Results 31 to 40 of about 236,137 (343)
npj Parkinson's Disease, 2022 Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative parkinsonism, and bedside assessments are needed to differentiate between these conditions. We examined 34 U.S.
Whitley W. Aamodt +6 more
doaj +1 more source
Additional file 1: of Cerebellar involvement in Parkinsonâ s disease resting tremor
, 2016 Summary Analysis Data. (DOCX 13 kb)
Lefaivre, Shannon +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda +3 more
wiley +1 more source
npj Parkinson's DiseaseUnderstanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia.
Quyen B. Do +13 more
doaj +1 more source
Unveiling new disease, pathway, and gene associations via multi-scale neural networks [PDF]
PLOS ONE, 15(4), p.e0231059 (2020), 2019 Diseases involve complex processes and modifications to the cellular machinery. The gene expression profile of the affected cells contains characteristic patterns linked to a disease. Hence, biological knowledge pertaining to a disease can be derived from a patient cell's profile, improving our diagnosis ability, as well as our grasp of disease risks ...
arxiv +1 more source
MOESM2 of Prevalence and incidence of Parkinsonâ s disease and drug-induced parkinsonism in Korea
, 2019 Additional file 2: Figure S1. Sensitivity analysis. Incidence of drug-induced parkinsonism in Korea.
Sola Han +5 more
openaire +1 more source
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
eLifeThe alpha-synuclein (αSyn) seeding amplification assay (SAA) that allows the generation of disease-specific in vitro seeded fibrils (SAA fibrils) is used as a research tool to study the connection between the structure of αSyn fibrils, cellular seeding ...
Selene Seoyun Lee +2 more
doaj +1 more source
Nature Communications, 2020 The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal +8 more
doaj +1 more source
The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]
, 2013 We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified ...
arxiv +1 more source