Results 91 to 100 of about 127,921 (347)

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Challenges with the differential diagnosis of progressive supranuclear palsy and Parkinson’s disease

Анналы клинической и экспериментальной неврологии, 2017
Progressive supranuclear palsy (PSP) is a severe old-age neurodegenerativedisease that is characterized by pronouncedclinical polymorphism and has different phenotypes.
R. V. Magzhanov, Angelika I. Davletova, R. А. Ibatullin, V. F. Tunik, R. F. Idrisova, K. Z. Bakhtiyarova   +5 more
doaj   +1 more source

Parkinsons disease variant detection and disclosure: PD GENEration, a North American study. [PDF]

Variants in seven genes (LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7 and VPS35) have been formally adjudicated as causal contributors to Parkinsons disease; however, individuals with Parkinsons disease are often unaware of their genetic status since clinical ...
Lyons, Kelly E, Naito, Anna, Beck, James C, Schulze, Jeanine, Cook, Lola, Schwantes-An, Tae-Hwi, Mata, Ignacio F., Quinn, Joseph F., Carbonell, Janfreisy, Alcalay, Roy, Marder, Karen S., Strom, Samuel, Schwarzschild, Michael, Mencacci, Niccolò E., Meng, Yan, Hodges, Priscila D, Bressman, Susan, Shill, Holly A, Tropea, Thomas F, Moore, Henry, Vanegas Arroyave, Nora, Tropea, Thomas, Hodges, Priscila D., Hodges, Priscila, Lyons, Kelly E., Shill, Holly A., Quinn, Joseph, Ghosh Galvelis, Kamalini, Alcalay, Roy N., Beck, James, Shill, Holly, Marder, Karen S, Mata, Ignacio F, Wills, Anne-Marie, Strom, Samuel P., Parkinsons Fdn, Lohmann, Katja, Foroud, Tatiana, Katus, Linn, Schwarzschild, Michael A, Nance, Martha A., Verbrugge, Jennifer, Nance, Martha, Quinn, Joseph F, Alcalay, Roy N, Haq, Ihtsham, Mencacci, Niccolò E, Simuni, Tanya, Rao, Shilpa C, Cruz Vicioso, Rossy, Tropea, Thomas F., Rao, Shilpa C., Singer, Carlos, Mencacci, Niccolò, Litvan, Irene, Blauwendraat, Cornelis, Beck, James C., Fernandez, Hubert, Rao, Shilpa, Mata, Ignacio, Fernandez, Hubert H., Hall, Anne, Marder, Karen, Casaceli, Cynthia, Fernandez, Hubert H, Schwarzschild, Michael A., Lyons, Kelly, Strom, Samuel P, Nance, Martha A   +68 more
core   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Parkinson′s disease

Annals of Indian Academy of Neurology, 2011
Behari, Madhuri, Bhattacharyya, Kalyan Brata, Borgohain, Rupam, Das, Shyamal Kumar, Ghosh, Bhaskar, Kishore, Asha, Krishnan, Syam, Mridula, K Rukmini, Muthane, Uday, Pal, Pramod Kumar, Sankhla, Charulata, Shukla, Garima   +11 more
  +8 more sources

A comparison of nonmotor symptom profiles in Progressive supranuclear palsy and Parkinson’s disease

Annals of Movement Disorders
INTRODUCTION: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that affects movement, gait, balance, speech, and swallowing. Nonmotor symptoms (NMSs) are well recognized in atypical parkinsonism.
S P. Chaithra, Vikram V. Holla, Shweta Prasad, Nitish L. Kamble, Ravi Yadav, Pramod K. Pal   +5 more
doaj   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

Alpha-synuclein as a biomarker of Parkinson’s disease

Анналы клинической и экспериментальной неврологии, 2017
Parkinsons disease (PD) is a common neurodegenerative disorder.Toxic aggregation of a small presynaptic protein alpha-synucleinis considered to be the main step in the pathogenesis of PD.Today there are no suitable diagnostic tests based on ...
S. N. Pchelina
doaj   +1 more source

Science in the News - Nicotinamide Exacerbates Motor Symptoms of Parkinson\u27s Disease in Mice.

, 2018
Melão, A. (2018, October 17). Nicotinamide Exacerbates Motor Symptoms of Parkinson\u27s Disease in Mice. Retrieved November 7, 2017, from https://parkinsonsnewstoday.com/2018/10/10/nicotinamide-exacerbates-motor-symptoms-of-parkinsons-disease-in ...
Tabbaa, Layth A
core  

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Vassallo, Neville, Caruana Grech Perry, Mario   +1 more
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