Results 71 to 80 of about 5,113 (169)

Poly (ADP-ribose) glycohydrolase (PARG) is a new therapeutic target for breast cancer

, 2013
Breast cancer is a heterogeneous disease, but is invariably associated with genome wide deregulation of transcription. The silencing of tumor suppressor genes (TSGs) in particular is thought to be an early, initiating event in many cancers.
Lovato, Amanda
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Supplementary Data from Dysfunction of Poly (ADP-Ribose) Glycohydrolase Induces a Synthetic Lethal Effect in Dual Specificity Phosphatase 22-Deficient Lung Cancer Cells

, 2019
Figure S2 shows that cell growth inhibition by knockdown of both DUSP22 and PARG was recovered by the treatment with p38 MAPK inhibitor.
Mitsuko Masutani (78971), Kazuto Ashizawa (793660), Miyuki Hozumi (14936060), Kengo Inoue (5933036), Takae Onodera (14936063), Yuka Sasaki (140958), Hiroaki Fujimori (209966), Tadashige Nozaki (78965), Fumiaki Koizumi (515980), Yasufumi Murakami (78968)   +9 more
core   +1 more source

Effect of PARG inhibitors on T. cruzi infection on Vero or A549 host cells.

, 2013
T. cruzi trypomastigotes were purified from the supernatant of previously infected cells and preincubated for 30 min in the respective culture medium in the absence (Control) or presence of 1 µM PARG inhibitor (DEA).
Mariana Schlesinger (134331), Mirtha M. Flawiá (134341), Salomé C. Vilchez Larrea (134311), Guillermo D. Alonso (359836), María L. Kevorkian (420979), Silvia H. Fernández Villamil (134345)   +5 more
core   +1 more source

The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death

, 2011
The emergence of resistance to cancer treatments through methods that generate cell death by inducing DNA damage, such as chemotherapeutics and radiation therapy, is a major obstacle to overcoming the disease.
Finch, Kristin E.
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Effect of putative PARG inhibitors identified by an in silico approach on Trypanosoma cruzi infection

, 2019
Fil: Fernandez Villamil, Silvia Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N.
Svagzdys, Ailin, Vilchez Larrea, Salomé Catalina, Alberca, Lucas Nicolás, Caram, Franco, Talevi, Alan, Fernandez Villamil, Silvia Hebe   +5 more
openaire   +1 more source

Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention : assessment of currently available pharmacological tools

, 2004
Poly(ADP-ribose) glycohydrolase (PARG) is being considered as a therapeutic target for the prevention of neurodegeneration. Here, we assessed the pharmacological tools available for target validation. The tannic acid derivative gallotannin inhibited PARG
Falsig, Jeppe, Li Oei, Shiao, Feuerhahn, Sascha, Leist, Marcel, Keil, Claudia, Hofman Christiansen, Søren, Bürkle, Alexander   +6 more
core   +1 more source

DUAL ROLE FOR POLY(ADP-RIBOSE)POLYMERASE-1 AND -2 AND POLY(ADP-RIBOSE)GLYCOHYDROLASE AS DNA-REPAIR AND PRO-APOPTOTIC FACTORS IN RAT GERMINAL CELLS EXPOSED TO NITRIC OXIDE DONORS.

, 2004
We describe the involvement of poly(ADP-ribose)polymerase 1 and 2 (PARP-1 and -2) and poly(ADP-ribose)glycohydrolase (PARG) in the response of rat germinal cells to the action of the NO donors, 3-morpholino-sydnonimine (SIN-1) and spermine nonoate (SNO).
QUESADA, PIERINA MARIA
core   +2 more sources

Analysis of PARylation and PTEN Mutation Effects on PARP and PARG Inhibition Treatment in Primary Brain Tumors

, 2019
: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, with a median survival of approximately 15 months. Standard care for GBM has remained the same for more than 10 years and has yet to produce remission.
Hermanowski, Henre Michael
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PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models

, 2014
International audienceBackground: Hepatocellular carcinoma is the third cause of cancer related death for which new treatment strategies are needed. Targeting DNA repair pathways to sensitize tumor cells to chemo-or radiotherapy is under investigation ...
Sagne, Charlotte, Sauvaigo, Sylvie, Guillot, Clément, Merle, Philippe, Favaudon, Vincent, Chemin, Isabelle, Hall, Janet, Herceg, Zdenko   +7 more
core   +1 more source

Design, Development, and Evaluation of Tools to Study Cellular ADP-ribose Polymer Metabolism

, 2011
The metabolism of ADP-ribose polymers (PAR) is involved in several cellular processes with a primary focus on maintaining genomic integrity. PAR metabolism following genotoxic stress is transient due to a close coordination between poly(ADP-ribose ...
Steffen, Jamin D.
core