Results 61 to 70 of about 6,510 (175)

Attitudes to aging are associated with cognition and biomarker status in older adults at risk for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S4, December 2025.
Abstract Background Attitudes toward aging influence longevity as well as physical and psychological health, yet their relationship with cognition and Alzheimer's disease (AD) remains largely unknown. We hypothesized that positive attitudes toward aging would predict better cognition and diminished risk on AD blood‐based biomarker profiles in older ...
Franciska Otaner, Caitlin S. Walker, Adrián Noriega de la Colina, Linda Li, Carolynn Boulanger, Nagashree Thovinakere, Alix Noly‐Gandon, Garance Barnoin, Mitchell Bennett, Jillian Caplan, Laurence Côté, Sarah Elbaz, Shania Fock Ka Bao, Ryan Kara, Nicolas Lavoie, Maggie Nguyen, Helen Pallett‐Wiesel, Johanie Victoria Piché, Andreanne Powers, Sofia Ricciardelli, Kayla Williams, Christine Dery, Jennifer Tremblay‐Mercier, Judes Poirier, Sylvia Villeneuve, Arthur F. Kramer, Maiya R. Geddes, PREVENT‐AD Research Group   +27 more
wiley   +1 more source

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death [PDF]

, 2018
Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG).
Althaus, Felix, Bader, J., Blenn, C., Bollhalder, M., Wyrsch, P.   +4 more
core  

Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA [PDF]

, 2008
The affinity of the poly(ADP-ribose) polymerase-1 (PARP-1) for platinum-damaged DNA was first discovered during photo-cross-linking experiments using the photoactive compound Pt-BP6 [J. Am. Chem. Soc.
Guggenheim, Evan R., Lippard, Stephen J., Movassaghi, Mohammad, Ondrus, Alison E.   +3 more
core   +2 more sources

Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells [PDF]

, 2018
Differentiation of blood cells is one of the most complex processes in the body. It is regulated by the action of transcription factors in time and space which creates a specific signaling network.
Antica, Mariastefania, Horvat, Luka, Matulić, Maja   +2 more
core   +2 more sources

Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications

MedComm, Volume 6, Issue 12, December 2025.
Single‐cell sequencing has elucidated cell‐type‐specific transcriptional alterations, activated signaling pathways, metabolic reprogramming, immune infiltration, and chromatin‐associated genetic mechanisms in IPF, uncovering novel therapeutic targets.
Lin Zuo, Qiongliang Liu, Defeng Ye, Jiang Fan, Liang Wu   +4 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Inhibitors of poly(ADP-ribose) glycohydrolase (PARG) exhibit single agent therapeutic activity and sensitize glioblastoma cells to ionizing radiation [PDF]

Neuro-Oncology, 2019
Abstract Objective The lack of an effective therapy for glioblastoma (GBM) largely results from the intrinsic resistance of GBM cells. The radiosensitizing activity of inhibitors of poly(ADP-ribose) polymerases (PARPs) highlights the important role of poly(ADP-ribose) (PAR) in the DNA damage response.
Jackson, Mark, Gomez-Roman, Natividad, Chalmers, Anthony   +2 more
openaire   +2 more sources

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes [PDF]

, 2009
Maintaining the integrity of sperm DNA is vital to reproduction and male fertility. Sperm contain a number of molecules and pathways for the repair of base excision, base mismatches and DNA strand breaks.
Ashok Agarwal, Reda Z Mahfouz, Rakesh K Sharma, Oli Sarkar, Devna Mangrola, Premendu P Mathur, T Ogawa, F Suzuki-Toyota, K Toshimori, RJ Aitken, I Amiri, F Kappes, DN Tripathi, D Sakkas, P Patrizio, E Seli, J Tesarik, MM El-Domyati, RM Laberge, RM Laberge, F Leduc, RK Sharma, A Agarwal, A Agarwal, A Agarwal, A Agarwal, M Bungum, J Erenpreiss, M Muratori, SE Lewis, K Tremellen, TE Schmid, KC Chitra, P Mathur, AK Olsen, JC Rockett, B Saradha, N Desai, A Agarwal, D Gero, JP Gagne, AM Reed, S Di Meglio, AP Sinha Hikim, ML Meyer-Ficca, L Atorino, D Sakkas, O Stahl, RZ Mahfouz, SE Lewis, A Zini, S Horak, Z Li, MH Nasr-Esfahani, C Niederberger, C Paul, V Schreiber, C Flohr, JC Ame, PO Hassa, DA Wacker, V Schreiber, A Augustin, M Baumgartner, BW Cherney, BC Woodhouse, D D'Amours, PO Hassa, MF Langelier, Z Tao, V Schreiber, E Pion, M Altmeyer, T Zaremba, N Ogata, J Diefenbach, H Mendoza-Alvarez, P Adamietz, GG Poirier, L Atorino, H Mendoza-Alvarez, K Yoshihara, AI Scovassi, M Kameoka, K Huang, PI Bauer, U Kolthur-Seetharam, G Ermak, T Schwerdtle, R Midorikawa, E Mocchegiani, E Kun, L Geraets, TM Kauppinen, Y Ariumi, M Audebert, J Chen, P Kotoglou, JB Leppard, F Dantzer, JL Parsons, D Sagan, D Quenet, O Mortusewicz, O Ullrich, J Mathieu, JT Heeres, FJ Oliver, M Zerfaoui, SH Kaufmann, D D'Amours, SW Yu, F Tramontano, A Tulin, NA Berger, SA Andrabi, M Kanai, P Chang, M Kanai, E Earle, A Saxena, MR Faraone-Mennella, WL Kraus, WL Kraus, D Quenet, JY Huang, GG Poirier, M Rouleau, R Krishnakumar, SL Oei, T Yazawa, K Ye, K Mizuno, O Varisli, M Tanori, V Spina-Purrello, W Yu, NA Thornberry, O Ullrich, E Klenova, T Guastafierro, E Winstall, L Davidovic, DW Koh, C Blenn, AE Fisher, JS Baum, CG Print, VA Codelia, Y Ohashi, V Spina-Purrello, M Tewari, P Pacher, PJ Duriez, F Hadziselimovic, WW Lin, SK Kim, J Tesarik, BB Maymon, F Dantzer, AP Hikim, M Miura, R Aguilar-Quesada, V Pentikainen, A Chiarugi, S Di Meglio, P Quesada, D Wouters-Tyrou, WS Ward, L Marcon, ML Meyer-Ficca, A Kaipia, SL Taylor, R Jha, M Benchaib, J Kopeika, M Meseguer, C O'Flaherty, A Edelstein, JR Spermon, RT Mitchell, T Wang, Y Wang, GJ Olsen, IV Kovtun, IV Kovtun, IV Kovtun, E Trushina, D Rybaczek, F Leduc, P Quesada, F Tramontano, S Jaroudi, C Marchetti, U Paasch, S Grunewald, C Almeida, SL Weng, U Paasch, L Faleiro, B Buelow, B Xu, G Blanc-Layrac, MM El-Domyati, RZ Mahfouz, JC Kefer, K Makker, M Reddy, R Mahfouz, S Vaithinathan, O Sarkar, B Saradha, O Sarkar, K Erdelyi, H Chen, PG Chandak, SF El-Khamisy, Y Liang, M Ljungman, SH Huang, P Lin, Q Ma, S Beneke, O Cohausz, HJ Chiu, F Dantzer, M Gomez, S Smith, CM Simbulan-Rosenthal, F d'Adda di Fagagna, RJ Aitken, RJ Aitken, RZ Mahfouz, S Adhikari, CA de la Lastra, P Zhang   +235 more
core   +1 more source

Barriers and opportunities for consumption of invasive lionfish in Belize

People and Nature, Volume 7, Issue 11, Page 2777-2793, November 2025.
Abstract Invasive lionfish (Pterois spp.) have rapidly spread across the Western Atlantic and Mediterranean Sea. They reproduce frequently and consume native marine life important to livelihoods and reef health. To combat the deleterious impacts of this species, management efforts in Belize and throughout the invaded range have included development of ...
Kaylin R. Clements, Julie Sabattis, Jennifer K. Chapman, Phil P. Krening, Marc L. Fruitema, Kelly D. Martin, Jennifer N. Solomon   +6 more
wiley   +1 more source

Untargeted Proteomics Identifies Plant Substrates of the Bacterial‐Derived ADP‐Ribosyltransferase AvrRpm1

Plant Direct, Volume 9, Issue 11, November 2025.
ABSTRACT One class of enzymes that plant pathogens employ to manipulate innate immunity and physiology of the infected cells is host‐targeted ADP‐ribosyltransferases. The bacterial pathogen Pseudomonas syringae uses its Type III secretion system to inject several effector proteins with ADP‐ribosyltransferase activity into plant cells.
Simranjit Kaur, Thomas Colby, Domenika Thieme, Carsten Proksch, Susanne Matschi, Ivan Matić, Lennart Wirthmueller   +6 more
wiley   +1 more source