Results 51 to 60 of about 449,138 (190)

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

eLife
The alpha-synuclein (αSyn) seeding amplification assay (SAA) that allows the generation of disease-specific in vitro seeded fibrils (SAA fibrils) is used as a research tool to study the connection between the structure of αSyn fibrils, cellular seeding ...
Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen   +2 more
doaj   +1 more source

Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease [PDF]

, 2003
Background: Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown. Methods: We conducted a five-
Krack, P., Batir, A., Van Blercom, N., Chabardes, S., Fraix, V., Ardouin, C., Koudsie, A., Limousin, P.D., Benazzouz, A., LeBas, J.F., Benabid, A.-L., Pollak, P.   +11 more
core   +4 more sources

Essential Tremor and Parkinson’s Disease: Exploring the Relationship

Tremor and Other Hyperkinetic Movements, 2019
Background: There is longstanding controversy surrounding the possible link between essential tremor (ET) and Parkinson’s disease (PD). Inconsistent and unreliable diagnostic criteria may in part account for some of the difficulties in defining the ...
Arjun Tarakad, Joseph Jankovic
doaj   +1 more source

Randomized controlled trial of a home-based action observation intervention to improve walking in Parkinson disease [PDF]

, 2016
Published in final edited form as: Arch Phys Med Rehabil. 2016 May ; 97(5): 665–673. doi:10.1016/j.apmr.2015.12.029.OBJECTIVE: To examine the feasibility and efficacy of a home-based gait observation intervention for improving walking in Parkinson ...
Cronin-Golomb, Alice, Ellis, Terry D., Jaywant, Abhishek, Lin, Cheng-Chieh, Neargarder, Sandy, Roy, Serge   +5 more
core   +1 more source

Impulsive and Compulsive Behaviors in Parkinson’s Disease [PDF]

Frontiers in Aging Neuroscience, 2014
Impulsive and compulsive behaviors (ICBs) are a heterogeneous group of conditions that may be caused by long-term dopaminergic replacement therapy (DRT) of Parkinson's disease (PD). The spectrum of ICBs includes dopamine dysregulation syndrome (DDS), punding, and impulse control disorders (ICDs).We made a detailed review regarding the epidemiology ...
Zhang, Guoxin, Zhang, Zhentao, Liu, Ling, Yang, Jiaolong, Huang, Jinsha, Xiong, Nian, Wang, Tao   +6 more
openaire   +3 more sources

Live Imaging of Axonal Transport in the Motor Neurons of Drosophila Larvae

Bio-Protocol, 2017
Axonal transport, which is composed of microtubules, motor proteins and a variety of types of cargo, is a prominent feature of neurons. Monitoring these molecular dynamics is important to understand the biological processes of neurons as well as ...
Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai   +2 more
doaj   +1 more source

Lack of evidence for decreased protein stability in the 2397 (Met) haplotype of the leucine rich repeat kinase 2 protein implicated in Parkinson’s disease [PDF]

, 2017
Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the leading genetic cause of autosomal dominant familial Parkinson’s disease.
Anderton, Ryan S, Boulos, Sherif, Greene, Wayne, Hill, Lauren, Mastaglia, Frank L, Morris, Rhiannon   +5 more
core   +2 more sources

Parkinson’s Disease: Time, Place, Person and Survival

Siriraj Medical Journal, 2009
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Weerasak Muangpaisan, David Seidel, Hiroyuki Hori, Aju Mathews   +3 more
openaire   +1 more source

Additional file 1: of LRRK2 contributes to monocyte dysregulation in Parkinsonâ s disease

, 2019
Supplementary materials and methods. (PDF 1185 kb)
Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang, Brenner, David, Melrose, Heather, Bauer, Peter, Ludolph, Albert, Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen, Danzer, Karin   +11 more
openaire   +1 more source

Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

Translational Neurodegeneration, 2019
The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of neurodegenerative synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, is a well-accepted fact.
Naomi P. Visanji, Anthony E. Lang, Gabor G. Kovacs   +2 more
doaj   +1 more source