Nicolás, Caram, Franco, Talevi, Alan, Fernandez Villamil, Silvia Hebe   +5 more
openaire   +1 more source

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis. [PDF]

NAR Cancer
Ibrahim M, Roos WP, Schwartz JC, Khan MM, Al-Rahahleh RQ, Beers LA, Pearson CR, Langham KT, Boyang L, Clark J, Hayat F, Fang Q, Koczor CA, Migaud ME, Sobol RW.   +14 more
europepmc   +1 more source