Results 21 to 30 of about 3,357,233 (168)

Poly(ADP-ribosylation) is present in murine sciatic nerve fibers and is altered in a Charcot-Marie-Tooth-1E neurodegenerative model [PDF]

PeerJ, 2017
Background Poly-ADP-ribose (PAR) is a polymer synthesized by poly-ADP-ribose polymerases (PARPs) as a postranslational protein modification and catabolized mainly by poly-ADP-ribose glycohydrolase (PARG).
Laura I. Lafon Hughes, Carlos J. Romeo Cardeillac, Karina B. Cal Castillo, Salomé C. Vilchez Larrea, José R. Sotelo Sosa, Gustavo A. Folle Ungo, Silvia H. Fernández Villamil, Alejandra E. Kun González   +7 more
doaj   +2 more sources

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

Journal of Experimental & Clinical Cancer Research, 2021
Background Patients with ovarian cancer often present at advanced stage and, following initial treatment success, develop recurrent drug-resistant disease. PARP inhibitors (PARPi) are yielding unprecedented survival benefits for women with BRCA-deficient
Camilla Coulson-Gilmer, Robert D. Morgan, Louisa Nelson, Bethany M. Barnes, Anthony Tighe, René Wardenaar, Diana C. J. Spierings, Helene Schlecht, George J. Burghel, Floris Foijer, Sudha Desai, Joanne C. McGrail, Stephen S. Taylor   +12 more
doaj   +1 more source

Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

Neoplasia: An International Journal for Oncology Research
The ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown.
Rocco Caggiano, Evgeniia Prokhorova, Lena Duma, Kira Schützenhofer, Raffaella Lauro, Giuliana Catara, Rosa Marina Melillo, Angela Celetti, Rebecca Smith, S John Weroha, Scott H Kaufmann, Ivan Ahel, Luca Palazzo   +12 more
doaj   +1 more source

In Vivo Level of Poly(ADP-ribose)

Challenges, 2018
PolyADP-ribosylation is a post-translational modification that plays key roles in cellular physiological functions and DNA damage responses. PolyADP-ribosylation is finely and dynamically regulated by various enzymes and factors involved in the synthesis
Masanao Miwa, Chieri Ida, Sachiko Yamashita, Kenichi Kouyama, Yasuhito Kuroda, Takayuki Eguchi, Narumi Ohta, Teruaki Sato, Masataka Tsuda, Masakazu Tanaka   +9 more
doaj   +1 more source

PARP and PARG Inhibitors—New Therapeutic Targets in Cancer Treatment

Pathology & Oncology Research, 2010
Today, the number of cancer patients throughout the world is increasing alarmingly and as per the World Health Organisation (WHO) data and statistics the prediction for the year 2020 will be 15 million new cases as compared to only 10 million cases in year 2000 leaving us dumbfounded.
Nilufer Jasmine Selimah, Fauzee, Juan, Pan, Ya-lan, Wang   +2 more
openaire   +2 more sources

DePARylation is critical for S phase progression and cell survival

eLife
Poly(ADP-ribose)ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation by poly(ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic regulation of DNA damage response.
Litong Nie, Chao Wang, Min Huang, Xiaoguang Liu, Xu Feng, Mengfan Tang, Siting Li, Qinglei Hang, Hongqi Teng, Xi Shen, Li Ma, Boyi Gan, Junjie Chen   +12 more
doaj   +1 more source

Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase

Advances in Virology, 2019
Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans.
Liset Westera, Alisha M. Jennings, Jad Maamary, Martin Schwemmle, Adolfo García-Sastre, Eric Bortz   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, EarlyView.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

ROS‐ATM‐CBP axis‐mediated PARP1 lactylation aggravates doxorubicin‐induced cardiotoxicity

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ROS function as signalling molecules to promote CBP‐mediated PARP1 lactylation in an ATM dependent manner, which induces PARP1 PARylation and ultimate cell apoptosis. CBP and SIRT1 as specific lactyltransferase and delactylase of PARP1. Lactylation of PARP1 depends on the LDHA activity and lactate production.
Wenbin Wang, Yingxian Sun
wiley   +1 more source