Results 121 to 130 of about 116,902 (309)

Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging

EJNMMI Radiopharmacy and Chemistry
Background Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a promising class of therapeutics, particularly in the treatment of cancers with defective DNA repair mechanisms, such as those with breast cancer genes (BRCA) mutations.
Gianluca Destro, Rebecca Rizzo, Chiara Rua, Raha Rouhbakhsh Azimi, Silvia Morbelli   +4 more
doaj   +1 more source

A poli(ADP-ribóz) polimeráz 2 (PARP-2) metabolizmusban betöltött szerepe HepG2 sejtekben

, 2011
A poli(ADP)-ribóz polimeráz 2 (PARP-2) egy a 17 eddig felfedezett PARP enzim közül, melyekhez sok biológiai szerep rendelhető, mint például a DNS hibajavítás, spermatogenezis, gyulladásos folyamatok, metabolizmus.
Hollós, Patrik
core  

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

A PARP inhibitorok hatásának vizsgálata humán keratinociták differenciációjára

A poli(ADP-riboz)iláció egy poszttranszlációs fehérje módosítás, amelyet a poli(ADP-ribóz) polimeráz (PARP) enzimek végeznek. A PARP aktivitás számos biológiai folyamat szabályozásában szerepel, többek között a DNS hibajavítás, transzkripció és ...
Maczkó, Eszter
core  

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

Mono-methylated histones control PARP-1 in chromatin and transcription

eLife
PARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks ...
Gbolahan Bamgbose, Guillaume Bordet, Niraj Lodhi, Alexei Tulin   +3 more
doaj   +1 more source

Incorporating PARP Inhibition in Cancer Therapy: Key Questions, Expert Answers

, 2015
This engaging symposium focussed on the rationale and current evidence supporting the role for poly(adenosine diphosphate-ribose) polymerase (PARP) inhibition in patients with cancer.
Eric Van Cutsem, Hilary Calvert, Andrew Tutt, Tristin Abair, Nicoletta Colombo, Eric Pujade-Lauraine   +5 more
core  

PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting

, 2017
Poly(ADP-ribose) polymerases have shown true promise in early clinical studies due to reported activity in BRCA-associated cancers. PARP inhibitors may represent a potentially important new class of chemotherapeutic agents directed at targeting cancers ...
Karolina N. Dziadkowiec, Anna Jankowska, Ewa Nowak-Markwitz, Emilia Gąsiorowska   +3 more
core   +1 more source

Aloe vera in Food Preservation: Harnessing Bioactive Constituents for Clean‐Label Innovation and Safety Assurance

Food Safety and Health, EarlyView.
Aloe vera‐derived biopolymers and nanoformulations enhance antimicrobial, antioxidant, and barrier functions in clean‐label edible coatings and films, whereas safety‐critical anthraquinone thresholds and regulatory constraints shape their translational potential.
Acharya Balkrishna, Hemant Sharma, Sonam Verma, Amar Jeet, Sumit Kumar Singh, Sharad Kumar Tripathi, Vedpriya Arya   +6 more
wiley   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source