Results 51 to 60 of about 3,357,233 (168)

PARG activity is required for cell death by parthanatos

bioRxiv
Cell death by a non-apoptotic pathway termed parthanatos is induced by hyperactivation of the DNA damage sensor PARP1, which uses NAD+ as a substrate to catalyse the poly-ADP-ribosylation (PARylation) of proteins.
Rafael Dias de Moura, Beatriz Kopel, Priscilla Doria de Mattos, Penélope Ferreira Valente, Aline Costa Santos, Rafael Teixeira do Nascimento, F. M. Prado, Marisa H G Medeiros, J. Setubal, N. C. de Souza Pinto, N. Hoch   +10 more
semanticscholar   +1 more source

PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse.

EMBO Reports
Poly(ADP-ribosyl)ation (PARylation) is a transient post-translational modification catalyzed by PARP enzymes and reversed by PARG. PARG inhibition causes sustained PARylation and is being explored as an anticancer strategy, but its cellular consequences ...
Alexandra Mihuț, Debanjan Ghosh, Adrián Kószó, Dávid Szüts, S. Salajkova, Martin Andrs, Jana Dobrovolna, Roberta Fajka-Boja, Gyula Timinszky   +8 more
semanticscholar   +1 more source

Effect of putative PARG inhibitors identified by an in silico approach on Trypanosoma cruzi infection

, 2019
Fil: Fernandez Villamil, Silvia Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N.
Svagzdys, Ailin, Vilchez Larrea, Salomé Catalina, Alberca, Lucas Nicolás, Caram, Franco, Talevi, Alan, Fernandez Villamil, Silvia Hebe   +5 more
openaire   +1 more source

PARG inhibition in ATM-deficient prostate cancer: from mechanistic discovery to therapeutic potential. [PDF]

J Transl Med
Zhou X, Guo C, Fan Z, Lou Y, Yue Z, Xu W, Xin Z, Ren S.   +7 more
europepmc   +1 more source

CHD1L maintains genome integrity by facilitating okazaki fragment maturation. [PDF]

Nucleic Acids Res
Nie L, Fu J, Huang M, Zhang H, Ma T, Yang C, Li S, Wang C, Chen J.   +8 more
europepmc   +1 more source

Targeting MARylation and DePARylation in Cancer Therapy: New Promising Therapeutic Opportunities. [PDF]

Cancers (Basel)
Cabeza-Fernández V, Ríos-Sola FJ, Martín-Oliva D, Borrego-Pérez J, Oliver FJ, YéLamos J, Rodríguez-Vargas JM.   +6 more
europepmc   +1 more source

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling. [PDF]

Nat Commun
Dauben H, Mihaljević M, Kolvenbach A, Palumbieri MD, Kapsali C, Huppertz I, Matić I.   +6 more
europepmc   +1 more source

The Expanding Landscape of ADP-Ribosylation: Protein, DNA, RNA, and Mitochondrial Regulation. [PDF]

Chem Res Toxicol
Sin YC, Zhao L.
europepmc   +1 more source

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Cancer Cell, 2019
E. Gogola, A. Duarte, J. D. de Ruiter, W. Wiegant, Jonas A. Schmid, Roebi de Bruijn, D. James, Sergi Guerrero Llobet, D. Vis, S. Annunziato, Bram van den Broek, M. Barazas, A. Kersbergen, M. van de Ven, M. Tarsounas, D. Ogilvie, M. V. van Vugt, L. Wessels, J. Bártková, I. Gromova, Miguel Andújar-Sánchez, J. Bartek, Massimo Lopes, Haico van Attikum, P. Borst, J. Jonkers, S. Rottenberg   +26 more
semanticscholar   +1 more source

PARP-2 catalytic activity drives replication-ICL repair in an allele-specific manner during germline development. [PDF]

PLoS Genet
Ren X, Hu A, Liu Z, Kim S, Kim HM.
europepmc   +1 more source