Results 31 to 40 of about 5,113 (169)

Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase

Advances in Virology, 2019
Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans.
Liset Westera, Alisha M. Jennings, Jad Maamary, Martin Schwemmle, Adolfo García-Sastre, Eric Bortz   +5 more
doaj   +1 more source

Discovery and Structure–Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG) [PDF]

Journal of Medicinal Chemistry, 2011
The metabolism of poly(ADP-ribose) (PAR) in response to DNA strand breaks, which involves the concerted activities of poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolase (PARG), modulates cell recovery or cell death depending upon the level of DNA damage.
Jamin D, Steffen, Donna L, Coyle, Komath, Damodaran, Paul, Beroza, Myron K, Jacobson   +4 more
openaire   +2 more sources

Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase [PDF]

, 2017
Poly(ADP-ribosylation) of proteins following DNA damage is well studied and the use of poly(ADP-ribose) polymerase (PARP) inhibitors as therapeutic agents is an exciting prospect for the treatment of many cancers.
Bryant, Helen E., Kate M. Smith, James, D.I., Polly Gravells, Grant, E., Grant, Emma, James, Dominic I., Gravells, Polly, Smith, K.M., Gravells, P.L., Bryant, H.E., Helen E. Bryant, Smith, Kate M., Emma Grant, Dominic I. James   +14 more
core   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, EarlyView.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib

, 2016
The enzyme poly(ADP-ribose) glycohydrolase (PARG) performs a critical role in the repair of DNA single strand breaks (SSBs). However, a detailed understanding of its mechanism of action has been hampered by a lack of credible, cell-active chemical probes.
Donald J. Ogilvie, Fairweather, Emma, Donald J. Ogilvie (1920790), Waddell, Ian, Bohdan Waszkowycz, Alexandra I. J. Stowell, Jordan, Allan, Alison E. McGonagle, Nicola S. Hamilton (1920778), Allan M. Jordan, Stuart Jones, Hamilton, Nicola, Nicola S. Hamilton, Kate M. Smith (495084), Bohdan Waszkowycz (1920766), James, Dominic, Griffiths, Louise, Jones, Stuart, Stowell, Alexandra, James R. Hitchin (1920796), Kate M. Smith, Stuart Jones (2112958), Paul Kelly, Helen Small, Paul Kelly (95510), Ian D. Waddell, Alison E. McGonagle (1920781), Tucker, Julie, Ogilvie, Donald, Small, Helen, Colin P. Hutton, Louise A. Griffiths (3211443), Emma E. Fairweather (2084722), Alexandra I. J. Stowell (3211449), Dominic I. James (3211446), Emma E. Fairweather, Mcgonagle, Alison, Helen Small (3211437), James R. Hitchin, Hutton, Colin, Louise A. Griffiths, Smith, Kate, Hitchin, James, Julie Tucker (1846150), Ian D. Waddell (1920751), Julie Tucker, Waszkowycz, Bohdan, Kelly, Paul, Colin P. Hutton (3211440), Dominic I. James, Allan M. Jordan (1920763)   +50 more
core   +1 more source

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. [PDF]

, 2019
Inhibitors of poly(ADP-ribose) polymerase (PARP) have demonstrated efficacy in women with BRCA-mutant ovarian cancer. However, only 15%-20% of ovarian cancers harbor BRCA mutations, therefore additional therapies are required. Here, we show that a subset
Pillay, Nisha, James, Dominic, Bakker, Bjorn, Taylor, Stephen, Nelson, Louisa, Taylor, Stephen S, Littler, Samantha, James, Dominic I, Jackson, Dean A, Golder, Anya, Bakker, Bjorn; id_orcid, Tighe, Anthony, Morgan, Robert D.; id_orcid, Foijer, Floris; id_orcid, Foijer, Floris, Ogilvie, Donald, Spierings, Diana C J, Jordan, Allan, Smith, Kate M, Jackson, Dean, Morgan, Robert D, Bah, Nourdine, Jordan, Allan M, Smith, Kate, Coulson-Gilmer, Camilla, Ogilvie, Donald J   +25 more
core   +1 more source

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

The FEBS Journal, Volume 293, Issue 11, Page 3274-3287, June 2026.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar, Albert Galera‐Prat, Jin Cai, Julia Preisser, Tiila‐Riikka Kiema, Andreas Ladurner, Lari Lehtiö   +6 more
wiley   +1 more source

Replication Associated Base Excision Repair Regulates Replication Stress Induced PARP1/PARP2 Activation and Impacts PARP and PARG Inhibitor Resistance

, 2022
Endogenous and exogenous genotoxins pose a significant challenge to the DNA replication machinery, contributing to replication stress, a phenotype common in precancerous and cancerous cells but not common in normal cells.
Ibrahim, Md
core  

Inhibition of PARG activity in Trypanosoma cruzi.

, 2013
(A) Dot Blot analysis of poly(ADP-ribose) accumulation during epimastigote growth in cultures untreated (Control) or treated with 1 µM of the PARG inhibitor DEA (DEA) for four days.
Mariana Schlesinger (134331), Mirtha M. Flawiá (134341), Salomé C. Vilchez Larrea (134311), Guillermo D. Alonso (359836), María L. Kevorkian (420979), Silvia H. Fernández Villamil (134345)   +5 more
core   +1 more source