Results 51 to 60 of about 5,113 (169)

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Programmable Hydrogels: Frontiers in Dynamic Closed‐Loop Systems, Biomimetic Synergy, and Clinical Translation

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang, Bohan Yin, Behzad Shiroud Heidari, George Youssef, Monika Gosecka, Mateusz Gosecki, Fernando G. Torres, Siu Hong Dexter Wong, Jagan Mohan Dodda   +8 more
wiley   +1 more source

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease Prokhorova et al.

, 2021
ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear. ARH3 is the only hydrolase able to remove serine-linked mono(ADP-ribose) (MAR) but is much less efficient than PARG ...
Ahel, I (via Mendeley Data)
core   +1 more source

Attitudes to aging are associated with cognition and biomarker status in older adults at risk for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S4, December 2025.
Abstract Background Attitudes toward aging influence longevity as well as physical and psychological health, yet their relationship with cognition and Alzheimer's disease (AD) remains largely unknown. We hypothesized that positive attitudes toward aging would predict better cognition and diminished risk on AD blood‐based biomarker profiles in older ...
Franciska Otaner, Caitlin S. Walker, Adrián Noriega de la Colina, Linda Li, Carolynn Boulanger, Nagashree Thovinakere, Alix Noly‐Gandon, Garance Barnoin, Mitchell Bennett, Jillian Caplan, Laurence Côté, Sarah Elbaz, Shania Fock Ka Bao, Ryan Kara, Nicolas Lavoie, Maggie Nguyen, Helen Pallett‐Wiesel, Johanie Victoria Piché, Andreanne Powers, Sofia Ricciardelli, Kayla Williams, Christine Dery, Jennifer Tremblay‐Mercier, Judes Poirier, Sylvia Villeneuve, Arthur F. Kramer, Maiya R. Geddes, PREVENT‐AD Research Group   +27 more
wiley   +1 more source

PO-496 Loss of PARG drives PARP inhibitor resistance in BRCA2-deficient mouse mammary tumours

ESMO Open, 2018
ABSTRACT Introduction Inhibitors of poly(ADP-ribose) polymerase (PARP) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, resistance to PARP inhibitors (PARPi) is a clinical hurdle, and we poorly understand how cancer cells escape the deadly effects of PARPi ...
E. Gogola, J. Jonkers, S. Rottenberg
openaire   +1 more source

Identifying and overcoming mechanisms of PARP 2 inhibitor resistance in homologous recombination 3 repair-deficient and repair-proficient high grade 4 serous ovarian cancer cells [PDF]

, 2020
High grade serous ovarian cancer (HGSOC) is a major cause of female cancer mortality. The approval of poly (ADP-ribose) polymerase (PARP) inhibitors for clinical use has greatly improved treatment options for patients with homologous recombination repair
David W. Melton, Churchman, Michael, Mark J. O’Connor, Leo, Elisabetta, Hollis, Robb; id_orcid, Robert L. Hollis, Colomer, Carlota, Melton, David, Miriam K. Gomez, Elisabetta Leo, J. O'Connor, Mark, Illuzzi, Giuditta, Giuditta Illuzzi, Michael Churchman, Carlota Colomer, Gomez, Miriam, Gourley, Charlie, Charlie Gourley   +17 more
core   +1 more source

Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications

MedComm, Volume 6, Issue 12, December 2025.
Single‐cell sequencing has elucidated cell‐type‐specific transcriptional alterations, activated signaling pathways, metabolic reprogramming, immune infiltration, and chromatin‐associated genetic mechanisms in IPF, uncovering novel therapeutic targets.
Lin Zuo, Qiongliang Liu, Defeng Ye, Jiang Fan, Liang Wu   +4 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Barriers and opportunities for consumption of invasive lionfish in Belize

People and Nature, Volume 7, Issue 11, Page 2777-2793, November 2025.
Abstract Invasive lionfish (Pterois spp.) have rapidly spread across the Western Atlantic and Mediterranean Sea. They reproduce frequently and consume native marine life important to livelihoods and reef health. To combat the deleterious impacts of this species, management efforts in Belize and throughout the invaded range have included development of ...
Kaylin R. Clements, Julie Sabattis, Jennifer K. Chapman, Phil P. Krening, Marc L. Fruitema, Kelly D. Martin, Jennifer N. Solomon   +6 more
wiley   +1 more source