Results 11 to 20 of about 5,177 (98)

RSF1-Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites. [PDF]

Adv Sci (Weinh)
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Heo Y, Kim Y, Hwang N, Sung G, Jo S, Lee Y, Kang HC, Lee JH, Choi YW, Cho H, Min S.   +10 more
europepmc   +2 more sources

Hyperosmotic stress induces PARP1-mediated HPF1-dependent mono(ADP-ribosyl)ation. [PDF]

FEBS Lett
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Kopasz AG, Mérey M, Vásárhelyi R, Pék R, Imburchia V, Henn L, Kószó A, Lakin ND, Ahel I, Huet S, Czibula Á, Timinszky G.   +11 more
europepmc   +2 more sources

Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Cheng Z, Gao H, Wu W, Shi P, Chen X, Yu Z, Wu W, Zhao K, Yang C, Zhang Y.   +9 more
europepmc   +2 more sources

Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase. [PDF]

PLoS ONE, 2014
Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo.
Zhizhi Wang, Jean-Philippe Gagné, Guy G Poirier, Wenqing Xu   +3 more
doaj   +1 more source

Poly(ADP-ribosylation) is present in murine sciatic nerve fibers and is altered in a Charcot-Marie-Tooth-1E neurodegenerative model [PDF]

PeerJ, 2017
Background Poly-ADP-ribose (PAR) is a polymer synthesized by poly-ADP-ribose polymerases (PARPs) as a postranslational protein modification and catabolized mainly by poly-ADP-ribose glycohydrolase (PARG).
Laura I. Lafon Hughes, Carlos J. Romeo Cardeillac, Karina B. Cal Castillo, Salomé C. Vilchez Larrea, José R. Sotelo Sosa, Gustavo A. Folle Ungo, Silvia H. Fernández Villamil, Alejandra E. Kun González   +7 more
doaj   +2 more sources

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

Journal of Experimental & Clinical Cancer Research, 2021
Background Patients with ovarian cancer often present at advanced stage and, following initial treatment success, develop recurrent drug-resistant disease. PARP inhibitors (PARPi) are yielding unprecedented survival benefits for women with BRCA-deficient
Camilla Coulson-Gilmer, Robert D. Morgan, Louisa Nelson, Bethany M. Barnes, Anthony Tighe, René Wardenaar, Diana C. J. Spierings, Helene Schlecht, George J. Burghel, Floris Foijer, Sudha Desai, Joanne C. McGrail, Stephen S. Taylor   +12 more
doaj   +1 more source

PARG Inhibition Modulates Viability, Clonogenicity and Migration of Breast Cancer Cells Response to Radiotherapy [PDF]

Zagazig University Medical Journal
Background Targeting DNA repair through inhibition of poly (ADP-ribose) glycohydrolase (PARG) enzyme is a promising strategy to modulate cancer resistance to traditional therapy.
Nadia Abd El Moneim, Fawziya Ibrahim, Nermin Bekheet, Shaymaa E. El Feky, Medhat Haroun, Marwa Essawy, Mohammed Salama   +6 more
doaj   +1 more source

Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

Neoplasia: An International Journal for Oncology Research
The ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown.
Rocco Caggiano, Evgeniia Prokhorova, Lena Duma, Kira Schützenhofer, Raffaella Lauro, Giuliana Catara, Rosa Marina Melillo, Angela Celetti, Rebecca Smith, S John Weroha, Scott H Kaufmann, Ivan Ahel, Luca Palazzo   +12 more
doaj   +1 more source

In Vivo Level of Poly(ADP-ribose)

Challenges, 2018
PolyADP-ribosylation is a post-translational modification that plays key roles in cellular physiological functions and DNA damage responses. PolyADP-ribosylation is finely and dynamically regulated by various enzymes and factors involved in the synthesis
Masanao Miwa, Chieri Ida, Sachiko Yamashita, Kenichi Kouyama, Yasuhito Kuroda, Takayuki Eguchi, Narumi Ohta, Teruaki Sato, Masataka Tsuda, Masakazu Tanaka   +9 more
doaj   +1 more source

Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer

Journal for ImmunoTherapy of Cancer
Background Ovarian cancer is the most lethal gynecological malignancy, with limited treatment options after failure of standard therapies. Despite the potential of poly(ADP-ribose) polymerase inhibitors in treating DNA damage response (DDR)-deficient ...
Lorna Rodriguez-Rodriguez, Rui Huang, Mihaela Cristea, Qianqian Zhao, Adrian Kohut, Hua Yu, Mihae Song, Antons Martincuks, Chunyan Zhang, Edward W Wang, Theresa Austria, Yi-Jia Li, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Binghui Shen   +14 more
doaj   +1 more source