DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial. [PDF]
, 2017 Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature.
Berry, Don +20 more
core +2 more sources
The Role of Nicotinamide in Cancer Chemoprevention and Therapy
Biomolecules, 2020 Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism.
Ilias P. Nikas +2 more
doaj +1 more source
PAR recognition by PARP1 regulates DNA‐dependent activities and independently stimulates catalytic activity of PARP1 [PDF]
The FEBS Journal, 2021 Poly(ADP‐ribosyl)ation is predominantly catalyzed by Poly(ADP‐ribose) polymerase 1 (PARP1) in response to DNA damage, mediating the DNA repair process to maintain genomic integrity. Single‐strand (SSB) and double‐strand (DSB) DNA breaks are bona fide stimulators of PARP1 activity. However, PAR‐mediated PARP1 regulation remains unexplored.
Waghela Deeksha +2 more
openaire +3 more sources
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]
, 2020 Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders.
Beleggia, Filippo +7 more
core +1 more source
PARP1-Erk synergism in proliferating cells [PDF]
Oncotarget, 2018 A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning.
Visochek, Leonid, Cohen-Armon, Malka
openaire +2 more sources
Cancer Research, 2016 Abstract Purpose of study. An attractive strategy to improve antitumor treatments is to inflict cytotoxic DNA damage with chemotherapy, and then impede DNA repair by molecular targeting. TR is a new drug characterized by a peculiar mechanism of action: TR traps DNA repair machinery leading to DNA damage, particularly in BRCA1/2-deficient
Ymera Pignochino +11 more
openaire +6 more sources
Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation
Scientific Reports, 2022 Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death ...
Nidheesh Dadheech +4 more
doaj +1 more source
Biomedicines, 2022 Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair.
Robert J. Lake +2 more
doaj +1 more source
PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines [PDF]
, 2018 PARP inhibitors (PARPi) are used in a wide range of human solid tumours but a limited evidence is reported in rhabdomyosarcoma (RMS), the most frequent childhood soft-tissue sarcoma.
Camero, S +16 more
core +1 more source
Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1
Biophysics and Physicobiology, 2019 PolyADP-ribosylation (PARylation) is a posttranslational modification that is involved in the various cellular functions including DNA repair, genomic stability, and transcriptional regulation.
Kenichi Kouyama +5 more
doaj +1 more source