Results 221 to 230 of about 116,902 (309)

Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1 inhibition. [PDF]

PLoS One
Chapman IG, Wu X, Veuger S, Jowsey PA.
europepmc   +1 more source

Pyruvate Kinase M2 Mediates Apigenin‐Induced Energy Crisis and Apoptosis in Colon Cancer Cells

Food Frontiers, Volume 7, Issue 4, July 2026.
Apigenin, a dietary flavonoid with low toxicity, induces profound bioenergetic collapse in colon cancer cells by downregulating PKM2. This metabolic crisis, characterized by suppressed glycolysis and mitochondrial dysfunction, ultimately triggers robust apoptosis.
Ke Zhang, Xingtao Zhou, Xujie Wang, Mingyong Xie   +3 more
wiley   +1 more source

<i>DDERMMAL</i>, a melanocytic long non-coding RNA, confers DNA damage tolerance to melanoma cells. [PDF]

iScience
Adnane S, Verheyden Y, Cuomo A, Bonaldi T, Leucci E.   +4 more
europepmc   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

PARP Inhibitors and the Risk of Serum Creatinine Elevation in Ovarian Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Cancers (Basel)
Gąsowska-Bodnar A, Gąsowska-Bajger B, Żołnierek A, Żołnierek J, Bodnar L.   +4 more
europepmc   +1 more source

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li, Binfan He, Mengmeng Hao, Ye Liu, Shunxin Song, Rongzhang He   +5 more
wiley   +1 more source

Durable complete remission of pulmonary metastases with bevacizumab plus olaparib maintenance therapy in homologous recombination-deficient gynecologic large-cell neuroendocrine carcinoma: A case report. [PDF]

Gynecol Oncol Rep
Iida Y, Saito Y, Shimazaki M, Ichikawa T, Irie T, Matsushima J, Iizuka M, Takakura S.   +7 more
europepmc   +1 more source

Lessons From Astaxanthin Therapy to Combat Oral Premalignant and Malignant Lesions: A Narrative Review

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Oral cancer is one of the most common head and neck malignancies and remains associated with high morbidity, mortality, and treatment‐related toxicity. Despite advances in surgery, radiotherapy, and chemotherapy, there is still a need for safer adjunctive therapies with better therapeutic potential.
Reza Arefnezhad, Zhina Mohamadi, Shervin Shahianjahromi, Amirali Fallahian, Maryam Ashrafi, Armin Nikdehqan, Mitra Saeedi Valashani, Reza Nasiri, Fatemeh Zeinali, Hossein Fatemian, Niloofar Sefati, Fatemeh Rezaei‐Tazangi, Marziye Ranjbar Tavakoli   +12 more
wiley   +1 more source

Inactivation of PRMT5 by PARP Inhibitors Confers High Susceptibility in MTAP-Deficient Cancers. [PDF]

Cancers (Basel)
Liu Q, Sheng Y, Lin F, Tan H, Chang Y, Lu X, Chen H, Du C.   +7 more
europepmc   +1 more source