Results 81 to 90 of about 116,902 (309)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population

Tumor Biology, 2017
PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang ...
Jiatong Li, Dongwei Dou, Ping Li, Wenqi Luo, Wenxin Lv, Chengdong Zhang, Xiaowei Song, Yuan Yang, Yuening Zhang, Yanzhen Xu, Feifan Xiao, Yan Wei, Jian Qin, Hongtao Li, Xiaoli Yang   +14 more
doaj   +1 more source

Poly(ADP-ribose) Polymerase-1 in the Nervous System

Neurobiology of Disease, 2000
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme, activated by DNA strand breaks to participate in DNA repair. Overactivation of PARP by cellular insults depletes its substrate NAD+ and then ATP, leading to a major energy deficit and cell death.
Hyo Chol Ha, Solomon H. Snyder
doaj   +1 more source

Poly(ADP-Ribose) Polymerase (PARP) signaling of DNA damage induced by Topoisomerase 1 (TOP1) inhibition in carcinoma cells: chemotherapeutic implications of PARP and TOP1 inhibitors.

, 2010
Una nuova strategia molecolare che incrementa l’azione antitumorale degli inibitori della Topoisomerasi 1 (TOP1) si basa sull’utilizzo di inibitori delle poli(ADP-ribosio) polimerasi (PARP).
D'Onofrio, Giovanna
core  

Oral administration of PARP inhibitor GPI 18180 increases the anti-tumor activity of temozolomide against intracranial melanoma in mice.

, 2005
Poly(ADP-ribose) polymerase-1 (PARP) inhibitors have been investigated as enhancers of chemotherapy. We recently showed that PARP inhibitor GPI 15427 increases the anti-tumor efficacy of temozolomide (TMZ) in mice. To select a PARP inhibitor for clinical
C. Leonetti, M. Vergati, Tentori, L, J. Zhang, G. Graziani, GRAZIANI, GRAZIA, Vergati, M, TENTORI, LUCIO, M. Scarsella, Graziani, G, A. Muzi, Leonetti, C, and and the Guilford PARP Project Group, Scarsella, M, Muzi, A, Lapidus, RG, MUZI, ALESSIA, L. Tentori, R. G. Lapidus, and the Guilford PARP Project Group, Zhang, J   +20 more
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1-1

, 2011
Copyright information:Taken from "Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1"http://www.biomedcentral.com/1471-2199/8/96BMC Molecular Biology
Sylvain L Guérin (83633), Serge Desnoyers (83632), Steeve Leclerc (22751), Karine Zaniolo (83631)   +3 more
core   +1 more source

PARP inhibitors as first-line maintenance therapy in ovarian cancer: recommendations from an expert panel from Brazil

, 2023
To report consensus recommendations on the current role of poly(ADP-ribose) polymerase (PARP) inhibitors in the front-line management of patients with epithelial ovarian cancer (EOC) in the healthcare setting of Brazil. The expert panel convened in March
Angelica Nogueira-Rodrigues, Michelle Samora Almeida, Rachel Cossetti, Karime Kalil, Marcela Crosara, Aknar FC Calabrich, Daniele Xavier Assad, Ana Carolina Leite, Andreia C Melo, Carla Rameri de Azevedo, Andrea PG Guimarães, Alessandra Menezes Morelle, Eduardo Cronemberger, Rodrigo Guindalini, Eduardo Paulino, Graziela Dal-Molin, Daniela de Freitas, João Soares Nunes, Poliana Signorini, Fernando C Maluf   +19 more
core   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy

Angewandte Chemie, EarlyView.
A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng, Bing‐Ya Wang, Hai Xu, Qiang Wang, Rong‐Dan Xiao, Rui Tan, Yu Peng, Ya‐Wen Wang, Juyoung Yoon   +8 more
wiley   +2 more sources