Results 81 to 90 of about 127,921 (347)

Predicting progression in Parkinson's Disease using baseline and 1-Year change measures [PDF]

, 2019
Background: Improved prediction of Parkinson’s disease (PD) progression is needed to support clinical decision-making and to accelerate research trials.
Kieburtz, Karl, Mather, Joe, Mule, Jennifer, Shprecher, David, Ruiz Martinez, Javiar, Brown, Victoria, Politis, Marios, Rosenthal, Liana, Hogarth, Penelope, Barnes, Janel, Smejdir, Debra, Mintun, Mark A, Tai, Yen, Arnedo, Vanessa, Mahes, Sugi, Mollenhauer, Brit, Coffey, Christopher, Severt, Lawrence, Dahodwala, Nabila, Hillert, Gabrielle Ahlberg, Bressman, Susan, Kopil, Catherine, Wethington, Misty, Vandenbroucke, Emily, Saint-Hilaire, Marie, Siderowf, Andrew, Harrell, Leigh, Corvol, Jean-Christophe, Ribb, Kori, Facheris, Maurizio, Tolosa, Eduardo, Cedarbaum, Jesse, Dorsey, Ray, Speketer, Krista, Shaw, Leslie, Russell, David, De Santi, Susan, Willeke, Diana, Egebjerg, Jan, Isaacson, Stuart, Richard, Irene, Biglan, Kevin, Freed, Alison, Orr-Urtreger, Avi, Rowe, Dominic, Trojanowski, John, Frasier, Mark, Simuni, Tanya, Factor, Stewart, Barone, Paolo, Soares, Holly, Galasko, Douglas, Montine, Thomas, Hauser, Robert, Peacock, Shawnees, Standaert, David, Hunter, Christine, Raymond, Deborah, Taylor, Kirsten, Muglia, Pierandrea, Moreno, Juliana, Avbersek, Andreja, Casaceli, Cynthia, Crawford, Karen, Tauscher, Johannes, Salerno, Christina, Reith, Alastair, Zimmerman, Grace, Post, Anke, Carvajal, Lisbeth, Giladi, Nir, Bingol, Baris, Boess, Frank, Weisz, Mali Gani, Carvalho, Stephanie, Hu, Shu-Ching, Kausar, Farah, Sommerfeld, Barbara, Sardi, Pablo, Santana, Helen Mejia, Marek, Kenneth, Hilt, Ella, Chowdhury, Sohini, Santiago, Anthony, Grachev, Igor, Garrido, Alicia, Seedorff, Nicholas, Singleton, Andrew, Tanner, Caroline, Casalin, Paola, Brockmann, Katrina, Poewe, Werner, Viswanth, Veena, Merchant, Kaplana, Rees, Linda, Guthrie, Stephanie, Payne, Laura Marie, Jankovic, Joseph, Foroud, Tatiana, Richardson, Whitney, Saba, Barbara, Croitoru, Ioana, Sherer, Todd, Daegele, Nichole, Seibyl, John, Taylor, Peggy, Umek, Robert, Caspell-Garcia, Chelsea, Toga, Arthur, Poston, Kathleen, Ainscough, Susan, Sheikh, Zulfiqar Haider, Malferrari, Giulia, Ranola, Madelaine, Wilson, Renee, Blair, Courtney, Fischer, Tanya, Espay, Alberto, Chahine, Lana, Fernandez, Hubert, Williams, Karen, Min, Chris, James, Raymond, Wakeman, Katrina, Thomas, Cathi-Ann, Forrat, Remi, Chahine, Lana M, Tosun-Turgut, Duygu, Marder, Karen, Coffey, Christopher S   +129 more
core   +1 more source

Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson\u27s Disease [PDF]

, 2020
It was recently shown (Sampson et al., Elife9, 2020) that an amyloidogenic protein, CsgA, present in E. coli biofilms in the gut can trigger Parkinson\u27s disease in mice.
Wittung Stafshede, Pernilla, Werner, Tony,, Werner, Tony, Horvath, Istvan, Horvath, Istvan,, Wittung Stafshede, Pernilla,   +5 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Management of L-Dopa Overdose in the Competitive Inhibition State [Expression of Concern]

Drug, Healthcare and Patient Safety, 2020
Hinz M, Stein A, Cole T. Drug Healthc Patient Saf. 2014;6:93–99. The Editor-in-Chief and Publisher of Drug, Healthcare and Patient Safety wish to issue an Expression of Concern for the published article.
Hinz M, Stein A, Cole T
doaj  

Association of Tooth Loss with New-Onset Parkinson's Disease: A Nationwide Population-Based Cohort Study

, 2021
Introduction. Tooth loss is associated with poor oral hygiene. During insufficient oral sanitation, focal infection and inflammation can occur and these reactions may induce systemic inflammation.
우호걸, 장윤경, 송태진
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Management of L-Dopa Overdose in the Competitive Inhibition State [Retraction]

Drug, Healthcare and Patient Safety, 2020
Hinz M, Stein A, Cole T. Drug Healthc Patient Saf.  2014;6:93— 99. The Editor-in-chief and Publisher of Drug, Healthcare and Patient Safety wish to retract the published article.
Hinz M, Stein A, Cole T
doaj  

Clinical Non-Motor Phenotyping of Black and Asian Minority Ethnic Compared to White Individuals with Parkinson's Disease Living in the United Kingdom [PDF]

, 2020
BACKGROUND: Ethnic phenotypic differences in Parkinson's disease (PD) are important to understand the heterogeneity of PD and develop biomarkers and clinical trials. OBJECTIVE: To investigate (i) whether there are non-motor symptoms (NMS)-and comorbidity-
Siakallis, L, Corcoran, B, Rizos, A, Jarosz, J, Aarsland, D, Vivian, G, Sauerbier, A, Ray Chaudhuri, K, Dafsari, HS, Aarsland, D,, Brown, R, Schrag, A, Mulholland, N, Martinez-Martin, P   +13 more
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Odor Recognition Memory in Parkinsons Disease : A Systematic Review

, 2021
Olfactory impairment is a central non-motor symptom in Parkinsons disease (PD). Previous studies have demonstrated that olfactory dysfunction is associated with mental illness and impaired cognition.
Eek, Tom,, Eek, Tom, Larsson, Maria,, Dizdar Segrell, Nil,, Dizdar, Nil   +4 more
core   +1 more source