Results 111 to 120 of about 125,678 (274)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Impact of Ethnicity on Non-Motor Symptoms of Parkinson's Disease

Journal of Parkinson’s Disease, 2012
Parkinson's disease (PD) is a neurodegenerative illness characterized by various non-motor symptoms that may contribute to disability, impaired quality of life and shortened life expectancy.
Abdul Qayyum Rana, Aysha Athar, Aida Owlia, Ishraq Siddiqui, Naeem Awan, Abdul Fattah, Mohammed A. Rana   +6 more
doaj   +1 more source

Informed consent decision-making in deep brain stimulation [PDF]

, 2018
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious.
Appelbaum, Bell, Berg, Gilbert, Grisso, Jahanshahi, Mehdorn   +6 more
core   +2 more sources

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]

, 2019
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato, Flavia Mulè, Simona Terzo   +2 more
core   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

ICF-Based Disability Survey in a Rural Population of Adults and Older Adults Living in Cinco Villas, Northeastern Spain: Design, Methods and Population Characteristics [PDF]

, 2010
Background: This article describes the methods of a door-to-door screening survey exploring the distribution of disability and its major determinants in northeastern Spain.
Alberto Larrosa, Luis, Alcalde Cabero, Enrique, Almazan Isla, Javier, Avellanal, Fuencisla, Burzaco, Olga, Cieza, Alarcos, Comin Comin, Magdalena, Damian, Javier, de Pedro-Cuesta, Jesus, Frades, Belen, Franco, Esther, Joao Forjaz, Maria, Magallon, Rosa, Manuel Castellote, Juan, Martin Garcia, Gloria, Martinez Martin, Pablo, Martinez, Cristina, Pastor-Barriuso, Roberto, Pena Jimenez, Ana, Poblacion Martinez, Adolfo, Reed, Geoffrey, Ruiz, Cristina, Virues-Ortega, Javier   +22 more
core   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme

BMC Medicine
Background People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time.
Anthony Martyr, Laura D. Gamble, Anna Hunt, Catherine Quinn, Robin G. Morris, Catherine Henderson, Louise Allan, Carol Opdebeeck, Catherine Charlwood, Roy W. Jones, Claire Pentecost, Michael D. Kopelman, Jeanette M. Thom, Fiona E. Matthews, Linda Clare   +14 more
doaj   +1 more source

Inter-hemispheric EEG coherence analysis in Parkinson's disease : Assessing brain activity during emotion processing [PDF]

, 2014
Parkinson’s disease (PD) is not only characterized by its prominent motor symptoms but also associated with disturbances in cognitive and emotional functioning.
A Ariatti, A Cronin-Golomb, A Morita, A Suzuki, A Tessitore, AD Lawrence, AD Lawrence, AEB Cancelliere, AF Leuchter, AT Beck, B Pillon, BE Levin, C Dara, C Schröder, CC French, CF Lima, CL Yeager, D Bowers, D Schellberg, E Mohr, G Nolte, GG Celesia, H Cohen, H Hinrichs, H Kober, HL Chen, HM Gray, IH Gotlib, J Busk, J Mikels, J Péron, J Redondo, JA Obeso, JC Shaw, JF Caekebeke, JJ Gross, JM Savitt, JT Yip, K Dujardin, K Sergerie, Kenneth Sundaraj, KH Kim, Khairiyah Mohamad, KM Miller, LC Fonseca, M Lotze, M Murugappan, M. Murugappan, M. Satiyan, MA Guevara, MD Pell, MD Pell, MF Folstein, MI Ventura, MJ Wieser, MJ Wieser, MK Beyer, MM Hoehn, Mohd Iqbal Omar, MY Neufeld, Norlinah Mohamed Ibrahim, P Garrido-Vásquez, P Madeley, P Salgado-Pineda, PC Petrantonakis, PJ Lang, R Adolphs, R Adolphs, R Bastiaanse, R Soikkeli, R Sprengelmeyer, R Yuvaraj, R. Palaniappan, R. Yuvaraj, RA Roemer, RC Oldfield, RJ Davidson, RJR Blair, RW Thatcher, S Jerritta, S Paulmann, SK Hadjidimitriou, T Baumgartner, T Gasser, TF Newton, TP Bouchard, US Clark, Y Kan, Y Wang   +88 more
core   +1 more source