External validation of a simple clinical tool used to predict falls in people with Parkinson disease [PDF]
, 2015 Published in final edited form as: Parkinsonism Relat Disord. 2015 August ; 21(8): 960–963. doi:10.1016/j.parkreldis.2015.05.008.BACKGROUND: Assessment of fall risk in an individual with Parkinson disease (PD) is a critical yet often time consuming ...
Canning, Colleen G. +10 more
core +1 more source
Intravitreal Anti-VEGF Drugs and Signals of Dementia and Parkinson-Like Events: Analysis of the VigiBase Database of Spontaneous Reports [PDF]
, 2020 Introduction: Since vascular endothelial growth factor (VEGF) regulates several aspects of the central nervous system, particularly in dopaminergic neurons, VEGF inhibitors may be linked to Parkinson-like events and dementia, or variants of these ...
Avery +30 more
core +4 more sources
Toward understanding ambulatory activity decline in Parkinson disease [PDF]
, 2015 BACKGROUND: Declining ambulatory activity represents an important facet of disablement in Parkinson disease (PD). OBJECTIVE: The primary study aim was to compare the 2-year trajectory of ambulatory activity decline with concurrently evolving facets of ...
Cavanaugh, James T. +5 more
core +1 more source
The mPower Study, Parkinson Disease Mobile Data Collected Using Researchkit [PDF]
, 2016 Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide meaningful feedback to individuals.
Abhishek Pratap +11 more
core +1 more source
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
Neurobiology of Disease, 2008 The ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important cellular mechanisms for protein degradation.
Tianhong Pan +5 more
doaj +1 more source
DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease [PDF]
, 2012 DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not ...
Cain, Kevin C +14 more
core +2 more sources
Animal Models of Parkinson’s Disease
The Hidden Life of the Basal Ganglia, 2021 Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, the consequent dopamine deficit in the striatum and the accumulation of aggregated α‐ synuclein (α ...
I. T. Damas +2 more
semanticscholar +1 more source
Exploring the Association Between Rosacea and Parkinson Disease:A Danish Nationwide Cohort Study [PDF]
, 2016 Importance: The pathogenesis of rosacea is unclear, but increased matrix metalloproteinase target tissue activity appears to play an important role. Parkinson disease and other neurodegenerative disorders also display increased matrix metalloproteinase ...
Egeberg, Alexander +3 more
core +1 more source
Frontiers in Neurology, 2018 BackgroundAlthough bedrooms are identified as a major location for accidents among Parkinson’s disease (PD) patients, there are no studies that specifically evaluate the bedroom environments of PD patients.ObjectiveTo examine the physical bedroom ...
Roongroj Bhidayasiri +11 more
doaj +1 more source
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]
, 2016 Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio +15 more
core +5 more sources