Results 81 to 90 of about 68,677 (270)

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]

, 2009
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile, Paleologou Katerina, Vitte Jérémie, Duchateau, René, Corti, Olga, Hamon Michel, Perez-Diaz, Fernando, Fournier Margot, Fernando Perez-Diaz, Saurini, Françoise, Traver, Sabine, Katerina Paleologou, Joubert, Chantal, Hilal A Lashuel, Christian Haass, Philipp J Kahle, Jean-Philippe Dullin, Charles Duyckaerts, Joubert Chantal, Garrigue Jérôme, Ardila-Osorio Héctor, Langui, Dominique, Michel Hamon, Jérémie Vitte, Margot Fournier, Cornilleau Fabien, Paleologou, Katerina, Duyckaerts Charles, Hanoun Naïma, Françoise Saurini, Corti Olga, Cécile Goujet-Zalc, Kahle Philipp J., Fabien Cornilleau, Haass Christian, Alexis Brice, Naïma Hanoun, Kahle, Philipp J., Cohen-Salmon, Charles, Dullin, Jean-Philippe, Fournier, Margot, Olga Corti, Hamon, Michel, Chantal Joubert, Vitte, Jérémie, René Duchateau, Cohen-Salmon Charles, Dominique Langui, Héctor Ardila-Osorio, Kahle, Philipp J, Traver Sabine, Cornilleau, Fabien, Lashuel Hilal A., Duchateau René, Jérôme Garrigue, Ardila-Osorio, Héctor, Langui Dominique, Garrigue, Jérôme, Haass, Christian, Lashuel, Hilal A., Brice Alexis, Duyckaerts, Charles, Brice, Alexis, Charles Cohen-Salmon, Perez-Diaz Fernando, Sabine Traver, Lashuel, Hilal A, Saurini Françoise, Goujet-Zalc, Cécile, Dullin Jean-Philippe, Hanoun, Naïma   +70 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Immune cells play a mediating role in the relationship between the gut microbiota and dementia: A Mendelian randomization study

Innate Immunity
Introduction The gut microbiota modulates dementia pathogenesis through immune interactions. Using Mendelian randomization, we investigate immune mediated mechanisms linking microbial dysbiosis to four dementia subtypes (Alzheimer's disease ...
Jianzhun Chen, Liuhui Zhu, Jie Liu, Jieyu Chen, Chunyu Liang, Chenxi Liu, Fang Wang, Yongyun Zhu, Xinglong Yang   +8 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Piece of Mind: knowledge translation performances for public engagement on Parkinson’s disease and dementia

Frontiers in Psychology
IntroductionThe subjective experience of illness is often overshadowed by the disease-and-cure focus of health research, contributing to the stigmatization of conditions such as Parkinson’s disease and dementia.
Naila Kuhlmann, Naila Kuhlmann, Aliki Thomas, Aliki Thomas, Natalia Incio-Serra, Stefanie Blain-Moraes   +5 more
doaj   +1 more source

Risk of dementia and Parkinson's disease in patients treated with androgen deprivation therapy using gonadotropin-releasing hormone agonist for prostate cancer: A nationwide population-based cohort study.

PLoS ONE, 2020
Recent studies reported conflicting results on the association of androgen deprivation therapy (ADT) with dementia and Parkinson's disease in patients with prostate cancer (Pca).
Myungsun Shim, Woo Jin Bang, Cheol Young Oh, Yong Seong Lee, Seong Soo Jeon, Hanjong Ahn, Young-Su Ju, Jin Seon Cho   +7 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Dementia in Parkinson’s disease

, 2020
Lewy body dementia includes Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), and is the second most common form of dementia after Alzheimer’s disease (AD).
Hu, Michele, Baig, Fahd
core   +1 more source

Neural correlates of early cognitive dysfunction in Parkinson's disease

Annals of Clinical and Translational Neurology, 2019
Objective Dementia is a common and feared aspect of Parkinson's disease but there are no robust predictors of cognitive outcome. Visuoperceptual deficits are linked to risk of dementia in Parkinson's disease but whether they predict cognitive change is ...
Rimona S. Weil, Joel S. Winston, Louise‐Ann Leyland, Katerina Pappa, Ribeya B. Mahmood, Huw R. Morris, Geraint Rees   +6 more
doaj   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source