Results 71 to 80 of about 15,613 (254)

Human Protein Z as the Second Known Heme‐Binding Protein from the Endogenous Blood Coagulation Inhibitor System

ChemBioChem, Volume 27, Issue 1, January 2026.
Protein Z is a vitamin K‐dependent anticoagulant with elusive molecular functions. Herein, it is shown that heme binds to protein Z and induces conformational changes. One histidine‐based heme‐binding motif is identified. High heme‐binding affinity and functional effects are demonstrated on protein level. These findings shed new light on the structural
Paula Lindemann, Marie‐T. Hopp
wiley   +1 more source

Off-Pump Coronary Revascularization Using Bilateral Internal Thoracic Arteries in A Patient with Paroxysmal Nocturnal Hemoglobinuria: A Case Report

Brazilian Journal of Cardiovascular Surgery
Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-orphan disease. We report the first case in the literature of Off-Pump Coronary Revascularization Using Bilateral Internal Thoracic Arteries in a patient with paroxysmal nocturnal hemoglobinuria. A 36-
Juan Mariano Vrancic, Manuel Roque Cervetti, Julián Benavides, Daniel Navia   +3 more
doaj   +1 more source

Immune‐Mediated Thrombocytopenia in an Ulcerative Colitis Patient After Initiating Filgotinib Treatment: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Timeline of events ABSTRACT Moderate‐to‐severe ulcerative colitis can be effectively treated with JAK‐1 inhibition, but platelet counts should be closely monitored, especially in active disease. We confirmed immune‐mediated thrombocytopenia (ITP) in one of our patients after the initiation of filgotinib. Whether this was drug‐induced is uncertain.
M. J. van der Hoff, F. El‐Morabit, M. Löwenberg   +2 more
wiley   +1 more source

Increased Circulating Soluble Cd14 Is Associated With High Mortality In Gram-Negative Septic Shock [PDF]

, 2017
The soluble glycoprotein sCD14 binds lipopolysaccharide, a complex that activates endothelial cells and that may be crucial in gram-negative sepsis, Therefore, serum sCD14 was analyzed in 54 patients with gram-negative septic shock and in 26 healthy ...
Calandra, Thierry, Glauser, Michel Pierre, Hahn, Alfred, Landmann, Regine, Link, Susanne, Sansano, Sebastiano, Zimmerli, Werner   +6 more
core  

MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
1. PNH patients lack the complement regulatory proteins CD55 and CD59, triggering excessive activation of the terminal complement pathway and a prothrombotic state. 2. MUC4 mutation is an independent thrombotic risk factor in PNH. 3. Mutation/down‐regulation of MUC4 promotes the abnormal deposition of excessively activated terminal complement ...
Yingying Chen, Mengting Che, Chaomeng Wang, Qiaoyi Bronte Zhang, Weixin Chen, Hui Liu, Chunyan Liu, Guang Sheng Ling, Rong Fu   +8 more
wiley   +1 more source

Clinical studies on iron metabolism of erythroblasts in preleukemic stage [PDF]

, 1974
The appearance of sideroblasts in hypoplastic anemia (HAl and acute myelocytic leukemia (AML), together with their sideroblastograms, was studied. Hematological studies on cases with type III sideroblast dominance by sideroblastograms produced the ...
Kimura, Ikuro, Sugiyama, Motoharu, Takahashi, lsao   +2 more
core   +1 more source

Improvement in survival of patients with higher risk but not lower risk myelodysplastic syndromes over 20 years: A retrospective study from Nagasaki, Japan

British Journal of Haematology, EarlyView.
Takafumi Furumoto, Koji Ando, Eo Toriyama, Tomoko Hata, Hikaru Sakamoto, Masahiko Chiwata, Hideaki Kitanosono, Jun Nakashima, Takeharu Kato, Masataka Taguchi, Makiko Horai, Hidehiro Itonaga, Shinya Sato, Yasushi Sawayama, Daisuke Imanishi, Yoshitaka Imaizumi, Tatsuro Jo, Shinichiro Yoshida, Yukiyoshi Moriuchi, Yasushi Miyazaki   +19 more
wiley   +1 more source

Validation of a candidate international harmonisation protocol‐compliant measurement procedure for reticulocyte counting using an erythrocyte gating strategy excluding the platelet component

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 1, Page 47-56, January 2026.
Abstract The International Harmonisation Protocol (IHP) for Reticulocyte Percentage (%Retic) in CLSI‐H44‐A2 is a microscopic procedure performed on a new‐methylene‐blue‐stained blood film (NMB‐IHP). However, IHP‐compliant Measurement Procedures (MPs) based on flow cytometry (FCM) are recommended for practical and accurately assigned reference values ...
Yutaka Nagai, Tomohiro Takeda, Hiromichi Matsushita, Tomoko Arai, Yoko Yatabe, Hiromitsu Yokota, Takayuki Mitsuhashi, Masatoshi Wakui, Yohko Kawai, Hiroshi Kondo   +9 more
wiley   +1 more source

Left-Sided Portal Hypertension: a Case Series [PDF]

, 2018
Left-sided portal hypertension is rarely found, but this condition may cause gastrointestinal tract bleeding and can be life-threatening. The exact incidence of left-sided portal hypertension is unknown as it is rarely found, approximately 1-5%, and most
Agustanti, N. (Nenny), Andini, D. (Dinda), Darmawan, G. (Guntur)   +2 more
core  

A De Novo Splicing Mutation of SRP72 in Bone Marrow Failure Syndrome Type 1: Case Report and Review of the Literature

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study reports a rare case of bone marrow failure syndrome type 1 (BMFS1) caused by a novel de novo splicing mutation (c.1502+1G>A) in the SRP72 gene. The 6‐year‐old patient presented with aplastic anemia and pancytopenia. Genetic analysis identified the mutation, which was absent in both parents, confirming its de novo origin.
Wang Xiangwen, Zhang Duo, Hao Wenjing, Hou Hui   +3 more
wiley   +1 more source