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, 1998 Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson’s disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition.
Maria Grazia Spillantini +4 more
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The Four Square Step Test for Assessing Cognitively Demanding Dynamic Balance in Parkinson’s Disease Patients [PDF]
Journal of Movement Disorders, 2021 Objective The Four Square Step Test (FSST) is a tool that assesses dynamic balance during obstacle step-over. To date, few studies have used the FSST to measure balance in patients with Parkinson’s disease (PD).
Jinhee Kim +3 more
doaj +1 more source
Translational Neurodegeneration, 2022 Background Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degeneration in PD models.
Yi-Qing Lv +7 more
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A novel automated morphological analysis of Iba1+ microglia using a deep learning assisted model
Frontiers in Cellular Neuroscience, 2022 There is growing evidence for the key role of microglial functional state in brain pathophysiology. Consequently, there is a need for efficient automated methods to measure the morphological changes distinctive of microglia functional states in research ...
Lucas Stetzik +14 more
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Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
npj Parkinson's Disease, 2021 Increasing evidence supports the role of brain and systemic inflammation in the etiology of Parkinson disease (PD). We used gene expression profiling to examine the activation state of peripheral blood monocytes in 18 patients with early, untreated PD ...
Samantha M. Carlisle +11 more
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Treatment of Psychotic Symptoms in ParkinsonÂ’s Disease [PDF]
Journal of Cytology & Histology, 2015 The treatment of Parkinson’s disease with l-dopa and a decarboxylase inhibitor, with dopamine agonists or with NMDA antagonists can cause psychotic symptoms. Neural networks are described in the mesolimbic system in order to explain this adverse effect.
Rafael Coveñas, Felix-Martin Werner
openaire +2 more sources
Nigrosome 1 imaging in REM sleep behavior disorder and its association with dopaminergic decline
Annals of Clinical and Translational Neurology, 2020 Objectives Rapid eye movement sleep behavior disorder (RBD) patients have a high risk of developing a Parkinsonian disorder, offering an opportunity for neuroprotective intervention. Predicting near‐term conversion, however, remains a challenge. Dopamine
Thomas R. Barber +7 more
doaj +1 more source
Journal of Biomedical Science, 2022 Background Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observed in Alzheimer’s disease (AD) and ...
Benjamin Chun-Kit Tong +12 more
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The Journal of Headache and Pain, 2021 Background Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3).
Mickael Aubignat +3 more
doaj +1 more source
Clinical Characteristics of Involuntary Movement in Hospitalized Patients [PDF]
Journal of Movement Disorders, 2019 Objective Neurological symptoms in hospitalized patients are not rare, and neurological consultation for movement disorders is especially important in evaluating or managing those with various movement disorders.
Kyum-Yil Kwon +3 more
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