Results 81 to 90 of about 98,362 (265)
Advanced Science, EarlyView.Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song +6 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing +18 more
wiley +1 more source
Sympathetic Neurocirculatory Failure in Parkinson Disease: Evidence for an Etiologic Role of α-Synuclein [PDF]
, 2001 David S. Goldstein +2 more
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Advanced Science, EarlyView.This work introduces an on‐chip, integrated plasmonic infrared microarray sensor that enables high‐throughput, label‐free drug screening targeting structural protein biomarkers in neurodegenerative diseases. Through ultra‐compact microwell arrays, the sensor achieves ultra‐sensitive, rapid, and multiplexed secondary structural analysis of the effect of
Deepthy Kavungal +5 more
wiley +1 more source
Microhemodynamics and Hemorheology of Parkinson Disease and Syndrome
, 1992 Toshihiro Tamai
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Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source
Parkinson's Disease and Parkinsonism in the Elderly. 2000. Edited by Jolyon Meara, William Koller. Published by Cambridge University Press. 251 pages. C$73.42 approx. [PDF]
, 2001 W. R. Wayne Martin
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Advanced Science, EarlyView.The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang +15 more
wiley +1 more source