Results 111 to 120 of about 116,902 (309)

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

BMC Cell Biology, 2008
Background The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlled by protein-protein interactions.
Valovka Taras, Hassa Paul O, Altmeyer Matthias, Haenni Sandra S, Fey Monika, Hottiger Michael O   +5 more
doaj   +1 more source

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter

, 2012
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
Babich, J.W., Champion, S., Babich, John W, Mairs, Robert J, Gaze, Mark N, Tesson, Mathias, McCluskey, Anthony G, Champion, Sue, Mairs, R.J., McCluskey, A.G., Gaze, M.N., Pimlott, S.L., Boyd, Marie, Tesson, M., Boyd, M., Pimlott, Sally L   +15 more
core   +1 more source

Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1-4

, 2011
Copyright information:Taken from "Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1"http://www.biomedcentral.com/1471-2199/8/96BMC Molecular Biology
Sylvain L Guérin (83633), Serge Desnoyers (83632), Steeve Leclerc (22751), Karine Zaniolo (83631)   +3 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

A poli(ADP-ribóz) polimeráz-1 (PARP-1) és a poli(ADP-ribóz) glikohidroláz (PARG) enzim géncsendesítésének vizsgálata A549 sejtekben

, 2010
A poli(ADP-ribóz) polimeráz-1 (PARP-1) és a poli(ADP-ribóz) glikohidroláz (PARG) enzim géncsendesítésének vizsgálata RNS tisztítással,western blottal,agaróz gélelektroforézissel, immuncitokémiával A549 sejtekben.gjBiológiai laboratóriumi ...
Czakó, Nikoletta
core  

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

, 2006
International audienceParp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or nonhomologous
Mitsuko Masutani (78971), Hideki Koyama (264892), Schreiber, Valérie, Masutani, Mitsuko, Zhao, Guang Yu, Eiichiro Sonoda (10497), Takeda, Shunichi, Alihossein Saberi (513593), Morrison, Ciaran, Valérie Schreiber (16108166), Shunichi Takeda (10500), Murcia, Gilbert,, Ciaran Morrison (16108163), Gilbert de Murcia (13387), Saberi, Alihossein, Guang Yu Zhao (14883864), Donniphat Dejsuphong (213718), Murcia, Gilbert, De, Fukushima, Toru, Dejsuphong, Donniphat, Toru Fukushima (14874014), Adachi, Noritaka, Hochegger, Helfrid, Sonoda, Eiichiro, Koyama, Hideki, Helfrid Hochegger (4462252), de Murcia, Gilbert, Noritaka Adachi (180284)   +27 more
core   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

Mediators of Inflammation, 2015
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory ...
Samuel García, Carmen Conde
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source