Results 41 to 50 of about 125,678 (274)

Investigating the interaction between neuropsychiatry features and daily activities on social function in patients with Parkinson's disease with mild cognitive impairment

BJPsych Open, 2022
Background Social functioning is crucial for daily living and is an essential indicator of dementia in patients with Parkinson's disease. The pattern of social functioning in patients with Parkinson's disease without dementia (i.e.
Yi-Ru Chen, Chun-Hsiang Tan, Hui-Chen Su, Chung-Yao Chien, Pi-Shan Sung, Tien-Yu Lin, Tsung-Lin Lee, Rwei-Ling Yu   +7 more
doaj   +1 more source

Additional file 2: Table S1. of Guidelines for dementia or Parkinsonâ s disease with depression or anxiety: a systematic review

, 2016
Grey Literature Sources (n = 83). (DOCX 15Â kb)
Goodarzi, Zahra, Mele, Bria, Selynne Guo, Hanson, Heather, Jette, Nathalie, Patten, Scott, Pringsheim, Tamara, Jayna Holroyd-Leduc   +7 more
openaire   +1 more source

Additional file 1: Box S1. of Guidelines for dementia or Parkinsonâ s disease with depression or anxiety: a systematic review

, 2016
Search Strategy. (DOCX 22Â kb)
Goodarzi, Zahra, Mele, Bria, Selynne Guo, Hanson, Heather, Jette, Nathalie, Patten, Scott, Pringsheim, Tamara, Jayna Holroyd-Leduc   +7 more
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

From allegory to conceptualization, hypothesis and finally evidences: Alzheimer’s dementia, Parkinson's disease "gut–brain axis" and their preclinical phenotype

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Researchers are constantly trying to develop therapeutic targets in neurodegenerative disorders like Alzheimer's dementia and Parkinson's disease. Despite enormous endeavors, there are several unmet needs.
Souvik Dubey, Ritwik Ghosh, Mahua Jana Dubey, Samya Sengupta, Shambaditya Das   +4 more
doaj   +1 more source

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]

, 2017
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, David, Karen K., Dawson, Ted M., Dewey, Richard B., Jr., Foroud, Tatiana, German, Dwight, Gwinn, Katrina, Huang, Xuemei, Lungu, Codrin, Petyuk, Vlad, Potashkin, Judith A., Rosenthal, Liana S., Saunders-Pullman, Rachel, Scherzer, Clemens R., Sieber, Beth-Anne, St Hillaire-Clarke, Coryse, Sutherland, Margaret, Swanson-Fischer, Christine, Vaillancourt, David E., Walt, David R., West, Andrew B., Zhang, Jing   +25 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

BMC Medicine, 2007
Background Statins are a class of medications that reduce cholesterol by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Whether statins can benefit patients with dementia remains unclear because of conflicting results.
Li Nien-Chen, Wang Stanley W, Wolozin Benjamin, Lee Austin, Lee Todd A, Kazis Lewis E   +5 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease:A task-based fMRI study [PDF]

, 2015
Background: The neural substrates of visual hallucinations remain an enigma, due primarily to the difficulties associated with directly interrogating the brain during hallucinatory episodes.
Halliday, Glenda M., Hornberger, Michael, Lewis, Simon J. G., Muller, Alana J., O’Callaghan, Claire, Shine, James M.   +5 more
core   +1 more source