Results 61 to 70 of about 9,678,735 (383)

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Additional file 2: of LRRK2 contributes to monocyte dysregulation in Parkinsonâ s disease

, 2019
LRRK2 protein expression is significantly upregulated in monocytes from PD patients. (PDF 303 kb)
Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang, Brenner, David, Melrose, Heather, Bauer, Peter, Ludolph, Albert, Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen, Danzer, Karin   +11 more
openaire   +1 more source

Physical therapy and deep brain stimulation in Parkinson’s Disease: Protocol for a pilot randomized controlled trial [PDF]

, 2018
Background Subthalamic nucleus deep brain stimulation (STN-DBS) reduces tremor, muscle stiffness, and bradykinesia in people with Parkinson’s Disease (PD).
Duncan, Ryan P, Earhart, Gammon M, Garbutt, Jane M, Perlmutter, Joel S, Van Dillen, Linda R   +4 more
core   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

Translational Neurodegeneration, 2019
The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of neurodegenerative synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, is a well-accepted fact.
Naomi P. Visanji, Anthony E. Lang, Gabor G. Kovacs   +2 more
doaj   +1 more source

Additional file 1: of Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinsonâ s disease: what is the impact of Parkinsonâ s disease on surgical outcome?

, 2019
The assessment Scale Proposed by the Japanese Orthopaedic Association. The Japanese Orthopaedic Association Scoring system (JOA score) consists of 2 categories (subjective and objective symptoms), ranging from 0 (worst condition) to 15 (best condition). (DOCX 22 kb)
Watanabe, Kei, Katsumi, Keiichi, Ohashi, Masayuki, Shibuya, Yohei, Izumi, Tomohiro, Hirano, Toru, Endo, Naoto, Kaito, Takashi, Yamashita, Tomoya, Fujiwara, Hiroyasu, Yukitaka Nagamoto, Matsuoka, Yuji, Suzuki, Hidekazu, Hirosuke Nishimura, Hidetomi Terai, Tamai, Koji, Tagami, Atsushi, Syuta Yamada, Adachi, Shinji, Toshitaka Yoshii, Shuta Ushio, Harimaya, Katsumi, Kawaguchi, Kenichi, Yokoyama, Nobuhiko, Oishi, Hidekazu, Doi, Toshiro, Kimura, Atsushi, Inoue, Hirokazu, Inoue, , Miyagi, Masayuki, Saito, Wataru, Nakano, Atsushi, Sakai, Daisuke, Nukaga, Tadashi, Ikegami, Shota, Shimizu, Masayuki, Futatsugi, Toshimasa, Ohtori, Seiji, Furuya, Takeo, Sumihisa Orita, Imagama, Shiro, Ando, Kei, Kobayashi, Kazuyoshi, Kiyasu, Katsuhito, Murakami, Hideki, Yoshioka, Katsuhito, Seki, Shoji, Hongo, Michio, Kakutani, Kenichiro, Yurube, Takashi, Yasuchika Aoki, Oshima, Masashi, Takahata, Masahiko, Iwata, Akira, Hirooki Endo, Abe, Tetsuya, Tsukanishi, Toshinori, Nakanishi, Kazuyoshi, Watanabe, Kota, Hikata, Tomohiro, Suzuki, Satoshi, Isogai, Norihiro, Eijiro Okada, Funao, Haruki, Ueda, Seiji, Shiono, Yuta, Nojiri, Kenya, Naobumi Hosogane, Ishii, Ken   +68 more
openaire   +1 more source

Inverse comorbidity: the power of paradox in the advancement of science [PDF]

, 2013
Research on comorbidity and multimorbidity is finally receiving the attention it deserves, particularly considering the magnitude and impact they have on health and the delivery of healthcare [1,2].
Tabarés-Seisdedos, Rafael, Valderas, Jose M.   +1 more
core   +3 more sources

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source

Image-guided programming deep brain stimulation improves clinical outcomes in patients with Parkinson’s disease

npj Parkinson's Disease
Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). However, some patients may not respond optimally to clinical programming adjustments.
Viviana Torres, Kirsys Del Giudice, Pedro Roldán, Jordi Rumià, Esteban Muñoz, Ana Cámara, Yaroslau Compta, Almudena Sánchez-Gómez, Francesc Valldeoriola   +8 more
doaj   +1 more source

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Nature Communications, 2020
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber   +8 more
doaj   +1 more source