Results 81 to 90 of about 9,423,446 (404)

Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's [PDF]

, 2019
Background: Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the
Brown, R. G., Chaudhuri, K. R., Hurt, C. S., Moss-Morris, R., Rixon, L., Samuel, M.   +5 more
core   +3 more sources

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease

Nature Genetics, 2014
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and
M. Nalls, N. Pankratz, C. Lill, Chuong B. Do, D. Hernandez, D. Hernandez, M. Saad, M. Saad, M. Saad, A. Destefano, A. Destefano, E. Kara, J. Bras, M. Sharma, C. Schulte, Margaux F. Keller, S. Arepalli, Christopher T Letson, Connor Edsall, H. Stefánsson, Xinmin Liu, Hannah A. Pliner, Joseph H. Lee, R. Cheng, M. Ikram, J. Ioannidis, G. Hadjigeorgiou, J. Bis, Miguel Ángel Martínez, Miguel Ángel Martínez, J. Perlmutter, A. Goate, K. Marder, B. Fiske, Margaret Sutherland, G. Xiromerisiou, R. Myers, L. Clark, K. Stefánsson, J. Hardy, P. Heutink, Honglei Chen, N. Wood, H. Houlden, H. Payami, A. Brice, A. Brice, W. Scott, T. Gasser, L. Bertram, N. Eriksson, T. Foroud, A. Singleton   +52 more
semanticscholar   +1 more source

CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Iñigo Ruíz‐Barrio, Javier Pagonabarraga, Anna Vázquez‐Oliver, Andrea Horta‐Barba, Jaime Kulisevsky, Saül Martínez‐Horta   +7 more
wiley   +1 more source

Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases [PDF]

, 2017
Objective: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients.
,, Bajaj, Nin, Barker, Roger A., Ben-Shlomo, Yoav, Burn, David J., Foltynie, Tom, Grosset, Donald G., Grosset, Katherine A., Hardy, John, Lawton, Michael A., Malek, Naveed, Morris, Huw R., Williams, Nigel M., Wood, Nicholas   +13 more
core   +5 more sources

Coffee Consumption Is Associated With Later Age‐at‐Onset of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Observation studies suggest that coffee consumption may lower the risk and delay the age‐at‐onset (AAO) of Parkinson's disease (PD). The aim of this study was to explore the causal relationship and genetic association between coffee consumption and the AAO, risk, and progression of PD. Using Mendelian randomization, we identified a significant
Dariia Kuzovenkova, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +3 more
wiley   +1 more source

Parkinson's Disease and Parkinsonism: Neuropathology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable associated extrapyramidal signs and symptoms, is accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal loss and reactive gliosis in the substantia nigra found at autopsy.
openaire   +3 more sources

Palliative care and Parkinson's disease : meeting summary and recommendations for clinical research [PDF]

, 2017
Introduction: Palliative care is an approach to caring for patients and families affected by serious illnesses that focuses on the relief of suffering through the management of medical symptoms, psychosocial issues, advance care planning and spiritual ...
Bekelman, David, Carter, Julie, Carter, Julie H., Fox, Siobhán, Galifianakis, Nicholas, Galifianakis, Nicholas B., Johnson, Miriam, Johnson, Miriam J., Katz, Maya, Kluger, Benzi, Kluger, Benzi M., Kutner, Jean, Kutner, Jean S., Miyasaki, Janis, Richfield, Edward, Richfield, Edward W., Subramanian, Indu, Timmons, Suzanne   +17 more
core   +1 more source

Precision‐Optimised Post‐Stroke Prognoses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error metrics across samples of patients whose outcomes are known.
Thomas M. H. Hope, Howard Bowman, Rachel M. Bruce, Alex P. Leff, Cathy J. Price   +4 more
wiley   +1 more source

Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring

Neurobiology of Disease, 2022
Background: Motor symptoms of Parkinson's disease (PD) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated.
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin   +10 more
doaj  

Goal-orientated cognitive rehabilitation for dementias associated with Parkinson's disease―A pilot randomised controlled trial [PDF]

, 2018
OBJECTIVE: To examine the appropriateness and feasibility of cognitive rehabilitation for people with dementias associated with Parkinson's in a pilot randomised controlled study.
Brand, Andrew, Clare, Linda, Hindle, John V., Hoare, Zoe, Martyr, Anthony, Roberts, Julie, Watermeyer, Tamlyn   +6 more
core   +4 more sources