Results 21 to 30 of about 47,778 (228)

Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle [PDF]

, 2018
Poly(ADP-ribosyl)ation (PAR) is a post-translational protein modification catalysed by enzyme member of the poly(ADP-ribose) polymerases (PARPs) family. The activation of several PARPs is triggered by DNA strand breakage and the main PARP enzyme involved
Buttazzoni, Luca, De Matteis, Giovanna, Grandoni, Francesco, Meyer, Ralph G., Meyer-Ficca, Mirella L., Moioli, Bianca, Reale, Anna, Scatà, Maria Carmela   +7 more
core   +1 more source

Trial watch: STING agonists in cancer therapy

OncoImmunology, 2020
Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour, Laurence Zitvogel, Lorenzo Galluzzi, Erika Vacchelli, Guido Kroemer   +4 more
doaj   +1 more source

dUTPase based switch controls transfer of virulence genes in order to preserve integrity of the transferred mobile genetic elements [PDF]

, 2013
dUTPases ubiquitously regulate cellular dUTP levels to preserve genome integrity. Recently, several other cellular processes were reported to be controlled by dUTPases including the horizontal transfer of Staphylococcus aureus pathogenicity islands ...
Bendes, A., Besztercei, B., Leveles, I., Liliom, K., Nyíri, K., Németh-Pongrácz, V., Papp-Kádár, V., Pálinkás, H., Róna, G., Szabó, J. E., Tóth, J., Vértessy G., Beáta, Zagyva, I.   +12 more
core   +1 more source

PARP inhibition: PARP1 and beyond [PDF]

Nature Reviews Cancer, 2010
Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide ...
Michèle, Rouleau, Anand, Patel, Michael J, Hendzel, Scott H, Kaufmann, Guy G, Poirier   +4 more
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

SPINDOC binds PARP1 to facilitate PARylation [PDF]

Nature Communications, 2021
AbstractSPINDOC is tightly associated with the histone H3K4me3 effector protein SPIN1. To gain a better understanding of the biological roles of SPINDOC, we identified its interacting proteins. Unexpectedly, SPINDOC forms two mutually exclusive protein complexes, one with SPIN1 and the other with PARP1.
Fen Yang, Jianji Chen, Bin Liu, Guozhen Gao, Manu Sebastian, Collene Jeter, Jianjun Shen, Maria D. Person, Mark T. Bedford   +8 more
openaire   +3 more sources

PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]

, 2010
PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel, Ame, Anna E.O. Fisher, Audebert, Bekker-Jensen, Benjamin, Bernardo Reina-San-Martin, Boulton, Brown, Bryant, Bryant, Caldecott, Caldecott, Critchlow, Ding, Drouet, El-Khamisy, Farmer, Fisher, Grawunder, Guy Poirier, Hochegger, Hottiger, Iles, Isabelle Robert, Kanno, Keith W. Caldecott, Kickhoefer, Kleine, Le Page, Lehtio, Limei Ju, Lobrich, Loseva, Macrae, Mahaney, Maria C. Zuma, Mehrotra, Michele Rouleau, Morrison, Okano, Otto, Poirier, Robert, Roberts, Rogakou, Rogakou, Rouleau, Rulten, Smith, Soulas-Sprauel, Stevnsner, Stuart L. Rulten, Sugimura, Trucco, Wang, Yan, Yang, Yano, Yano   +59 more
core   +1 more source

A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells. [PDF]

PLoS ONE, 2016
Poly(ADP-ribose) polymerase 1 (PARP1) is a key player in DNA repair, genomic stability and cell survival and it emerges as a highly relevant target for cancer therapies.
Andrea Buchfellner, Larisa Yurlova, Stefan Nüske, Armin M Scholz, Jacqueline Bogner, Benjamin Ruf, Kourosh Zolghadr, Sophie E Drexler, Guido A Drexler, Stefanie Girst, Christoph Greubel, Judith Reindl, Christian Siebenwirth, Tina Romer, Anna A Friedl, Ulrich Rothbauer   +15 more
doaj   +1 more source

18β-Glycyrrhetinic Acid Alleviates P. multocida-Induced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells

Infection and Drug Resistance, 2023
Qirong Lu,1,* Wantong Han,1,* Defeng Wen,1,* Pu Guo,1 Yu Liu,1 Zhongyuan Wu,1 Shulin Fu,1 Chun Ye,1 Xu Wang,2 Yinsheng Qiu1 1Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering ...
Lu Q, Han W, Wen D, Guo P, Liu Y, Wu Z, Fu S, Ye C, Wang X, Qiu Y   +9 more
doaj  

Analysis of mutations of PARP1, RNF213, PAX8, KMT2C, MTRR in malignant mesothelioma of testicular tunica vaginalis testis

Polish Journal of Pathology, 2020
Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man.
Artur Kowalik, Andrzej Wincewicz, Sebastian Zięba, Wojciech Baran, Janusz Kopczyński, Mariusz Koda, Stanisław Sulkowski, Stanisław Goźdź   +7 more
doaj   +1 more source