Results 81 to 90 of about 5,113 (169)

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis. [PDF]

NAR Cancer
Ibrahim M, Roos WP, Schwartz JC, Khan MM, Al-Rahahleh RQ, Beers LA, Pearson CR, Langham KT, Boyang L, Clark J, Hayat F, Fang Q, Koczor CA, Migaud ME, Sobol RW.   +14 more
europepmc   +1 more source

Structural and biochemical studies of protein poly(ADP-ribosyl)ation

, 2012
Thesis (Ph.D.)--University of Washington, 2012Protein poly(ADP-ribosyl)ation (PARylation) has been found to be involved in various cellular processes, such as DNA damage recognition and repair, chromatin structure dynamics, gene transcription and poly ...
Wang, Zhizhi
core  

Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3

Poly-ADP-ribosylation at sites of DNA damage, catalyzed by PARP enzymes, activates the DNA damage response, chromatin remodeling, and DNA repair. The modification is reversed by two enzymes in humans: PARG, which efficiently hydrolyzes the poly-ADP ...
Parviainen, Tomi A O, Duong, Men Thi Hoai, Lehtiö, Lari, Hanzlikova, Hana, Pääkkönen, Johan, Heiskanen, Juha P, Burdova, Kamila, Kuttichova, Barbora   +7 more
core   +1 more source

PARG inhibition in ATM-deficient prostate cancer: from mechanistic discovery to therapeutic potential. [PDF]

J Transl Med
Zhou X, Guo C, Fan Z, Lou Y, Yue Z, Xu W, Xin Z, Ren S.   +7 more
europepmc   +1 more source

CHD1L maintains genome integrity by facilitating okazaki fragment maturation. [PDF]

Nucleic Acids Res
Nie L, Fu J, Huang M, Zhang H, Ma T, Yang C, Li S, Wang C, Chen J.   +8 more
europepmc   +1 more source

Poly(ADP-ribose) glycohydrolase enforces p21 degradation via dePARylation to promote gastric cancer progression. [PDF]

J Clin Invest
Hu Y, Bao Q, Huang Y, Wang Y, Zhao X, Nan J, Meng Y, Deng M, Li Y, Zhuang Z, He H, Zu D, Zhong Y, Zhang C, Wang B, Li R, He Y, Wang Q, Liu M, Tainer JA, Shi Y, Cheng X, Jing J, Ye Z.   +23 more
europepmc   +1 more source

Targeting MARylation and DePARylation in Cancer Therapy: New Promising Therapeutic Opportunities. [PDF]

Cancers (Basel)
Cabeza-Fernández V, Ríos-Sola FJ, Martín-Oliva D, Borrego-Pérez J, Oliver FJ, YéLamos J, Rodríguez-Vargas JM.   +6 more
europepmc   +1 more source

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling. [PDF]

Nat Commun
Dauben H, Mihaljević M, Kolvenbach A, Palumbieri MD, Kapsali C, Huppertz I, Matić I.   +6 more
europepmc   +1 more source

The Expanding Landscape of ADP-Ribosylation: Protein, DNA, RNA, and Mitochondrial Regulation. [PDF]

Chem Res Toxicol
Sin YC, Zhao L.
europepmc   +1 more source

PARP-2 catalytic activity drives replication-ICL repair in an allele-specific manner during germline development. [PDF]

PLoS Genet
Ren X, Hu A, Liu Z, Kim S, Kim HM.
europepmc   +1 more source