FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Keluwih (Artocarpus camansi) extract effects in zebrafish models of Parkinson’s disease
Jurnal Teknologi Laboratorium, 2023 Parkinson’s disease is a condition that affects the central nervous system in the brain and is brought on by a lack of dopamine. Uncontrollable tremors, uncoordinated movement, and stiffness characterize Parkinson’s disease. Until now, the medication for
Marisca Evalina Gondokesumo +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
The Effect of Ethanolic The effect of ethanolic extract of Saffron (Crocus sativus L.) on improving the spatial memory parameters in the experimental models of Parkinson disease in male rats [PDF]
Journal of Advanced Biomedical Sciences, 2015 Background & Objective: The axial role of the oxidative stress in the pathophysiology of Parkinson disease has been identified. On the other hand, the learning and memory impairment in Parkinson disease has a distinguished outlook.
Homeyra Hatami, Gholamreza Dehghan
doaj
Thai national guideline for nuclear medicine investigation in movement disorders: Nuclear medicine society of Thailand, the neurological society of Thailand, and Thai medical physicist society collaboration [PDF]
Asia Oceania Journal of Nuclear Medicine and BiologyMovement disorders are chronic neurological syndromes with both treatable and non-treatable causes. The top causes of movement disorders are Parkinson's disease and related disorders. Functional imaging investigations with Single Photon Emission Computed
Tawika Kaewchur +14 more
doaj +1 more source
Lacunes may worsen cognition but not motor function in Parkinson's disease
Brain and Behavior, 2023 Background As one of the imaging markers of cerebral small vessel disease, lacunes has received little attention. The objective of this study was to investigate the associations of lacunes, cognition and motor function in patients with Parkinson's ...
Keke Chen +10 more
doaj +1 more source
Handwriting analysis for diagnosis and prognosis of Parkinson’s disease [PDF]
, 2010 At present, there are no quantitative, objective methods for diagnosing the Parkinson disease. Existing methods of quantitative analysis by myograms suffer by inaccuracy and patient strain; electronic tablet analysis is limited to the visible drawing ...
Brause, Rüdiger W. +2 more
core
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
Scientific Reports, 2023 A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID).
Ninfa Amato +5 more
doaj +1 more source
A smart tool for the diagnosis of Parkinsonian syndrome using wireless watches [PDF]
, 2014 This work is licensed under a Creative Commons Attribution 3.0 License.Early detection and diagnosis of Parkinson disease will provide a good chance for patients to take early actions and prevent its further development.
Goll, A, Meng, H
core +2 more sources