Results 21 to 30 of about 9,346,254 (401)
Superoxide Dismutase (SOD)-mimetic M40403 is protective in cell and fly models of paraquat toxicity: Implications for Parkinson disease [PDF]
, 2016 Parkinson disease is a debilitating and incurable neurodegenerative disorder affecting 3c1-2% of people over 65 years of age. Oxidative damage is considered to play a central role in the progression of Parkinson disease and strong evidence links chronic
Beltramini, Mariano +8 more
core +1 more source
Animal Models of Parkinson’s Disease
The Hidden Life of the Basal Ganglia, 2021 Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, the consequent dopamine deficit in the striatum and the accumulation of aggregated α‐ synuclein (α ...
I. T. Damas +2 more
semanticscholar +1 more source
External validation of a simple clinical tool used to predict falls in people with Parkinson disease [PDF]
, 2015 Published in final edited form as: Parkinsonism Relat Disord. 2015 August ; 21(8): 960–963. doi:10.1016/j.parkreldis.2015.05.008.BACKGROUND: Assessment of fall risk in an individual with Parkinson disease (PD) is a critical yet often time consuming ...
Canning, Colleen G. +10 more
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Reversing Parkinson Disease Model with in situ Converted Nigral Neurons
Nature, 2020 Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson’s disease.
Hao Qian +14 more
semanticscholar +1 more source
The mPower Study, Parkinson Disease Mobile Data Collected Using Researchkit [PDF]
, 2016 Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide meaningful feedback to individuals.
Abhishek Pratap +11 more
core +1 more source
Toward understanding ambulatory activity decline in Parkinson disease [PDF]
, 2015 BACKGROUND: Declining ambulatory activity represents an important facet of disablement in Parkinson disease (PD). OBJECTIVE: The primary study aim was to compare the 2-year trajectory of ambulatory activity decline with concurrently evolving facets of ...
Cavanaugh, James T. +5 more
core +1 more source
Parkinson’s Disease and Autophagy [PDF]
Parkinson's Disease, 2012 It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated. In neurons, failure of autophagy may result in the accumulation of aggregate-prone proteins and subsequent neurodegeneration.
Ana María Sánchez-Pérez +5 more
openaire +5 more sources
Two-year trajectory of fall risk in people with Parkinson disease: a latent class analysis [PDF]
, 2016 Published in final edited form as: Arch Phys Med Rehabil. 2016 March ; 97(3): 372–379.e1. doi:10.1016/j.apmr.2015.10.105.OBJECTIVE: To examine fall risk trajectories occurring naturally in a sample of individuals with early to middle stage Parkinson ...
Cavanaugh, James T. +8 more
core +1 more source
The heterogeneity of Parkinson’s disease
Journal of Neural Transmission, 2023 AbstractThe heterogeneity of Parkinson’s disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research projects and therapeutic trail design.
Ullrich Wüllner +7 more
openaire +4 more sources
Acta clinica Croatica, 2009 Enteropathogenesis and clinical picture of PD- minireview.
Demarin, Vida +6 more
openaire +5 more sources