Results 41 to 50 of about 3,357,233 (168)

Insects and non‐woody plants slow down tropical forest succession: A community‐wide experiment in Papua New Guinea

Journal of Ecology, Volume 114, Issue 4, April 2026.
The importance of top‐down insect herbivory decreased, while the importance of bottom‐up plant competition with non‐woody plant species increased with elevation, representing a gradient of increasing environmental stress in the succession of woody plants.
Kari Sogera Iamba, Piotr Szefer, Kenneth Molem, Austin Sau, Gibson Maiah, Vojtech Novotny   +5 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, Volume 20, Issue 3, Page 779-803, March 2026.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

TSG101 Promotes SIAH1 Auto‐Ubiquitination to Drive Migration and Invasion in Hepatocellular Carcinoma Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Our previous studies have demonstrated that seven in absentia homologue 1 (SIAH1), an E3 ubiquitin ligase, is downregulated in hepatocellular carcinoma (HCC) and regulates substrate ubiquitination. However, the molecular mechanisms governing reduced SIAH1 expression in HCC remain unclear.
Jie Qiu, Xixi Gu, Kai Wu, Jinzhao Wu, Chenrui Xu, Wengang Shan, Hengliang Shi   +6 more
wiley   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Evaluation of the therapeutic efficacy of the dextromethorphan–bupropion combination and its mediating pathways in a mouse model of major depressive disorder

Frontiers in Pharmacology
BackgroundMajor depressive disorder (MDD) is associated with multiple pathophysiological mechanisms, including dysregulation of monoaminergic systems, excessive glutamatergic activity, reduced neurotrophic support, inflammation, and oxidative stress. The
İlay Buran Kavuran, Ebru Önalan, Zeliha İrem Türk, Hatice Eröksüz   +3 more
doaj   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Programmable Hydrogels: Frontiers in Dynamic Closed‐Loop Systems, Biomimetic Synergy, and Clinical Translation

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang, Bohan Yin, Behzad Shiroud Heidari, George Youssef, Monika Gosecka, Mateusz Gosecki, Fernando G. Torres, Siu Hong Dexter Wong, Jagan Mohan Dodda   +8 more
wiley   +1 more source

Attitudes to aging are associated with cognition and biomarker status in older adults at risk for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S4, December 2025.
Abstract Background Attitudes toward aging influence longevity as well as physical and psychological health, yet their relationship with cognition and Alzheimer's disease (AD) remains largely unknown. We hypothesized that positive attitudes toward aging would predict better cognition and diminished risk on AD blood‐based biomarker profiles in older ...
Franciska Otaner, Caitlin S. Walker, Adrián Noriega de la Colina, Linda Li, Carolynn Boulanger, Nagashree Thovinakere, Alix Noly‐Gandon, Garance Barnoin, Mitchell Bennett, Jillian Caplan, Laurence Côté, Sarah Elbaz, Shania Fock Ka Bao, Ryan Kara, Nicolas Lavoie, Maggie Nguyen, Helen Pallett‐Wiesel, Johanie Victoria Piché, Andreanne Powers, Sofia Ricciardelli, Kayla Williams, Christine Dery, Jennifer Tremblay‐Mercier, Judes Poirier, Sylvia Villeneuve, Arthur F. Kramer, Maiya R. Geddes, PREVENT‐AD Research Group   +27 more
wiley   +1 more source

Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications

MedComm, Volume 6, Issue 12, December 2025.
Single‐cell sequencing has elucidated cell‐type‐specific transcriptional alterations, activated signaling pathways, metabolic reprogramming, immune infiltration, and chromatin‐associated genetic mechanisms in IPF, uncovering novel therapeutic targets.
Lin Zuo, Qiongliang Liu, Defeng Ye, Jiang Fan, Liang Wu   +4 more
wiley   +1 more source

Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway.

Brain Research
Formononetin has been demonstrated to protect against cerebral ischemia-reperfusion injury, however its mechanism has to be further researched. This study examined the effect of formononetin on cerebral ischemia-reperfusion injury in rats using the PARP ...
Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua Wu   +5 more
semanticscholar   +1 more source