Results 51 to 60 of about 9,306,982 (363)

Prevalence of Parkinson’s disease across North America

npj Parkinson's Disease, 2018
Estimates of the prevalence of Parkinson’s disease in North America have varied widely and many estimates are based on small numbers of cases and from small regional subpopulations.
C. Marras, J. Beck, J. Bower, E. Roberts, B. Ritz, G. Ross, R. Abbott, R. Savica, S. K. Van Den Eeden, A. Willis, C.M. Tanner, on behalf of the Parkinson’s Foundation P4 Group   +11 more
semanticscholar   +1 more source

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede, Patricia Zvarova, Bahne H. Bahners, Andreas Horn   +3 more
wiley   +1 more source

Image-guided programming deep brain stimulation improves clinical outcomes in patients with Parkinson’s disease

npj Parkinson's Disease
Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). However, some patients may not respond optimally to clinical programming adjustments.
Viviana Torres, Kirsys Del Giudice, Pedro Roldán, Jordi Rumià, Esteban Muñoz, Ana Cámara, Yaroslau Compta, Almudena Sánchez-Gómez, Francesc Valldeoriola   +8 more
doaj   +1 more source

MOESM3 of A randomized controlled efficacy study of the Medido medication dispenser in Parkinsonâ s disease

, 2019
Additional file 3. Table with secondary outcomes of UPDRS-4.
K. Hannink, L. Brake, N.G.M. Oonk, A.A. Wertenbroek, M. Piek, L. Vree-Egberts, M.J. Faber, J. Palen, L.D. Dorresteijn   +8 more
openaire   +1 more source

CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Iñigo Ruíz‐Barrio, Javier Pagonabarraga, Anna Vázquez‐Oliver, Andrea Horta‐Barba, Jaime Kulisevsky, Saül Martínez‐Horta   +7 more
wiley   +1 more source

Additional file 1: of Ceruloplasmin functional changes in Parkinsonâ s disease-cerebrospinal fluid

, 2015
Figure S1. Western blot analysis for contaminant hemoglobin detection. Figure S2. Immunoprecipitation of both resting- and oxidized-ceruloplasmin.Table S1. Spectrophotometric analysis for hemoglobin contaminant detection in CSF samples. (PDF 1445 kb)
Barbariga, Marco, Curnis, Flavio, Annapaola Andolfo, Zanardi, Alan, Lazzaro, Massimo, Conti, Antonio, Magnani, Giuseppe, Volontè, Maria, Ferrari, Laura, Comi, Giancarlo, Corti, Angelo, Alessio, Massimo   +11 more
openaire   +1 more source

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease

Nature Genetics, 2014
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and
M. Nalls, N. Pankratz, C. Lill, Chuong B. Do, D. Hernandez, D. Hernandez, M. Saad, M. Saad, M. Saad, A. Destefano, A. Destefano, E. Kara, J. Bras, M. Sharma, C. Schulte, Margaux F. Keller, S. Arepalli, Christopher T Letson, Connor Edsall, H. Stefánsson, Xinmin Liu, Hannah A. Pliner, Joseph H. Lee, R. Cheng, M. Ikram, J. Ioannidis, G. Hadjigeorgiou, J. Bis, Miguel Ángel Martínez, Miguel Ángel Martínez, J. Perlmutter, A. Goate, K. Marder, B. Fiske, Margaret Sutherland, G. Xiromerisiou, R. Myers, L. Clark, K. Stefánsson, J. Hardy, P. Heutink, Honglei Chen, N. Wood, H. Houlden, H. Payami, A. Brice, A. Brice, W. Scott, T. Gasser, L. Bertram, N. Eriksson, T. Foroud, A. Singleton   +52 more
semanticscholar   +1 more source

Coffee Consumption Is Associated With Later Age‐at‐Onset of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Observation studies suggest that coffee consumption may lower the risk and delay the age‐at‐onset (AAO) of Parkinson's disease (PD). The aim of this study was to explore the causal relationship and genetic association between coffee consumption and the AAO, risk, and progression of PD. Using Mendelian randomization, we identified a significant
Dariia Kuzovenkova, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +3 more
wiley   +1 more source

Effect of dopamine on limbic network connectivity at rest in Parkinson’s disease patients with freezing of gait

Translational Neuroscience
Freezing of gait (FOG) in Parkinson’s disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the ...
Quek Dione Y. L., Taylor Natasha, Gilat Moran, Lewis Simon J. G., Ehgoetz Martens Kaylena A.   +4 more
doaj   +1 more source

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity

Brain Sciences, 2017
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Ryoma Morigaki, Satoshi Goto
doaj   +1 more source