Results 11 to 20 of about 108,963 (268)

Familial Parkinson’s Disease/Parkinsonism [PDF]

BioMed Research International, 2015
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD patients are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD.
Hiroyuki Tomiyama, Suzanne Lesage, Eng-King Tan, Beom S. Jeon   +3 more
openaire   +2 more sources

Clinical neurophysiology of Parkinson’s disease and parkinsonism [PDF]

Clinical Neurophysiology Practice, 2022
This review is part of the series on the clinical neurophysiology of movement disorders. It focuses on Parkinson's disease and parkinsonism. The topics covered include the pathophysiology of tremor, rigidity and bradykinesia, balance and gait disturbance and myoclonus in Parkinson's disease.
Chen, Robert, Berardelli, A., Bhattacharya, A., Bologna, M., Chen, K.S., Fasano, A., Helmich, R.C.G., Helmich, R.C.G., Hutchison, W.D., Kamble, N., Kühn, A.A., Macerollo, A., Neumann, W.J., Pal, P.K., Paparella, G., Suppa, A., Udupa, K.   +16 more
openaire   +4 more sources

Exploring the multifaceted neuroprotective actions of gallic acid: a review

International Journal of Food Properties, 2020
Much attention has been recently given to the effect of diet compounds on physical and mental health. Gallic acid is a phenolic compound with antioxidant activity.
Sahreh Shabani, Zahra Rabiei, Hossein Amini-Khoei   +2 more
doaj   +1 more source

Intermittent theta-burst stimulation combined with physical therapy as an optimal rehabilitation in Parkinson’s disease: study protocol for a randomised, double-blind, controlled trial

Trials, 2023
Background First-line rehabilitative strategies to improve motor deficits are based on functional training (physical or occupational therapy), which has been demonstrated to facilitate neural reorganisation.
Zhao-hui Jin, Yi-xuan Wang, De-tao Meng, Yi Qin, Yi-nan Duan, Jin-ping Fang, Rui-dan Wang, Yan-jun Liu, Cui Liu, Ping Wang, Hong-jiao Yan, Yi Zhen, Xia An, Ke-ke Chen, Xin Yu, Diyang Lyu, Xiao-Yan Yan, Bo-yan Fang   +17 more
doaj   +1 more source

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

eLife, 2022
Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral pathogens. STING binds TANK-binding kinase 1 (TBK1).
Eva M Szego, Laura Malz, Nadine Bernhardt, Angela Rösen-Wolff, Björn H Falkenburger, Hella Luksch   +5 more
doaj   +1 more source

Parkinson’s Disease and Parkinsonism

The Journal of Turkish Family Physician, 2022
Parkinson’s disease (PD), or paralysis agitans is a common neurodegenerative and heterogeneous disorder. Parkinson’s symptoms include bradykinesia, rigidity and tremor. PD is pathologically characterized by the loss of dopaminergic neurons of the substantia nigra. Treatment involves pharmacologic and nonpharmacologic approaches.
Tuba Erdoğan Soyukibar, Dilaver Kaya
openaire   +1 more source

Ambroxol therapy for Parkinson’s disease: Systematic literature review [PDF]

Romanian Journal of Neurology, 2023
Parkinson’s disease (PD) is the second most common neurodegenerative disease. The accumulation of α-synuclein protein in the basal ganglia is the underlying pathogenesis of PD. Genetic abnormalities are one of the predisposing factors for PD.
Virgi Mayang Maharani, Ken Wirastuti, Meyvita Silviana, Naili Sofi Riasari   +3 more
doaj   +1 more source

Efectividad de tres métodos de estimación de edad dental en personas adultas vivas - Región Huánuco

Revista Peruana de Ciencias de la Salud, 2023
Objetivo. Determinar la efectividad de tres métodos de estimación de edad dental en personas adultas vivas de la región de Huánuco. Métodos. Fue una investigación aplicada de diseño transversal, a partir de un estudio correlacional, comparativo, de ...
Ronald Christian Solís Adrianzèn
doaj   +1 more source

Influencia de la microbiota intestinal en la enfermedad de Parkinson. Revisión

Revista Peruana de Ciencias de la Salud, 2023
El objetivo del presente estudio es analizar el papel de la microbiota intestinal en la progresión de la enfermedad de Parkinson, realizando una revisión bibliográfca.
Alejandra Belen Maldonado Gomez, Valerie Marianne Soruco Vera, Nelson Franco Condori Salluco, Johnny Brandon Merida Copa   +3 more
doaj   +1 more source

Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?

Frontiers in Molecular Neuroscience, 2018
The role of phagocytosis in the neuroprotective function of microglia has been appreciated for a long time, but only more recently a dysregulation of this process has been recognized in Parkinson’s disease (PD).
Elzbieta Janda, Laura Boi, Anna R. Carta
doaj   +1 more source