Results 61 to 70 of about 5,113 (169)

Supplementary Figure S3. HuR regulates PARG mRNA expression from Posttranscriptional Regulation of <i>PARG</i> mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors

, 2023
<p>HuR regulates all isoforms of PARG by binding a discrete minimal binding region (MBR) within its 3'UTR in both DDR- proficient MIA PaCa-2 and DDR- deficient Hs 766t cells. Such PARG mRNA and protein expression is also increased with other non-PARPi stress such as gemcitabine and oxaliplatin treatment, which simultaneously induce HuR ...
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand   +17 more
openaire   +1 more source

Inhibitors of poly(ADP-ribose) glycohydrolase (PARG) exhibit single agent therapeutic activity and sensitize glioblastoma cells to ionizing radiation [PDF]

, 2019
Objective The lack of an effective therapy for glioblastoma (GBM) largely results from the intrinsic resistance of GBM cells. The radiosensitizing activity of inhibitors of poly(ADP-ribose) polymerases (PARPs) highlights the important role of poly(ADP ...
Gomez-Roman, Natividad, Jackson, Mark, Chalmers, Anthony   +2 more
core  

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

, 2001
Excessive activation of poly(ADP-ribose) polymerase 1 (PARP1) leads to NAD(+) depletion and cell death during ischemia and other conditions that generate extensive DNA damage.
Weihai Ying, Mary B. Sevigny, Raymond A. Swanson, Yongmei Chen, Sevigny, Mary B., Ying, Weihai, Chen, Yongmei, Swanson, Raymond A   +7 more
core   +1 more source

Untargeted Proteomics Identifies Plant Substrates of the Bacterial‐Derived ADP‐Ribosyltransferase AvrRpm1

Plant Direct, Volume 9, Issue 11, November 2025.
ABSTRACT One class of enzymes that plant pathogens employ to manipulate innate immunity and physiology of the infected cells is host‐targeted ADP‐ribosyltransferases. The bacterial pathogen Pseudomonas syringae uses its Type III secretion system to inject several effector proteins with ADP‐ribosyltransferase activity into plant cells.
Simranjit Kaur, Thomas Colby, Domenika Thieme, Carsten Proksch, Susanne Matschi, Ivan Matić, Lennart Wirthmueller   +6 more
wiley   +1 more source

Supplementary Figure S2. HuR binds and stabilizes PARG mRNA from Posttranscriptional Regulation of <i>PARG</i> mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors

, 2023
<p>HuR directly binds and regulates poly-ADP ribose glycohydrolase mRNA expression particularly under PARPi stress, but doesn't affect expression of other PAR polymerases or hydrolyzing enzymes.</p>
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand   +17 more
openaire   +1 more source

Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide

, 2005
Disruption of poly(ADP-ribose) polymerase (PARP) pathways by inhibitors of PARP catalytic domain has been shown to increase the anti-tumour activity of temozolomide (TMZ).
Tentori, L, GRAZIANI, GRAZIA, Forini, O, Gold, B, Vergati, M, TENTORI, LUCIO, Lacal, P, Graziani, G, Lacal, PM, Leonetti, C, Scarsella, M, Muzi, A, Li, W, MUZI, ALESSIA, Ruffini, F, Zhang, J   +15 more
core   +1 more source

Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.

, 2004
The metabolism of poly(ADP-ribose) (PAR) is critical for genomic stability in multicellular eukaryotes. Here, we show that the failure to degrade PAR by means of disruption of the murine poly(ADP-ribose) glycohydrolase (PARG) gene unexpectedly causes ...
Wattler, S., Poirier, G.G., Lawler, A.M., Nehls, M.C., Stöger, T., Poitras, M.F., Koh, D.W., Sasaki, M., Dawson, V.L., Dawson, T.M.   +9 more
core   +1 more source

Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers

, 2021
Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers.
Ali, Reem, Abdel-Fatah, Tarek, Moseley, Paul, Toss, Michael S., Alabdullah, Muslim L., Chan, Stephen, Madhusudan, Srinivasan, Alblihy, Adel, Miligy, Islam M., Alsaleem, Mansour, Mongan, Nigel P., Rakha, Emad A., Narayan, Satya, Algethami, Mashael   +13 more
core   +1 more source

Targeting Poly (ADP) Ribose Glycohydrolase as a Combinatorial Strategy to Enhance DNA Damage in Gastrointestinal Cancers

, 2021
The DNA damage response (DDR) pathway sets the stage for tumorigenesis and provides both an opportunity for drug efficacy and resistance. Therapeutic approaches to target the DDR pathway include; increasing cytotoxic chemotherapies\u27 effectiveness and ...
Agostini, Lebaron C
core  

Poly(ADP-Ribosyl)ation and genome integrity,role of Poly(ADP-Ribose) Glycohydrolase (PARG) in DNA repair and replication

, 2011
La PARG est une enzyme dégradant un polymère d'ADP riboses, PAR, dont la synthèse est catalysée par les PARPs, formant une famille de 17 protéines codées par 17 gènes différents.
Fouquerel, Elise
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