Results 31 to 40 of about 496,828 (359)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
TrialsBackground The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within the beta frequency range.
Hong-yu Zhang +16 more
doaj +1 more source
Dynamical Role of Pivotal Brain Regions in Parkinson Symptomatology Uncovered with Deep Learning
Brain Sciences, 2020 Background: The release of a broad, longitudinal anatomical dataset by the Parkinson’s Progression Markers Initiative promoted a surge of machine-learning studies aimed at predicting disease onset and progression.
Alex A. Nguyen +4 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
BMC NeurologyBackground Increasing evidence has highlighted the crucial role of long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) in the development and progression of Parkinson’s disease (PD). Investigating which lncRNA and mRNA biomarkers are associated with
Yixuan Wang +6 more
doaj +1 more source
Keluwih (Artocarpus camansi) extract effects in zebrafish models of Parkinson’s disease
Jurnal Teknologi Laboratorium, 2023 Parkinson’s disease is a condition that affects the central nervous system in the brain and is brought on by a lack of dopamine. Uncontrollable tremors, uncoordinated movement, and stiffness characterize Parkinson’s disease. Until now, the medication for
Marisca Evalina Gondokesumo +5 more
doaj +1 more source
Hawkins and Parkinson\u27s Move: What 1,000 churches reveal about spiritual growth (Book Review)
, 2017 A review of Hawkins, G. L., & Parkinson, C. (2011). Move: What 1,000 churches reveal about spiritual growth. Grand Rapids, MI: Zondervan. 286 pp. $18.99.
Pearson, Elizabeth
core +1 more source
Opposition diagrams for automorphisms of large spherical buildings [PDF]
, 2018 Let $\theta$ be an automorphism of a thick irreducible spherical building $\Delta$ of rank at least $3$ with no Fano plane residues. We prove that if there exist both type $J_1$ and $J_2$ simplices of $\Delta$ mapped onto opposite simplices by $\theta ...
Parkinson, J., Van Maldeghem, H.
core +3 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source