Results 71 to 80 of about 39,514 (227)

Management of Widespread Pain and Fibromyalgia [PDF]

, 2016
Peer reviewedPublisher ...
Basu, Neil, Dean, Linda E, Whibley, Daniel   +2 more
core   +2 more sources

Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication

Frontiers in Pharmacology
ObjectiveThe cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.
Alena Damborská, Alena Damborská, Lenka Hanáková, Eva Pindurová, Eva Pindurová, Kateřina Horská, Kateřina Horská   +6 more
doaj   +1 more source

Comparison of paroxetine and dapoxetine, a novel selective serotonin reuptake inhibitor in the treatment of premature ejaculation

Asian Journal of Andrology, 2014
Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor and the first drug approved for the on-demand treatment of premature ejaculation (PE). Our objective in this study was to characterize the efficacy of on-demand dapoxetine (30 and 60 mg)
Abdulmuttalip Simsek, Sinan Levent Kirecci, Onur Kucuktopcu, Faruk Ozgor, Mehmet Fatih Akbulut, Omer Sarilar, Unsal Ozkuvanci, Zafer Gokhan Gurbuz   +7 more
doaj   +1 more source

Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: Possible association but no influence of personality disorders [PDF]

, 2001
Objective: Impulsive behavior in alcoholics puts them at serious risk of severer course of disease and has been related to the serotonergic neurotransmission dysfunction.
Bahlmann, Miriam, Bondy, Brigitta, Koller, G., Preuss, Ulrich W., Soyka, Michael   +4 more
core   +1 more source

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing. However, substantial variation exists between scales, with no gold standard identified.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
wiley   +1 more source

A novel role of the antidepressant paroxetine in inhibiting neuronal Kv7/M channels to enhance neuronal excitability

Translational Psychiatry
The voltage-gated Kv7/KCNQ/M potassium channels exert inhibitory control over neuronal membrane excitability. The reduction of Kv7 channel function can improve neuronal excitability that defines the fundamental mechanism of learning and memory.
Huan Shi, Qinqin Li, Fang Hu, Yani Liu, KeWei Wang   +4 more
doaj   +1 more source

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. [PDF]

, 2013
In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD).
Bogdanov, MB, Boyle, SH, Churchill, E, Delnomdedieu, M, Fiehn, O, Kaddurah-Daouk, R, Krishnan, RR, Pickering, E, Rush, AJ, Wang, Z, Wikoff, WR, Zhu, H   +11 more
core   +2 more sources

Neuroticism, Internalizing Psychopathology, and Affective Reactions to Thought Content in Daily Life

Journal of Personality, EarlyView.
ABSTRACT Introduction This study examined affective reactions to thought content (TC) in daily life and the influence of neuroticism and internalizing symptoms. Methods Community young adults (N = 119; n = 80 with elevated depression/anxiety) completed assessments of neuroticism, internalizing symptoms, and daily diary measures of TC and positive ...
Henry R. Cowan, Aidan G. C. Wright, Sarah L. Pedersen, Dahlia Mukherjee, Sophie Lazarus, Jay C. Fournier   +5 more
wiley   +1 more source

Psychogenic polydipsia in dogs – a review of pathogenesis, diagnosis and treatment

Journal of Small Animal Practice, EarlyView.
Polyuria and polydipsia represent a common clinical presentation in dogs and may result from numerous disorders affecting different body systems. Compulsive water consumption is characteristic of psychogenic polydipsia, a primary polydipsia disorder rooted in neurologic, behavioural or environmental factors.
G. Pavlovsky
wiley   +1 more source

Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]

, 2017
BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
core