Results 1 to 10 of about 9,618,511 (343)

Image-guided programming deep brain stimulation improves clinical outcomes in patients with Parkinson’s disease

npj Parkinson's Disease
Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). However, some patients may not respond optimally to clinical programming adjustments.
Viviana Torres, Kirsys Del Giudice, Pedro Roldán, Jordi Rumià, Esteban Muñoz, Ana Cámara, Yaroslau Compta, Almudena Sánchez-Gómez, Francesc Valldeoriola   +8 more
doaj   +1 more source

Cavitation Feedback Control of Focused Ultrasound Blood-Brain Barrier Opening for Drug Delivery in Patients with Parkinson’s Disease [PDF]

, 2022
Yuexi Huang, Ying Meng, Christopher B. Pople, Allison Bethune, Ryan M. Jones, Agessandro Abrahão, Clement Hamani, Suneil K. Kalia, Lorraine V. Kalia, Nir Lipsman, Kullervo Hynynen   +10 more
openalex   +1 more source

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity

Brain Sciences, 2017
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Ryoma Morigaki, Satoshi Goto
doaj   +1 more source

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Nature Communications, 2020
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber   +8 more
doaj   +1 more source

Additional file 2: of LRRK2 contributes to monocyte dysregulation in Parkinsonâ s disease

, 2019
LRRK2 protein expression is significantly upregulated in monocytes from PD patients. (PDF 303 kb)
Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang, Brenner, David, Melrose, Heather, Bauer, Peter, Ludolph, Albert, Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen, Danzer, Karin   +11 more
openaire   +1 more source

Effect of dopamine on limbic network connectivity at rest in Parkinson’s disease patients with freezing of gait

Translational Neuroscience
Freezing of gait (FOG) in Parkinson’s disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the ...
Quek Dione Y. L., Taylor Natasha, Gilat Moran, Lewis Simon J. G., Ehgoetz Martens Kaylena A.   +4 more
doaj   +1 more source

Asymmetric Dopaminergic Degeneration and Attentional Resources in Parkinson’s Disease

Frontiers in Neuroscience, 2018
Background: Attention is crucial to voluntary perform actions in Parkinson’s disease (PD), allowing patients to bypass the impaired habitual motor control.
Paola Ortelli, Davide Ferrazzoli, Marianna Zarucchi, Roberto Maestri, Giuseppe Frazzitta   +4 more
doaj   +1 more source

Additional file 10: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients

, 2015
List of common genes between A9 DA neurons of the SN in the mouse and differentially expressed transcripts in the blood of PD patients according to SAM (a) and PUMA (b). (PDF 3122 kb)
Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego Di, Pizzolato, Gilberto, Gustincich, Stefano   +17 more
openaire   +1 more source

Additional file 3: of Blood transcriptomics of drug-naĂŻve sporadic Parkinsonâ s disease patients

, 2015
List of the 395 variables selected by Ranking-PCA to discriminate between PD patients and controls. Order of variables, Affymetrix Probe Set IDs, gene symbols and names are indicated. (PDF 3122 kb)
Calligaris, Raffaella, Banica, Mihaela, Roncaglia, Paola, Robotti, Elisa, Finaurini, Sara, Vlachouli, Christina, Antonutti, Lucia, Iorio, Francesco, Carissimo, Annamaria, Cattaruzza, Tatiana, Ceiner, Andrea, Lazarevic, Dejan, Cucca, Alberto, Pangher, Nicola, Marengo, Emilio, Bernardo, Diego Di, Pizzolato, Gilberto, Gustincich, Stefano   +17 more
openaire   +1 more source

Additional file 1: of Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinsonâ s disease: what is the impact of Parkinsonâ s disease on surgical outcome?

, 2019
The assessment Scale Proposed by the Japanese Orthopaedic Association. The Japanese Orthopaedic Association Scoring system (JOA score) consists of 2 categories (subjective and objective symptoms), ranging from 0 (worst condition) to 15 (best condition). (DOCX 22 kb)
Watanabe, Kei, Katsumi, Keiichi, Ohashi, Masayuki, Shibuya, Yohei, Izumi, Tomohiro, Hirano, Toru, Endo, Naoto, Kaito, Takashi, Yamashita, Tomoya, Fujiwara, Hiroyasu, Yukitaka Nagamoto, Matsuoka, Yuji, Suzuki, Hidekazu, Hirosuke Nishimura, Hidetomi Terai, Tamai, Koji, Tagami, Atsushi, Syuta Yamada, Adachi, Shinji, Toshitaka Yoshii, Shuta Ushio, Harimaya, Katsumi, Kawaguchi, Kenichi, Yokoyama, Nobuhiko, Oishi, Hidekazu, Doi, Toshiro, Kimura, Atsushi, Inoue, Hirokazu, Inoue, , Miyagi, Masayuki, Saito, Wataru, Nakano, Atsushi, Sakai, Daisuke, Nukaga, Tadashi, Ikegami, Shota, Shimizu, Masayuki, Futatsugi, Toshimasa, Ohtori, Seiji, Furuya, Takeo, Sumihisa Orita, Imagama, Shiro, Ando, Kei, Kobayashi, Kazuyoshi, Kiyasu, Katsuhito, Murakami, Hideki, Yoshioka, Katsuhito, Seki, Shoji, Hongo, Michio, Kakutani, Kenichiro, Yurube, Takashi, Yasuchika Aoki, Oshima, Masashi, Takahata, Masahiko, Iwata, Akira, Hirooki Endo, Abe, Tetsuya, Tsukanishi, Toshinori, Nakanishi, Kazuyoshi, Watanabe, Kota, Hikata, Tomohiro, Suzuki, Satoshi, Isogai, Norihiro, Eijiro Okada, Funao, Haruki, Ueda, Seiji, Shiono, Yuta, Nojiri, Kenya, Naobumi Hosogane, Ishii, Ken   +68 more
openaire   +1 more source