Results 41 to 50 of about 5,113 (169)

Real‐World Effectiveness and Safety of Pegzilarginase Treatment in Arginase 1 Deficiency

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Pegzilarginase is the first disease‐modifying drug for arginase 1 deficiency. In clinical trials, pegzilarginase effectively normalised plasma arginine (pArg), which was associated with clinically relevant improvements in neuromotor outcomes. We report from a French early access scheme the first report on experience from pegzilarginase therapy
Anaïs Brassier, Alina Arion, Jean‐Baptiste Arnoux, Magalie Barth, Dries Dobbelaere, Magali Gorce, Michael Grövdal, Cécile Laroche, Olivia Rime, Manuel Schiff, Mattias Rudebeck   +10 more
wiley   +1 more source

Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase. [PDF]

, 2012
Poly(ADP-ribosyl)ation is a reversible post-translational protein modification involved in the regulation of a number of cellular processes including DNA repair, chromatin structure, mitosis, transcription, checkpoint activation, apoptosis and asexual ...
Knezevic, Claire, Brassington, Amy, Ahel, M, Dunstan, Mark S., Ahel, Marijan, Knezevic, CE, Ahel, I, Leys, D, Brassington, A, Lafite, P, Knezevic, Claire E., Barkauskaite, Eva, Hergenrother, Paul J., Dunstan, Mark, Hergenrother, PJ, Barkauskaite, E, Ahel, Ivan, Lafite, Pierre, Leys, David, Dunstan, MS, Hergenrother, Paul   +20 more
core   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

Inhibition of Poly (ADP-Ribose) Glycohydrolase Accelerates Osteoblast Differentiation in Preosteoblastic MC3T3-E1 Cells

, 2022
Poly ADP-ribosylation (PARylation) is a post-translational modification catalyzed by poly (ADP-ribose) polymerase (PARP) family proteins such as PARP1. Although PARylation regulates important biological phenomena such as DNA repair, chromatin regulation,
Mitsuko Masutani, Masutani, Mitsuko, Nozaki, Tadashige, Nakatsuka, Ryusuke, Ryusuke Nakatsuka, Sasaki, Yuka, Inouchi, Takuma, Yuka Sasaki, Takuma Inouchi, Tadashige Nozaki   +9 more
core   +1 more source

Insects and non‐woody plants slow down tropical forest succession: A community‐wide experiment in Papua New Guinea

Journal of Ecology, Volume 114, Issue 4, April 2026.
The importance of top‐down insect herbivory decreased, while the importance of bottom‐up plant competition with non‐woody plant species increased with elevation, representing a gradient of increasing environmental stress in the succession of woody plants.
Kari Sogera Iamba, Piotr Szefer, Kenneth Molem, Austin Sau, Gibson Maiah, Vojtech Novotny   +5 more
wiley   +1 more source

Intrinsic signaling pathways modulate targeted protein degradation

Nature Communications
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the anticancer target ...
Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, Jun Hamazaki, Shigeo Murata, Toshikazu Ushijima, Naoko Hattori, Fumiaki Ohtake   +14 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, Volume 20, Issue 3, Page 779-803, March 2026.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. [PDF]

, 2011
Post-translational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are critical for genome stability, including DNA repair, chromatin structure, mitosis and apoptosis.
Ahel, M, Slade, Dea, Ria Weston, Ahel, I, Neil Dixon, David Leys, Mark S. Dunstan, Dea Slade, Eva Barkauskaite, Dixon, N, Pierre Lafite, Dunstan, MS, Ahel, Marijan, Leys, D, Marijan Ahel, Lafite, P, Barkauskaite, Eva, Dunstan, Mark, Ivan Ahel, Weston, Ria, Barkauskaite, E, Weston, R, Ahel, Ivan, Lafite, Pierre, Leys, David, Slade, D, Dixon, Neil   +26 more
core   +1 more source

TSG101 Promotes SIAH1 Auto‐Ubiquitination to Drive Migration and Invasion in Hepatocellular Carcinoma Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Our previous studies have demonstrated that seven in absentia homologue 1 (SIAH1), an E3 ubiquitin ligase, is downregulated in hepatocellular carcinoma (HCC) and regulates substrate ubiquitination. However, the molecular mechanisms governing reduced SIAH1 expression in HCC remain unclear.
Jie Qiu, Xixi Gu, Kai Wu, Jinzhao Wu, Chenrui Xu, Wengang Shan, Hengliang Shi   +6 more
wiley   +1 more source

The Role of PARylation in Skeletal Muscle During the Development of Cancer Cachexia

, 2023
Cancer cachexia is a wasting syndrome causing involuntary weight loss and muscle atrophy. PARP1 is a nicotinamide dinucleotide-dependent enzyme that modifies target proteins by PARylation.
Nik-Akhtar, Abolfazl
core   +1 more source