Results 21 to 30 of about 108,963 (268)
Parkinson's Disease and Parkinsonism: Neuropathology [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable associated extrapyramidal signs and symptoms, is accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal loss and reactive gliosis in the substantia nigra found at autopsy.
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Cells, 2020 Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation.
Javier Alvarez +4 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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TrialsBackground The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within the beta frequency range.
Hong-yu Zhang +16 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Dynamical Role of Pivotal Brain Regions in Parkinson Symptomatology Uncovered with Deep Learning
Brain Sciences, 2020 Background: The release of a broad, longitudinal anatomical dataset by the Parkinson’s Progression Markers Initiative promoted a surge of machine-learning studies aimed at predicting disease onset and progression.
Alex A. Nguyen +4 more
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Transcranial Sonography in Parkinson’s Disease and Parkinsonism
Neurological Sciences and Neurophysiology, 2023 ABSTRACT Background: Transcranial sonography (TCS) is a noninvasive imaging method that practices ultrasound waves to examine the brain structure changes in many neurological pathologies, including Parkinson’s disease (PD) and parkinsonism.
Seyma Eroglu Durmaz +3 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
BMC NeurologyBackground Increasing evidence has highlighted the crucial role of long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) in the development and progression of Parkinson’s disease (PD). Investigating which lncRNA and mRNA biomarkers are associated with
Yixuan Wang +6 more
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