Results 71 to 80 of about 6,510 (175)
, 2023 <p>HuR regulates all isoforms of PARG by binding a discrete minimal binding region (MBR) within its 3'UTR in both DDR- proficient MIA PaCa-2 and DDR- deficient Hs 766t cells. Such PARG mRNA and protein expression is also increased with other non-PARPi stress such as gemcitabine and oxaliplatin treatment, which simultaneously induce HuR ...
Jonathan R. Brody +17 more
openaire +1 more source
Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]
, 2011 Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
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Advanced Science, Volume 12, Issue 39, October 20, 2025.This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue +6 more
wiley +1 more source
The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death [PDF]
, 2018 .: Poly(ADP-ribose) (PAR) has been identified as a DNA damage-inducible cell death signal upstream of apoptosis-inducing factor (AIF). PAR causes the translocation of AIF from mitochondria to the nucleus and triggers cell death.
Althaus, F. +3 more
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Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function. [PDF]
, 2015 Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation ...
de Bono, Johann S. +3 more
core +2 more sources
The PREVENT‐AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT‐AD) is an investigator‐driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median ...
Sylvia Villeneuve +44 more
wiley +1 more source
Poly(ADP-ribose) Polymerase-1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Potential [PDF]
, 2014 Poly(ADP-ribosyl)ation reactions, carried out by poly(ADP-ribose) polymerases (PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous cellular processes (e.g., DNA repair, transcription, metabolism, or immune functions). PARP1
Bay, Péter, Little, P., Liu, P., Xu, S.
core +1 more source
, 2023 <p>HuR directly binds and regulates poly-ADP ribose glycohydrolase mRNA expression particularly under PARPi stress, but doesn't affect expression of other PAR polymerases or hydrolyzing enzymes.</p>
Jonathan R. Brody +17 more
openaire +1 more source
Family-wide analysis of poly(ADP-ribose) polymerase activity [PDF]
, 2014 The poly(adenosine diphosphate (ADP)-ribose) polymerase (PARP) protein family generates ADP-ribose (ADPr) modifications onto target proteins using NAD[superscript +] as substrate.
Ahel, Ivan +7 more
core +1 more source
Proximity in chromatin : opportunities for innovations [PDF]
, 2014 Mammalian chromosomes extensively communicate with each other via long-range chromatin interactions. These interactions are mostly mediated by proteins, which work as teams to control genes in the cells.
Yammine, Samer
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