Toward understanding ambulatory activity decline in Parkinson disease [PDF]
, 2015 BACKGROUND: Declining ambulatory activity represents an important facet of disablement in Parkinson disease (PD). OBJECTIVE: The primary study aim was to compare the 2-year trajectory of ambulatory activity decline with concurrently evolving facets of ...
Cavanaugh, James T. +5 more
core +1 more source
The mPower Study, Parkinson Disease Mobile Data Collected Using Researchkit [PDF]
, 2016 Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide meaningful feedback to individuals.
Abhishek Pratap +11 more
core +1 more source
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
Neurobiology of Disease, 2008 The ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important cellular mechanisms for protein degradation.
Tianhong Pan +5 more
doaj +1 more source
Exploring the Association Between Rosacea and Parkinson Disease:A Danish Nationwide Cohort Study [PDF]
, 2016 Importance: The pathogenesis of rosacea is unclear, but increased matrix metalloproteinase target tissue activity appears to play an important role. Parkinson disease and other neurodegenerative disorders also display increased matrix metalloproteinase ...
Egeberg, Alexander +3 more
core +1 more source
DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease [PDF]
, 2012 DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not ...
Cain, Kevin C +14 more
core +2 more sources
Frontiers in Neurology, 2018 BackgroundAlthough bedrooms are identified as a major location for accidents among Parkinson’s disease (PD) patients, there are no studies that specifically evaluate the bedroom environments of PD patients.ObjectiveTo examine the physical bedroom ...
Roongroj Bhidayasiri +11 more
doaj +1 more source
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]
, 2016 Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio +15 more
core +5 more sources
Two-year trajectory of fall risk in people with Parkinson disease: a latent class analysis [PDF]
, 2016 Published in final edited form as: Arch Phys Med Rehabil. 2016 March ; 97(3): 372–379.e1. doi:10.1016/j.apmr.2015.10.105.OBJECTIVE: To examine fall risk trajectories occurring naturally in a sample of individuals with early to middle stage Parkinson ...
Cavanaugh, James T. +8 more
core +1 more source
Parkinson's Disease, 2015 Balance dysfunction (BD) in Parkinson’s disease (PD) is a disabling symptom, difficult to treat and predisposing to falls. The dopaminergic drugs or deep brain stimulation does not always provide significant improvements of BD and rehabilitative ...
Davide Ferrazzoli +7 more
doaj +1 more source
How to spot ocular abnormalities in progressive supranuclear palsy? A practical review
Translational Neurodegeneration, 2019 Background For parkinsonian disorders, progressive supranuclear palsy (PSP) continues to be significant for differential diagnosis. PSP presents a range of ocular abnormalities that have been suggested as optional tools for its early detection, apart ...
Onanong Phokaewvarangkul +1 more
doaj +1 more source