Results 121 to 130 of about 125,678 (274)

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, EarlyView.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Dementia and functional decline in patients with Parkinson's disease

Dementia & Neuropsychologia
Functional decline in Parkinson's disease (PD), characterized by reduced ability to carry out activities of daily living, usually results from typical motor impairment and may be aggravated by concomitant cognitive impairment.
Florindo Stella, Claudio Eduardo Muller Banzato, Elizabeth Maria Aparecida Barasnevicius Quagliato, Maura Aparecida Viana, Gustavo Christofoletti   +4 more
doaj   +1 more source

Association between Plasma P‐tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Clinically relevant Alzheimer's disease co‐pathology is common in Lewy body disorders. Plasma P‐tau217 is a sensitive biomarker for amyloid and tau pathology in Alzheimer's disease. The objective was to determine if plasma P‐tau217 associates with Alzheimer's disease co‐pathology and cognition in Lewy body disorders. Methods Participants had (
Thomas F. Tropea, Patricia Aldea Stevenson, Matthew Flitter, David Meehan, Amanda Morris, Ming Lu, Leonardo Iaccarino, Emily C. Collins, Michael E. Hodsdon, David Irwin, Meredith Spindler, Andres Deik, Nabila Dahodwala, Katheryn A.Q. Cousins, David A. Wolk, Leslie Shaw, Daniel Weintraub, Edward B. Lee, Alice Chen‐Plotkin, Mark Mintun, Andrew Siderowf   +20 more
wiley   +1 more source

11C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia

Annals of Clinical and Translational Neurology, 2019
There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as 11C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated ...
Nicolas Nicastro, Ajenthan Surendranathan, Elijah Mak, James B. Rowe, John T. O’Brien   +4 more
doaj   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

Referrals to allied health professionals for people with dementia: an analysis of general practitioner data from two Australian primary health networks

Family Medicine and Community Health
Objective To examine general practitioners’ (GPs) referral patterns to allied health services for people with dementia compared with those without dementia across two large Australian Primary Health Networks (PHNs).Design A retrospective cohort study ...
Kate Swaffer, Grant Russell, Michele L Callisaya, Velandai Srikanth, Yalchin Oytam, Lee-Fay Low, Den-Ching A. Lee, Taya A. Collyer, Nadine E. Andrew, Claire M.C. O’Connor, Keith D. Hill, Natasha Layton, Barbara Barbosa Neves, Galina Daraganova, Catherine Devanny   +14 more
doaj   +1 more source

Cerebrospinal fluid and serum MHPG improve Alzheimer's disease versus dementia with Lewy bodies differential diagnosis

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Given the challenges concerning the differential diagnosis of dementia, we investigated the possible added value of monoaminergic compounds to the standard cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers.
Jana Janssens, Yannick Vermeiren, Erik Fransen, Tony Aerts, Debby Van Dam, Sebastiaan Engelborghs, Peter P. De Deyn   +6 more
doaj   +1 more source

Moving beyond neurophobia to cultivate the neuroquisitive learner

Anatomical Sciences Education, EarlyView.
Abstract “Neurophobia,” a pervasive fear of the neurological sciences, poses a significant barrier in medical education, affecting learners and physicians worldwide. Its consequences are far‐reaching, contributing to a limited neurology workforce and diminished confidence among non‐specialists in managing neurological conditions.
Joanna R. Appel, Kirsten A. Porter‐Stransky   +1 more
wiley   +1 more source

Prevalence of living alone with dementia and other progressive neurological conditions: findings from primary care data in England

BMC Medicine
Background Living alone with a neurodegenerative condition such as dementia may result in inequalities in access to support and resources. However, estimates of the number of people living alone vary widely in research studies.
Laura D. Gamble, Linda Clare, Anthony Martyr, Maria Caulfield, Catherine Charlwood, Claire Hulme, Jan R. Oyebode, Matthew Prina   +7 more
doaj   +1 more source

Mild Cognitive Impairment in Parkinson’s Disease: A Review of Current Concepts

Neurology Research International, 2013
Mild Cognitive Impairment in Parkinson’s Disease (PD-MCI) is common and may be associated with accelerated progression to dementia. Considering the importance of this emerging entity, new diagnostic criteria have recently been proposed. Early recognition
Natalie C. Palavra, Sharon L. Naismith, Simon J. G. Lewis   +2 more
doaj   +1 more source