Results 81 to 90 of about 196,808 (340)

Cerebello‐Prefrontal Connectivity Underlying Cognitive Dysfunction in Spinocerebellar Ataxia Type 2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 2 (SCA2) is a hereditary cerebellar degenerative disorder, with motor and cognitive symptoms. The constellation of cognitive symptoms due to cerebellar degeneration is named cerebellar cognitive affective syndrome (CCAS), which has increasingly been recognized to profoundly impact patients' quality of life;
Ami Kumar, Ruo‐Yah Lai, Zena Fadel, Yicheng Lin, Pia Parekh, Rachel Griep, Ming‐Kai Pan, Sheng‐Han Kuo   +7 more
wiley   +1 more source

A hierarchical coding-window model of Parkinson's disease [PDF]

arXiv, 2013
Parkinson's disease is an ongoing challenge to theoretical neuroscience and to medical treatment. During the evolution of the disease, neurodegeneration leads to physiological and anatomical changes that affect the neuronal discharge of the Basal Ganglia to an extent that impairs normal behavioral patterns.
arxiv  

Parkinson Disease [PDF]

Clinics in Geriatric Medicine, 2020
Carlos, Singer, Stephen G, Reich
openaire   +3 more sources

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan, Huaju Tian, Cheng Wu, Yue Zhao, Daiying Zhang, Yujie Zheng, Yuan Li, Xiaoxia Duan   +7 more
wiley   +1 more source

Determining the severity of Parkinson's disease in patients using a multi task neural network [PDF]

Multimedia Tools and Applications, Volume 83, pages 6077-6092, 2024
Parkinson's disease is easy to diagnose when it is advanced, but it is very difficult to diagnose in its early stages. Early diagnosis is essential to be able to treat the symptoms. It impacts on daily activities and reduces the quality of life of both the patients and their families and it is also the second most prevalent neurodegenerative disorder ...
arxiv   +1 more source

Home‐Based Tele‐tDCS in Amyotrophic Lateral Sclerosis: Feasibility, Safety, and Preliminary Efficacy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options. Transcranial direct current stimulation (tDCS) shows promise as a neuromodulatory intervention in various neurological disorders, but its application in ALS, particularly in a remote, home‐based format, remains underexplored.
Sangeetha Madhavan, Shravni Deshmukh, Mark Cummings, Aditi Doshi, Kourosh Rezania, Sally Freels, Gina Sawa   +6 more
wiley   +1 more source

Time series analysis of Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis [PDF]

arXiv, 2013
The aim of this paper is to study the (clinical) time-series data of three diseases with complex dynamics: Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis. For this purpose, first all of the time series data are embedded in a vector space of suitable dimension and then the correlation dimension of the above mentioned ...
arxiv  

An Explainable Machine Learning Model for Early Detection of Parkinson's Disease using LIME on DaTscan Imagery [PDF]

arXiv, 2020
Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose a machine learning model that accurately classifies any given DaTscan as having Parkinson's disease or not, in ...
arxiv  

Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (STN) activity in various dystonia types is critical to provide a comprehensive understanding of dystonia ...
Zhu Guan‐Yu, Yin Zi‐Xiao, Chen Ying‐Chuan, Timon Merk, Thomas Binns, Ma Ruo‐Yu, Du Ting‐Ting, Liu Yu‐Ye, Xie Hu‐Tao, Shi Lin, Yang An‐Chao, Meng Fan‐Gang, Wolf‐Julian Neumann, Andrea A. Kühn, Zhang Jian‐Guo   +14 more
wiley   +1 more source

Thalamic Deep Brain Stimulation for Orthostatic Tremor

Tremor and Other Hyperkinetic Movements, 2011
Background: Orthostatic tremor is an uncommon disorder manifest by high frequency, low amplitude leg tremor upon weight bearing. Treatment with oral tremor agents is inconsistent and usually not satisfactory.
Toby C. Yaltho, William G. Ondo
doaj   +1 more source