Results 101 to 110 of about 68,677 (270)

Exidavnemab binds to aggregated α-synuclein in human brains affected by α-synucleinopathies

Neurotherapeutics
Abnormal accumulation of α-synuclein in neuronal and/or glial cells occurs in a range of neurodegenerative conditions, including Parkinson’s disease, Parkinson’s disease dementia, dementia with Lewy bodies, and multiple system atrophy.
Olof Zachrisson, Malin Johannesson, Linda Söderberg, Fredrik Eriksson, Dan Sunnemark, Eva Nordström, My Björklund, Emily B. Button, Tomas Odergren, Christer Möller, Gunilla Osswald, Lars Lannfelt, Johanna Fälting   +12 more
doaj   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Neuropathology in mice expressing mouse alpha-synuclein [PDF]

, 2011
?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries a threonine at position 53 ...
Kahle, Philipp J., Ksiazek, Iwona, Derya R Shimshek, Markus A Ruegg, Rieker Claus, Cindy Boden, Ruegg Markus A., Derya R. Shimshek, Dev, Kumlesh K., Simone Danner, Heinrich Schell, Herman van der Putten, Claus Rieker, Ruegg, Markus A., Philipp J Kahle, Iwona Ksiazek, Boden Cindy, Kumlesh K Dev, Sabine Kauffmann, Schell, Heinrich, van der Putten Herman, Kauffmann Sabine, Dev Kumlesh K., Kumlesh K. Dev, Shimshek, Derya R., Lehnhoff Katja, Ksiazek Iwona, Katja Lehnhoff, Shimshek Derya R., Schell Heinrich, Rieker, Claus, Samuel Barbieri, Philipp J. Kahle, van der Putten, Herman, Kauffmann, Sabine, Lehnhoff, Katja, Markus A. Ruegg, Kahle Philipp J., Danner, Simone, Barbieri, Samuel, Danner Simone, Boden, Cindy, Barbieri Samuel   +42 more
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The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Development of screening guidelines and clinical criteria for predementia Alzheimer's disease [PDF]

, 2008
Item does not contain fulltextBACKGROUND: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and
De Deyn, PP, Tsolaki, M, J. Touchon, M. Tsolaki, L. Spiru, Spiru, L., Scheltens, P., Verhey, F. R. J., de Deyn, P.P., B. Vellas, Elina, K., J. Jolles, Boada, M., Frisoni, G., Wilcock, G, R. Bullock, Nobili, F, Touchon, J, Olde Rikkert, M., Hampel, H, Frolich, L, Verhey, F.R.J., M. Olde Rikkert, Rikkert, M.O., Ousset, P. -J., L. Minthon, M. Boada, Frisoni, GB, Lund University., Jones, R., Frisoni, G. B., P. Scheltens, Wahlund, L. -O., Spiru, L, Wilcock, G., F.R.J. Verhey, Ousset, PJ, Froelich, L., Deyn, P.P. de, Vellas, B, Winblad, B., G. Wilcock, Frolich, L., Ousset, P.J., Hampel, H., R. Jones, L.-O. Wahlund, De Deyn, P. P., H. Hampel, Minthon, Lennart,, Touchon, J., Jones, R, F. Nobili, Soininen, H., Rikkert, M. Olde, Olde Rikkert, M, G.B. Frisoni, NOBILI, FLAVIO MARIANO, Vellas, B., Minthon, Lennart, P.-J. Ousset, Reynist, E., Minthon, L, B. Winblad, Bullock, R., Frisoni, G.B., Minthon, L., Boada, M, Bullock, R, Winblad, B, Wahlund, L.O., Rigaud, A.S., Rigaud, A. S., Visser, P.J., Ousset, P.-J., Visser, PJ, Wahlund, Lars-Olof, Rigaud, AS, P.J. Visser, Nobili, F., P.P. De Deyn, Frölich, Lutz, Visser, P. J., Tsolaki, M., Jolles, J., Olde Rikkert, M.G.M., Wahlund, L. O., Wahlund, LO, Verhey, FR, Scheltens, P, A.-S. Rigaud, Soininen, H, L. Frölich, Ousset, P. J., Rigaud, A.-S., Jolles, J, Rigaud, A. -S., H. Soininen   +97 more
core   +1 more source

Impaired event-related theta spectral coherence in emotional facial expression processing in neurodegenerative disorders

Frontiers in Human Neuroscience
IntroductionThe ability to recognize emotional facial expressions relies on brain functional networks, particularly in the right hemisphere, and is impaired in neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease.
Hakan Uzunlar, Rümeysa Duygun, Rümeysa Duygun, Rümeysa Duygun, İlayda Kıyı-Atilla, Tuba Aktürk, Tuba Aktürk, Ebru Yıldırım, Ebru Yıldırım, Nesrin Helvacı Yılmaz, Lütfü Hanoğlu, Henrique Sequeira, David Papo, David Papo, Massimiliano Zanin, Claudio Babiloni, Claudio Babiloni, Görsev Yener, Görsev Yener, Bahar Güntekin, Bahar Güntekin   +20 more
doaj   +1 more source

Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

Behavioural Neurology, 2013
Visual Hallucinations (VH) are a common non-motor symptom of Parkinson’s Disease (PD) and the Lewy body dementias (LBD) of Parkinson's disease with dementia (PDD) and Dementia with Lewy Bodies (DLB).
M. Onofrj, J. P. Taylor, D. Monaco, R. Franciotti, F. Anzellotti, L. Bonanni, V. Onofrj, A. Thomas   +7 more
doaj   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

The bioenergetic status relates to dopamine neuron loss in familial PD with PINK1 mutations

, 2012
Mutations in the PINK1 gene cause autosomal recessive familial Parkinson’s disease (PD). The gene encodes a mitochondrial protein kinase that plays an important role in maintaining mitochondrial function and integrity.
Johann Hagenah, Neumaier, Bernd, Roggendorf, J., Julia Roggendorf, Roggendorf, Julia, Johannes C Klein, Hattingen, E., Steinmetz, H., Hagenah, Johann, Hagenah, J., Klein, Johannes C., Eggers, C., Hilker, Rüediger, Klein, Christine, Hattingen, Elke, Klein, C., Fink, Gereon R., Pilatus, U., Ulrich Pilatus, Elke Hattingen, Bernd Neumaier, Klein, Johannes Christian, Baudrexel, S., Hilker, Rüdiger, Eggers, Carsten, Neumaier, B., Hagenah, Johann Meinert, Carsten Eggers, Klein, J., Helmuth Steinmetz, Fink, Gereon Rudolf, Steinmetz, Helmuth, Pilatus, Ulrich, Fink, G., Rüediger Hilker, Baudrexel, Simon, Gereon R Fink, Christine Klein, Hilker, R., Simon Baudrexel   +39 more
core   +1 more source