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MOB2 Loss Sensitizes Lung Cancer Cells to PARP Inhibition Through p53-Dependent DNA Damage Signaling. [PDF]
Curr Issues Mol BiolGundogdu R.
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The first and second zinc finger domains from Poly-ADP-ribose polymerase 1 (PARP1) are modified by hydrogen sulfide. [PDF]
J Biol Inorg ChemWilliams AJ, Michel SLJ.
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Plant PARPs, PARGs and PARP-like Proteins
Current Protein & Peptide Science, 2016Poly(ADP-ribos)ylation, originally described as a mechanism of DNA break repair, is now considered as part of a complex regulatory system involved in dynamic reorganization of chromatin structure, transcriptional control of gene expression and regulation of metabolism. In plants poly(ADP-ribos)ylation has received surprisingly little attention.
Julia P, Vainonen +3 more
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BioEssays, 2004
AbstractPoly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP‐ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic ...
Amé, Jean-Christophe +2 more
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AbstractPoly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP‐ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic ...
Amé, Jean-Christophe +2 more
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Pharmacological Research, 2005
Poly(ADP-ribosyl)ation, which is the posttranslational modification of proteins with poly(ADP-ribose), is catalysed by poly(ADP-ribose) polymerases. DNA-strand break induced catalytic activation of two PARP isoforms, namely PARP-1 and -2, are in involved in DNA base-excision repair and other repair pathways.
Alexander, Bürkle +3 more
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Poly(ADP-ribosyl)ation, which is the posttranslational modification of proteins with poly(ADP-ribose), is catalysed by poly(ADP-ribose) polymerases. DNA-strand break induced catalytic activation of two PARP isoforms, namely PARP-1 and -2, are in involved in DNA base-excision repair and other repair pathways.
Alexander, Bürkle +3 more
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2014
© Springer Science+Business Media New York 2017. All rights reserved. PARP enzymes synthese poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD+) as a substrate. PARP-1 is the most extensively studied of a family of PARP enzymes. It is a highly abundant nuclear protein that is activated by DNA breaks and facilitates their repair.
Patterson MJ, Drew Y, Curtin NJ
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© Springer Science+Business Media New York 2017. All rights reserved. PARP enzymes synthese poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD+) as a substrate. PARP-1 is the most extensively studied of a family of PARP enzymes. It is a highly abundant nuclear protein that is activated by DNA breaks and facilitates their repair.
Patterson MJ, Drew Y, Curtin NJ
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The Vasoactivity of PARP Inhibitors
2015PARP-inhibition has proven to be an attractive therapeutic approach in cancer whereby the effectiveness of DNA-damaging therapy can be enhanced by inhibiting the PARP-mediated DNA-repair process. Generally there is good concordance between enhanced therapeutic efficacy in vitro and that observed in vivo.
Williams, Kaye J., McCrudden, Cian M.
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Trends in Biochemical Sciences, 2001
An immediate cellular response to DNA damage is the synthesis of poly(ADP-ribose) by the enzyme poly(ADP-ribose) polymerase (PARP). This nuclear enzyme and the unique post-translational modification it catalyzes have long been considered to function exclusively in cellular surveillance of genotoxic stress.
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An immediate cellular response to DNA damage is the synthesis of poly(ADP-ribose) by the enzyme poly(ADP-ribose) polymerase (PARP). This nuclear enzyme and the unique post-translational modification it catalyzes have long been considered to function exclusively in cellular surveillance of genotoxic stress.
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Pharmacological Research, 2005
The activation of poly(ADP-ribose) polymerase (PARP) is well considered to play an important role in various patho-physiological conditions like inflammation and shock. A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially, superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as ...
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The activation of poly(ADP-ribose) polymerase (PARP) is well considered to play an important role in various patho-physiological conditions like inflammation and shock. A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially, superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as ...
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PARP trapping is governed by the PARP inhibitor dissociation rate constant
Cell Chemical BiologyPoly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are a class of cancer drugs that enzymatically inhibit PARP activity at sites of DNA damage. Yet, PARPi function mainly by trapping PARP1 onto DNA with a wide range of potency among the clinically relevant inhibitors. How PARPi trap and why some are better trappers remain unknown.
Angelica A, Gopal +4 more
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