Results 71 to 80 of about 9,306,982 (363)

Genetic Diversity and Expanded Phenotypes in Dystonia: Insights From Large‐Scale Exome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (~25%), the etiology in most patients remains elusive. Moreover, understanding correlations between clinical manifestations and genetic variants has become increasingly ...
Mirja Thomsen, Fabian Ott, Sebastian Loens, Gamze Kilic‐Berkmen, Ai Huey Tan, Shen‐Yang Lim, Ebba Lohmann, Kaja M. Schröder, Lea Ipsen, Lena A. Nothacker, Linn Welzel, Alexandra S. Rudnik, Frauke Hinrichs, Thorsten Odorfer, Kirsten E. Zeuner, Friederike Schumann, Andrea A. Kühn, Simone Zittel, Marius Moeller, Robert Pfister, Christoph Kamm, Anthony E. Lang, Yi Wen Tay, Ana Luísa de Almeida Marcelino, Marie Vidailhet, Emmanuel Roze, Joel S. Perlmutter, Jeanne S. Feuerstein, Victor S. C. Fung, Florence Chang, Richard L. Barbano, Steven Bellows, Aparna A. Wagle Shukla, Alberto J. Espay, Mark S. LeDoux, Brian D. Berman, Stephen Reich, Andres Deik, Andre Franke, Michael Wittig, Sören Franzenburg, Jens Volkmann, Norbert Brüggemann, H. A. Jinnah, Tobias Bäumer, Christine Klein, Hauke Busch, Katja Lohmann   +47 more
wiley   +1 more source

MOESM1 of Brain mediators of systemic oxidative stress on perceptual impairments in Parkinsonâ s disease

, 2015
Additional file 1. Detail T1-weighted structural MRI image processing procedures.
Wei-Che Lin, Kun-Hsien Chou, Lee, Pei-Lin, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu, Ching-Po Lin   +12 more
openaire   +1 more source

The MSA Atrophy Index (MSA‐AI): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reliable biomarkers are essential for tracking disease progression and advancing treatments for multiple system atrophy (MSA). In this study, we propose the MSA Atrophy Index (MSA‐AI), a novel composite volumetric measure to distinguish MSA from related disorders and monitor disease progression. Methods Seventeen participants with an
Paula Trujillo, Kilian Hett, Amy Cooper, Amy E. Brown, Jessica Iregui, Manus J. Donahue, M. Erik Landman, Italo Biaggioni, Margaret Bradbury, Cynthia Wong, David Stamler, Daniel O. Claassen   +11 more
wiley   +1 more source

Online cognitive monitoring technology for people with Parkinson’s disease and REM sleep behavioural disorder

npj Digital Medicine
Automated online cognitive assessments are set to revolutionise clinical research and healthcare. However, their applicability for Parkinson’s Disease (PD) and REM Sleep Behavioural Disorder (RBD), a strong PD precursor, is underexplored.
Maria Bălăeţ, Falah Alhajraf, Tanja Zerenner, Jessica Welch, Jamil Razzaque, Christine Lo, Valentina Giunchiglia, William Trender, Annalaura Lerede, Peter J. Hellyer, Sanjay G. Manohar, Paresh Malhotra, Michele Hu, Adam Hampshire   +13 more
doaj   +1 more source

Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study

Translational Neurodegeneration, 2020
Background The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials.
Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães, Patrício Soares-da-Silva, the OPTIPARK investigators   +5 more
doaj   +1 more source

MOESM1 of A randomized controlled efficacy study of the Medido medication dispenser in Parkinsonâ s disease

, 2019
Additional file 1. Table with secondary outcomes of PDQ-39.
K. Hannink, L. Brake, N.G.M. Oonk, A.A. Wertenbroek, M. Piek, L. Vree-Egberts, M.J. Faber, J. Palen, L.D. Dorresteijn   +8 more
openaire   +1 more source

Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease

Nature Genetics, 2009
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the ...
J. Simón-Sánchez, C. Schulte, J. Bras, M. Sharma, J. Gibbs, Daniela Berg, C. Paisán-Ruiz, P. Lichtner, Sonja W. Scholz, D. Hernandez, R. Krüger, Monica Federoff, Christine Klein, A. Goate, J. Perlmutter, M. Bonin, Michael A. Nalls, T. Illig, C. Gieger, H. Houlden, M. Steffens, M. Okun, B. Racette, M. Cookson, K. Foote, Hubert H. Fernandez, B. Traynor, S. Schreiber, S. Arepalli, Ryan R. Zonozi, K. Gwinn, Marcel P. van der Brug, G. Lopez, S. J. Chanock, A. Schatzkin, Yikyung Park, A. Hollenbeck, Jianjun Gao, Xuemei Huang, Nick W. Wood, D. Lorenz, G. Deuschl, Honglei Chen, O. Riess, John A Hardy, Andrew B. Singleton, Thomas Gasser   +46 more
semanticscholar   +1 more source

Paroxysmal Dyskinesias Secondary to HHV‐6A Encephalitis: The First Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paroxysmal dyskinesias encompasses a spectrum of conditions marked by intermittent involuntary movements, with paroxysmal kinesigenic dyskinesias being the most common phenotype. Central nervous system infection is a rare cause of paroxysmal dyskinesias.
Zhuoran Wang, Haiting Li, Xiaoping Du, Qiong Wang, Yating Zhang, Huifang Wang   +5 more
wiley   +1 more source

Reply to Comment on Re-Visiting Immunogenicity Associated with Botulinum Toxin Treatment. Toxins 2019, 11, 491

Toxins, 2020
We appreciate the commentary on our article by Foster and Beard, both employees of Ipsen [...]
Steven Bellows, Joseph Jankovic
doaj   +1 more source

Additional file 2: of Meta-analysis of risk factors for Parkinsonâ s disease dementia

, 2016
Details of the study results. This file provided detailed results of meta-analysis of each risk factor. (DOCX 159 kb)
Yaqian Xu, Yang, Jing, Huifang Shang
openaire   +1 more source