Results 71 to 80 of about 9,346,254 (401)

Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.

PLoS Biology, 2018
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the
Farah H Bardai, Dalila G Ordonez, Rachel M Bailey, Matthew Hamm, Jada Lewis, Mel B Feany   +5 more
doaj   +1 more source

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

Translational Neurodegeneration, 2019
Background IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without ...
Franziska Hopfner, Stefanie H. Müller, Dagmar Steppat, Joanna Miller, Nele Schmidt, Klaus-Peter Wandinger, Frank Leypoldt, Daniela Berg, Andre Franke, Wolfgang Lieb, Lukas Tittmann, Monika Balzer-Geldsetzer, Simon Baudrexel, Richard Dodel, Ruediger Hilker-Roggendorf, Elke Kalbe, Jan Kassubek, Thomas Klockgether, Inga Liepelt-Scarfone, Brit Mollenhauer, Petra Neuser, Kathrin Reetz, Oliver Riedel, Claudia Schulte, Jörg B. Schulz, Annika Spottke, Alexander Storch, Claudia Trenkwalder, Hans-Ulrich Wittchen, Karsten Witt, Ullrich Wüllner, Günther Deuschl, Gregor Kuhlenbäumer   +32 more
doaj   +1 more source

Handwriting analysis for diagnosis and prognosis of Parkinson’s disease [PDF]

, 2010
At present, there are no quantitative, objective methods for diagnosing the Parkinson disease. Existing methods of quantitative analysis by myograms suffer by inaccuracy and patient strain; electronic tablet analysis is limited to the visible drawing ...
Brause, Rüdiger W., Krakow, Karsten, Ünlü, Atilla   +2 more
core  

Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data. [PDF]

, 2016
BACKGROUND: Parkinson's disease has been reported in a small number of patients with chromosome 22q11.2 deletion syndrome. In this study, we screened a series of large, independent Parkinson's disease case-control studies for deletions at 22q11.2 ...
Abramov, Andrey Y, Barker, Roger A, Berendse, Henk W, Brice, Alexis, Brockmann, Kathrin, Chester, Lucy, Clarke, Carl E, Cormier, Florence, Corvol, Jean-Christophe, Doherty, Karen M, Escott-Price, Valentina, Foltynie, Thomas, Gasser, Thomas, Hardy, John, Heutink, Peter, International Parkinson's Disease Genomics Consortium (IPDGC), Lees, Andrew J, Lesage, Suzanne, Limousin, Patricia, Lubbe, Steven J, Mantripragada, Kiran, Mencacci, Niccolo E, Mok, Kin Y, Morris, Huw R, Morrison, Karen E, Nalls, Mike A, Noyce, Alastair J, Plagnol, Vincent, Salaka, Afnan, Sawcer, Stephen, Schulte, Claudia, Sheerin, Una, Simón-Sánchez, Javier, Singleton, Andrew B, van Dijk, Karin D, Warner, Tom T, Williams, Nigel M, Williams-Gray, Caroline H, Wood, Nicholas W   +38 more
core   +3 more sources

Coffee Consumption Is Associated With Later Age‐at‐Onset of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Observation studies suggest that coffee consumption may lower the risk and delay the age‐at‐onset (AAO) of Parkinson's disease (PD). The aim of this study was to explore the causal relationship and genetic association between coffee consumption and the AAO, risk, and progression of PD. Using Mendelian randomization, we identified a significant
Dariia Kuzovenkova, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +3 more
wiley   +1 more source

Feasibility of a Pharmabuddy Care Service for patients with Parkinson’s disease

BMC Health Services Research
Background Pharmaceutical care for patients with Parkinson’s disease (PD) is complex. Specialized pharmaceutical care provided by a dedicated pharmacy team member (pharmabuddy) for these patients may reduce medication-related problems. The feasibility of
C. C. M. Stuijt, F. Karapinar-Çarkit, C. van de Steeg – van Gompel, T. van Laar, B. J. F. van den Bemt, M. Heringa   +5 more
doaj   +1 more source

Inhibition of Protease-Activated Receptor-2 Activation in Parkinson’s Disease Using 1-Piperidin Propionic Acid

Biomedicines
In Parkinson’s disease, neuroinflammation is a double-edged sword; when inflammation occurs it can have harmful effects, despite its important role in battling infections and healing tissue.
Santina Quarta, Michele Sandre, Mariagrazia Ruvoletto, Marta Campagnolo, Aron Emmi, Alessandra Biasiolo, Patrizia Pontisso, Angelo Antonini   +7 more
doaj   +1 more source

Precision‐Optimised Post‐Stroke Prognoses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error metrics across samples of patients whose outcomes are known.
Thomas M. H. Hope, Howard Bowman, Rachel M. Bruce, Alex P. Leff, Cathy J. Price   +4 more
wiley   +1 more source

Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma

Cells, 2019
Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin.
Dieter Leupold, Lukasz Szyc, Goran Stankovic, Sabrina Strobel, Hans-Ullrich Völker, Ulrike Fleck, Thomas Müller, Matthias Scholz, Peter Riederer, Camelia-Maria Monoranu   +9 more
doaj   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
wiley   +1 more source